Modulation of PC1/3 activity by self-interaction and substrate binding (Q34696850)

4 August 2017

title

Modulation of PC1/3 activity by self-interaction and substrate binding (English)

1 reference

4 August 2017

Akina Hoshino

1

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4 August 2017

Dorota Kowalska

2

1 reference

4 August 2017

François Jean

3

1 reference

4 August 2017

Claude Lazure

4

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4 August 2017

Iris Lindberg

5

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4 August 2017

language of work or name

English

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publication date

8 February 2011

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4 August 2017

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4 August 2017

volume

152

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4 August 2017

issue

4

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4 August 2017

page(s)

1402-1411

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Association of obesity risk SNPs in PCSK1 with insulin sensitivity and proinsulin conversion

4 August 2017

cites work

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7 July 2018

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The C-terminal region of the proprotein convertase 1/3 (PC1/3) exerts a bimodal regulation of the enzyme activity in vitro

7 July 2018

1 reference

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Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency

7 July 2018

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Functional characterization of ProSAAS: similarities and differences with 7B2.

7 July 2018

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Inhibitory specificity and potency of proSAAS-derived peptides toward proprotein convertase 1.

7 July 2018

1 reference

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A predicted alpha -helix mediates targeting of the proprotein convertase PC1 to the regulated secretory pathway

7 July 2018

1 reference

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The SAAS granin exhibits structural and functional homology to 7B2 and contains a highly potent hexapeptide inhibitor of PC1.

7 July 2018

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Identification and characterization of proSAAS, a granin-like neuroendocrine peptide precursor that inhibits prohormone processing

7 July 2018

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The cell biology of the prohormone convertases PC1 and PC2.

7 July 2018

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Molecular characterization, enzymatic analysis, and purification of murine proprotein convertase-1/3 (PC1/PC3) secreted from recombinant baculovirus-infected insect cells

7 July 2018

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Identification of inhibitors of prohormone convertases 1 and 2 using a peptide combinatorial library

7 July 2018

1 reference

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The proprotein convertases

7 July 2018

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Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

7 July 2018

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Activation of the furin endoprotease is a multiple-step process: requirements for acidification and internal propeptide cleavage

7 July 2018

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7 July 2018

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Purification and characterization of the candidate prohormone-processing enzyme SPC3 produced in a mouse L cell line

7 July 2018

1 reference

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Endoproteolytic processing of proopiomelanocortin and prohormone convertases 1 and 2 in neuroendocrine cells overexpressing prohormone convertases 1 or 2.

7 July 2018

1 reference

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The radiation inactivation method as a tool to study structure-function relationships in proteins

7 July 2018

1 reference

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Effects of ionizing radiations on proteins. Evidence of non-random fragmentations and a caution in the use of the method for determination of molecular mass

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060626

Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.

7 July 2018

1 reference

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Mammalian Neural and Endocrine Pro-Protein and Pro-Hormone Convertases Belonging to the Subtilisin Family of Serine Proteinases

7 July 2018

1 reference

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Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060626

Biosynthesis of the prohormone convertase mPC1 in AtT-20 cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060626

Common PCSK1 haplotypes are associated with obesity in the Chinese population

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060626

Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3.

26 October 2018

1 reference

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Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060626

Enzymatic activity of soluble and membrane tethered peptide pro-hormone convertase 1.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060626

Tissue distribution and processing of proSAAS by proprotein convertases

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060626

Release of the prohormone convertase PC1 from AtT-20 cells

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060626

Enzymic characterization of murine and human prohormone convertase-1 (mPC1 and hPC1) expressed in mammalian GH4C1 cells

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060626

Enzymatic properties of carboxyl-terminally truncated prohormone convertase 1 (PC1/SPC3) and evidence for autocatalytic conversion.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060626

Common nonsynonymous variants in PCSK1 confer risk of obesity

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060626

The C-terminal Region of proSAAS Is a Potent Inhibitor of Prohormone Convertase 1

9 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060626

9 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060626

Purification and characterization of the prohormone convertase PC1(PC3)

9 December 2018

1 reference

12 December 2020

Identification of the region within the neuroendocrine polypeptide 7B2 responsible for the inhibition of prohormone convertase PC2

1 reference

12 December 2020

Mutational analysis of PC1 (SPC3) in PC12 cells. 66-kDa PC1 is fully functional.

1 reference

12 December 2020

7B2 prevents unfolding and aggregation of prohormone convertase 2

1 reference

12 December 2020

Identifiers

DOI

10.1210/EN.2010-1170

1 reference

4 August 2017

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4 August 2017

1 reference