Silencing of ANGPTL 3 (angiopoietin-like protein 3) in human hepatocytes results in decreased expression of gluconeogenic genes and reduced triacylglycerol-rich VLDL secretion upon insulin stimulation (Q34706796)

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English	Silencing of ANGPTL 3 (angiopoietin-like protein 3) in human hepatocytes results in decreased expression of gluconeogenic genes and reduced triacylglycerol-rich VLDL secretion upon insulin stimulation	scientific article

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scholarly article

1 reference

Europe PubMed Central

4 August 2017

Silencing of ANGPTL 3 (angiopoietin-like protein 3) in human hepatocytes results in decreased expression of gluconeogenic genes and reduced triacylglycerol-rich VLDL secretion upon insulin stimulation (English)

1 reference

Europe PubMed Central

4 August 2017

0 references

Matti Jauhiainen

6

object named as

Matti Jauhiainen

1 reference

Europe PubMed Central

4 August 2017

author name string

Anna Tikka

1

1 reference

Europe PubMed Central

4 August 2017

Jarkko Soronen

2

1 reference

Europe PubMed Central

4 August 2017

Pirkka-Pekka Laurila

3

1 reference

Europe PubMed Central

4 August 2017

Jari Metso

4

1 reference

Europe PubMed Central

4 August 2017

Christian Ehnholm

5

1 reference

Europe PubMed Central

4 August 2017

publication date

12 December 2014

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Europe PubMed Central

4 August 2017

Bioscience Reports

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Europe PubMed Central

4 August 2017

34

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Europe PubMed Central

4 August 2017

e00160

1 reference

Europe PubMed Central

4 August 2017

6

1 reference

Europe PubMed Central

4 August 2017

copyright license

Creative Commons Attribution 3.0 Unported

25 July 2019

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April 2022 Public Data File from Crossref

copyright status

0 references

Clinical characteristics and plasma lipids in subjects with familial combined hypolipidemia: a pooled analysis

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7 July 2018

Mutations in the ANGPTL3 gene and familial combined hypolipidemia: a clinical and biochemical characterization

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Regulation of hepatic glucose uptake and storage in vivo

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Comparative gene expression profiles induced by PPARγ and PPARα/γ agonists in rat hepatocytes

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7 July 2018

Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia

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7 July 2018

MAPK phosphatase-3 promotes hepatic gluconeogenesis through dephosphorylation of forkhead box O1 in mice

1 reference

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Biological, clinical and population relevance of 95 loci for blood lipids

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Angiopoietin-like protein 3 inhibits lipoprotein lipase activity through enhancing its cleavage by proprotein convertases

1 reference

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Quantitation of serum angiopoietin-like proteins 3 and 4 in a Finnish population sample

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Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans.

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The angiopoietin-like proteins ANGPTL3 and ANGPTL4 inhibit lipoprotein lipase activity through distinct mechanisms

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Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

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Newly identified loci that influence lipid concentrations and risk of coronary artery disease

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PGC-1 coactivators: inducible regulators of energy metabolism in health and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266921

7 July 2018

Reduction of hepatic glucose production as a therapeutic target in the treatment of diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266921

7 July 2018

Leptin and insulin down-regulate angiopoietin-like protein 3, a plasma triglyceride-increasing factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266921

7 July 2018

Role of peroxisome proliferator-activated receptor-gamma in the glucose-sensing apparatus of liver and beta-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266921

7 July 2018

Protein region important for regulation of lipid metabolism in angiopoietin-like 3 (ANGPTL3): ANGPTL3 is cleaved and activated in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266921

7 July 2018

A decreased expression of angiopoietin-like 3 is protective against atherosclerosis in apoE-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266921

7 July 2018

Angiopoietin-like protein 3, a hepatic secretory factor, activates lipolysis in adipocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266921

7 July 2018

ANGPTL3 decreases very low density lipoprotein triglyceride clearance by inhibition of lipoprotein lipase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266921

7 July 2018

Angptl3 regulates lipid metabolism in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266921

7 July 2018

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266921

7 July 2018

Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266921

7 July 2018

Identification of a mammalian angiopoietin-related protein expressed specifically in liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266921

7 July 2018

Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266921

7 July 2018

Structure, function, and regulation of the mammalian facilitative glucose transporter gene family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266921

7 July 2018

Evidence for a transient inhibitory effect of insulin on GLUT2 expression in the liver: studies in vivo and in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266921

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Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering

1 reference

https://api.crossref.org/works/10.1042%2FBSR20140115

21 January 2018

Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL).

1 reference

https://api.crossref.org/works/10.1042%2FBSR20140115

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Angptl3 deficiency is associated with increased insulin sensitivity, lipoprotein lipase activity, and decreased serum free fatty acids

1 reference

https://api.crossref.org/works/10.1042%2FBSR20140115

21 January 2018

Effects of insulin resistance and type 2 diabetes on lipoprotein subclass particle size and concentration determined by nuclear magnetic resonance

1 reference

https://api.crossref.org/works/10.1042%2FBSR20140115

21 January 2018

PI3-kinase activity modulates apo B available for hepatic VLDL production in apobec-1-/- mice.

1 reference

https://api.crossref.org/works/10.1042%2FBSR20140115

21 January 2018

Ameliorated hepatic insulin resistance is associated with normalization of microsomal triglyceride transfer protein expression and reduction in very low density lipoprotein assembly and secretion in the fructose-fed hamster

1 reference

https://api.crossref.org/works/10.1042%2FBSR20140115

21 January 2018

Effects of rosiglitazone and pioglitazone on lipoprotein metabolism in patients with Type 2 diabetes and normal lipids.

1 reference

https://api.crossref.org/works/10.1042%2FBSR20140115

21 January 2018

ANGPTL3 is increased in both insulin-deficient and -resistant diabetic states.

1 reference

https://api.crossref.org/works/10.1042%2FBSR20140115

21 January 2018

PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3.

1 reference

https://api.crossref.org/works/10.1042%2FBSR20140115

21 January 2018

Defective regulation of triglyceride metabolism by insulin in the liver in NIDDM

1 reference

https://pubmed.ncbi.nlm.nih.gov/25495645

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute suppression of VLDL1 secretion rate by insulin is associated with hepatic fat content and insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/25495645

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BSR20140115

1 reference

Europe PubMed Central

4 August 2017

1 reference

Europe PubMed Central

4 August 2017

1 reference

Europe PubMed Central

4 August 2017

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