CTLA-4: new insights into its biological function and use in tumor immunotherapy (Q34711491)

4 August 2017

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title

CTLA-4: new insights into its biological function and use in tumor immunotherapy (English)

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4 August 2017

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3

James P Allison

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Jackson Egen

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Jackson G Egen

series ordinal

1

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author name string

Michael S Kuhns

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2

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PubMed ID

12087419

4 August 2017

language of work or name

English

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publication date

1 July 2002

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4 August 2017

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4 August 2017

3

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4 August 2017

611-618

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4 August 2017

7

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Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy

4 August 2017

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

21 January 2018

The B7-CD28 superfamily

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https://api.crossref.org/works/10.1038%2FNI0702-611

A new member of the immunoglobulin superfamily--CTLA-4

21 January 2018

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https://api.crossref.org/works/10.1038%2FNI0702-611

CTLA-4 is a second receptor for the B cell activation antigen B7

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics

21 January 2018

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https://api.crossref.org/works/10.1038%2FNI0702-611

Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes

21 January 2018

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https://api.crossref.org/works/10.1038%2FNI0702-611

CTLA-4 can function as a negative regulator of T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation

21 January 2018

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https://api.crossref.org/works/10.1038%2FNI0702-611

Superantigen responses and co-stimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo

21 January 2018

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https://api.crossref.org/works/10.1038%2FNI0702-611

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FNI0702-611

The duration of antigenic stimulation determines the fate of naive and effector T cells.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNI0702-611

T cell receptor signaling precedes immunological synapse formation

21 January 2018

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https://api.crossref.org/works/10.1038%2FNI0702-611

Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Augmentation of CTLA-4 expression by wortmannin: involvement of lysosomal sorting properties of CTLA-4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Cytotoxic T lymphocyte-associated molecule-4, a high-avidity receptor for CD80 and CD86, contains an intracellular localization motif in its cytoplasmic tail

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Interaction of the cytoplasmic tail of CTLA-4 (CD152) with a clathrin-associated protein is negatively regulated by tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

The specific direct interaction of helper T cells and antigen-presenting B cells. II. Reorientation of the microtubule organizing center and reorganization of the membrane-associated cytoskeleton inside the bound helper T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

T-cell regulation by CD28 and CTLA-4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Structural mechanisms of costimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

CTLA-4 ligation blocks CD28-dependent T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

CTLA-4 regulates cell cycle progression during a primary immune response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

The role of CTLA-4 in the regulation and initiation of T-cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

B7-1 engagement of cytotoxic T lymphocyte antigen 4 inhibits T cell activation in the absence of CD28.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Absence of CTLA-4 lowers the activation threshold of primed CD8+ TCR-transgenic T cells: lack of correlation with Src homology domain 2-containing protein tyrosine phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates primary and secondary peptide-specific CD4(+) T cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Structural analysis of CTLA-4 function in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Induction of cytotoxic T lymphocyte antigen 4 (CTLA-4) restricts clonal expansion of helper T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Protective immunity to nematode infection is induced by CTLA-4 blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates the size, reactivity, and function of a primed pool of CD4+ T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

T cell affinity maturation by selective expansion during infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

A kinetic basis for T cell receptor repertoire selection during an immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Massive expansion of antigen-specific CD8+ T cells during an acute virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

The composition of a primary T cell response is largely determined by the timing of recruitment of individual T cell clones

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

T cells compete for access to antigen-bearing antigen-presenting cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Selective activation and expansion of high-affinity CD4+ T cells in resistant mice upon infection with Leishmania major.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Cytotoxic T lymphocyte antigen-4 (CTLA-4) limits the expansion of encephalitogenic T cells in experimental autoimmune encephalomyelitis (EAE)-resistant BALB/c mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Antagonistic roles for CTLA-4 and the mammalian target of rapamycin in the regulation of clonal anergy: enhanced cell cycle progression promotes recall antigen responsiveness.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Enhancement of antitumor immunity by CTLA-4 blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

In vivo blockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

CTLA-4 blockade synergizes with tumor-derived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accomp

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: comparison of prophylaxis and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

The central role of CD4(+) T cells in the antitumor immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

CTLA-4: a negative regulator of autoimmune disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Specific blockade of CTLA-4/B7 interactions results in exacerbated clinical and histologic disease in an actively-induced model of experimental allergic encephalomyelitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

T cell infiltration of the prostate induced by androgen withdrawal in patients with prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Normal pathogen-specific immune responses mounted by CTLA-4-deficient T cells: a paradigm reconsidered

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

inferred from DOI database lookup

7 January 2021

based on heuristic

CTLA-4 blockade reverses CD8+ T cell tolerance to tumor by a CD4+ T cell- and IL-2-dependent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FNI0702-611

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NI0702-611

1 reference

4 August 2017

1 reference

PubMed ID

12087419