Mechanism of intramembrane cleavage of alcadeins by γ-secretase (Q34712076)

4 August 2017

Mechanism of intramembrane cleavage of alcadeins by γ-secretase (English)

1 reference

4 August 2017

Yi Piao

1

1 reference

4 August 2017

Ayano Kimura

2

1 reference

4 August 2017

Satomi Urano

3

1 reference

4 August 2017

Yuhki Saito

4

1 reference

4 August 2017

Hidenori Taru

5

1 reference

4 August 2017

Tohru Yamamoto

6

1 reference

4 August 2017

Saori Hata

7

1 reference

4 August 2017

Toshiharu Suzuki

8

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4 August 2017

language of work or name

English

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publication date

26 April 2013

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4 August 2017

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4 August 2017

8

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4 August 2017

4

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4 August 2017

e62431

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Creative Commons Attribution 4.0 International

4 August 2017

start time

26 April 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43.

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Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer's disease subjects

7 July 2018

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The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

7 July 2018

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Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease.

7 July 2018

1 reference

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Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease: evidence for γ-secretase dysfunction

7 July 2018

1 reference

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gamma-secretases: from cell biology to therapeutic strategies

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3637299

Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3637299

Suppression of APP-containing vesicle trafficking and production of beta-amyloid by AID/DHHC-12 protein.

7 July 2018

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Presenilin: running with scissors in the membrane

7 July 2018

1 reference

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Sheddases and intramembrane-cleaving proteases: RIPpers of the membrane. Symposium on regulated intramembrane proteolysis

7 July 2018

1 reference

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The same gamma-secretase accounts for the multiple intramembrane cleavages of APP

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3637299

Secretion of the Notch-1 Abeta-like peptide during Notch signaling

7 July 2018

1 reference

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gamma-Cleavage is dependent on zeta-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain

7 July 2018

1 reference

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Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.

7 July 2018

1 reference

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Intramembrane proteolysis: theme and variations.

7 July 2018

1 reference

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Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3637299

Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3637299

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3637299

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3637299

Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3637299

Translating cell biology into therapeutic advances in Alzheimer's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3637299

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3637299

Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42.

7 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0062431

gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0062431

Potential Link between Amyloid β-Protein 42 and C-terminal Fragment γ 49–99 of β-Amyloid Precursor Protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0062431

A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0062431

Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23658629

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0062431

1 reference

4 August 2017

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1 reference

4 August 2017

1 reference