Safety evaluation and pharmacokinetics of a novel human tumor necrosis factor-alpha exhibited a higher antitumor activity and a lower systemic toxicity (Q34701747)

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English	Safety evaluation and pharmacokinetics of a novel human tumor necrosis factor-alpha exhibited a higher antitumor activity and a lower systemic toxicity	scientific article

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scholarly article

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18 January 2020

Safety evaluation and pharmacokinetics of a novel human tumor necrosis factor-alpha exhibited a higher antitumor activity and a lower systemic toxicity (English)

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18 January 2020

pharmacokinetics

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based on heuristic

inferred from title

3

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18 January 2020

4

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18 January 2020

author name string

Meng Li

1

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18 January 2020

Xin Qin

2

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18 January 2020

Cun Zhang

5

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18 January 2020

Zhen Yan

6

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18 January 2020

Wei Han

7

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18 January 2020

Chris Komarck

8

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18 January 2020

Thomas D Wang

9

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18 January 2020

Yingqi Zhang

10

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18 January 2020

publication date

1 March 2010

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18 January 2020

Anti-Cancer Drugs

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18 January 2020

21

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18 January 2020

243-251

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18 January 2020

3

1 reference

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18 January 2020

TNF-based isolated hepatic perfusion

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7 July 2018

Integrin-targeted imaging and therapy with RGD4C-TNF fusion protein

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7 July 2018

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

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7 July 2018

A mutated human tumor necrosis factor-alpha improves the therapeutic index in vitro and in vivo

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7 July 2018

Target-selective activation of a TNF prodrug by urokinase-type plasminogen activator (uPA) mediated proteolytic processing at the cell surface

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7 July 2018

Expression, purification, and characterization of a neovasculature targeted rmhTNF-alpha in Escherichia coli

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7 July 2018

A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway

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7 July 2018

Functional identification of the alveolar edema reabsorption activity of murine tumor necrosis factor-alpha

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7 July 2018

TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2

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7 July 2018

The TNF and TNF receptor superfamilies: integrating mammalian biology

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7 July 2018

Human tumor necrosis factor-alpha mutant RGD-V29 (F4614) shows potent antitumor activity and reduced toxicity against human tumor xenografted nude mice

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7 July 2018

Tumor necrosis factor receptor and Fas signaling mechanisms.

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7 July 2018

A novel tumor necrosis factor-alpha mutant with significantly enhanced cytotoxicity and receptor binding affinity.

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7 July 2018

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

1 reference

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7 July 2018

A novel domain within the 55 kd TNF receptor signals cell death

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7 July 2018

Human TNF mutants with selective activity on the p55 receptor.

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7 July 2018

A human tumor necrosis factor (TNF) alpha mutant that binds exclusively to the p55 TNF receptor produces toxicity in the baboon

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7 July 2018

Conformation and ion channel activity of lymphotoxin at neutral and low pH.

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7 July 2018

Dissociation of TNF-alpha cytotoxic and proinflammatory activities by p55 receptor- and p75 receptor-selective TNF-alpha mutants.

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7 July 2018

Recombinant human tumor necrosis factor-alpha: effects on proliferation of normal and transformed cells in vitro.

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7 July 2018

Phase I study of recombinant tumor necrosis factor in cancer patients.

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7 July 2018

Phase I trial of recombinant human gamma-interferon and recombinant human tumor necrosis factor in patients with advanced gastrointestinal cancer

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7 July 2018

Comparison of the intoxication pathways of tumor necrosis factor and diphtheria toxin

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7 July 2018

NG-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide

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7 July 2018

The two different receptors for tumor necrosis factor mediate distinct cellular responses

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7 July 2018

Tumor necrosis factor. Characterization at the molecular, cellular and in vivo level

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7 July 2018

A novel recombinant tumor necrosis factor-alpha mutant with increased anti-tumor activity and lower toxicity

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7 July 2018

The p70 tumor necrosis factor receptor mediates cytotoxicity

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7 July 2018

An endotoxin-induced serum factor that causes necrosis of tumors

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7 July 2018

Induction of apoptosis by TNF receptor 2 in a T-cell hybridoma is FADD dependent and blocked by caspase-8 inhibitors

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26 October 2018

Isolated limb perfusion with tumor necrosis factor and melphalan for non-resectable soft tissue sarcomas: long-term results on efficacy and limb salvage in a selected group of patients

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improvement of cytotoxicity of tumor necrosis factor (TNF) by increase in basicity of its N-terminal region

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of differentiation of human monoblastic and myeloblastic leukemia cell lines by TNF muteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/20166241

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Both TNF receptors are required for direct TNF-mediated cytotoxicity in microvascular endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20166241

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the anti-tumor efficacy of systemically administered recombinant tumor necrosis factor against several murine tumors in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/20166241

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that tumor necrosis factor triggers apoptosis in human endothelial cells by interleukin-1-converting enzyme-like protease-dependent and -independent pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/20166241

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biological effects of recombinant human tumor necrosis factor and its novel muteins on tumor and normal cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/20166241

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects on leukocytes after injection of tumor necrosis factor into healthy humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/20166241

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cures and partial regression of murine and human tumors by recombinant human tumor necrosis factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/20166241

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1097/CAD.0B013E328333D5CE

1 reference

Europe PubMed Central

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18 January 2020

1 reference

Europe PubMed Central

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18 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20166241%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

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