Structural basis of effector regulation and signal termination in heterotrimeric Galpha proteins (Q34686939)

3 August 2017

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title

Structural basis of effector regulation and signal termination in heterotrimeric Galpha proteins (English)

1 reference

3 August 2017

Stephen R Sprang

1

1 reference

PubMed ID

17854654

3 August 2017

Zhe Chen

series ordinal

2

1 reference

PubMed ID

17854654

3 August 2017

Xinlin Du

series ordinal

3

1 reference

3 August 2017

1 January 2007

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Advances in Protein Chemistry

3 August 2017

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3 August 2017

74

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3 August 2017

1-65

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RGS proteins have a signalling complex: interactions between RGS proteins and GPCRs, effectors, and auxiliary proteins

3 August 2017

1 reference

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7 January 2021

Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain

1 reference

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7 January 2021

RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryos

1 reference

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7 January 2021

Ras catalyzes GTP hydrolysis by shifting negative charges from gamma- to beta-phosphate as revealed by time-resolved FTIR difference spectroscopy

1 reference

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7 January 2021

Monitoring the GAP catalyzed H-Ras GTPase reaction at atomic resolution in real time

1 reference

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7 January 2021

Amino-terminal myristoylation induces cooperative calcium binding to recoverin

1 reference

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7 January 2021

A GTPase-accelerating factor for transducin, distinct from its effector cGMP phosphodiesterase, in rod outer segment membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

GTP hydrolysis by purified alpha-subunit of transducin and its complex with the cyclic GMP phosphodiesterase inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Mapping regions of Gαqinteracting with PLCβ1 using multiple overlapping synthetic peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Regulation of deactivation of photoreceptor G protein by its target enzyme and cGMP

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Lifetime regulation of G protein-effector complex: emerging importance of RGS proteins

1 reference

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7 January 2021

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7 January 2021

A perspective on enzyme catalysis.

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7 January 2021

Structure of the GDP-Pi complex of Gly203-->Ala gialpha1: a mimic of the ternary product complex of galpha-catalyzed GTP hydrolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Identification of effector-activating residues of Gs alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Mammalian RGS proteins: barbarians at the gate

1 reference

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7 January 2021

The GTPase-activating protein RGS4 stabilizes the transition state for nucleotide hydrolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits

1 reference

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7 January 2021

Phospholipase C-beta 1 is a GTPase-activating protein for Gq/11, its physiologic regulator

1 reference

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7 January 2021

Regulation of phospholipase C-beta1 by Gq and m1 muscarinic cholinergic receptor. Steady-state balance of receptor-mediated activation and GTPase-activating protein-promoted deactivation

1 reference

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7 January 2021

Leukemia-associated Rho guanine nucleotide exchange factor promotes G alpha q-coupled activation of RhoA.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

The GTPase superfamily: conserved structure and molecular mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Functional regions of the inhibitory subunit of retinal rod cGMP phosphodiesterase identified by site-specific mutagenesis and fluorescence spectroscopy

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Gi protein activation in intact cells involves subunit rearrangement rather than dissociation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Lipid modifications of G proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Mechanism of adenylate cyclase activation through the beta-adrenergic receptor: catecholamine-induced displacement of bound GDP by GTP

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Time-resolved FTIR studies of the GTPase reaction of H-ras p21 reveal a key role for the beta-phosphate.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

The Dbl family of oncogenes

1 reference

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7 January 2021

Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast

1 reference

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7 January 2021

The vertebrate phototransduction cascade: amplification and termination mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Slowed recovery of rod photoresponse in mice lacking the GTPase accelerating protein RGS9-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Structure of the p115RhoGEF rgRGS domain-Galpha13/i1 chimera complex suggests convergent evolution of a GTPase activator

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Homo- and hetero-oligomerization of PDZ-RhoGEF, LARG and p115RhoGEF by their C-terminal region regulates their in vivo Rho GEF activity and transforming potential

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Probing the structure and mechanism of Ras protein with an expanded genetic code

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Crystal structures of the G protein Gi alpha 1 complexed with GDP and Mg2+: a crystallographic titration experiment

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Structure of Gialpha1.GppNHp, autoinhibition in a galpha protein-substrate complex

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Regulation and organization of adenylyl cyclases and cAMP.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

The GTPase-activating protein Rap1GAP uses a catalytic asparagine

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Characterization of the GRK2 binding site of Galphaq

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

How do G proteins directly control neuronal Ca2+ channel function?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Purification and characterization of a soluble form of mammalian adenylyl cyclase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Interactions of forskolin and ATP with the cytosolic domains of mammalian adenylyl cyclase.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Identification of a Gialpha binding site on type V adenylyl cyclase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

The interactions of adenylate cyclases with P-site inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Mechanism of Galpha i-mediated inhibition of type V adenylyl cyclase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Selective uncoupling of RGS action by a single point mutation in the G protein alpha-subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Determination of the contact energies between a regulator of G protein signaling and G protein subunits and phospholipase C beta 1

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Stable association between G alpha(q) and phospholipase C beta 1 in living cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

The mechanism of GTP hydrolysis by Ras probed by Fourier transform infrared spectroscopy

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Kinetic isotope effects in Ras-catalyzed GTP hydrolysis: evidence for a loose transition state

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

G Protein activation without subunit dissociation depends on a G{alpha}(i)-specific region.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

G proteins: transducers of receptor-generated signals

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

How does GAP catalyze the GTPase reaction of Ras? A computer simulation study

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

The significance of the free energy of hydrolysis of GTP for signal-transducing and regulatory GTPases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Functional consequences of G alpha 13 mutations that disrupt interaction with p115RhoGEF

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

QM/MM modeling the Ras-GAP catalyzed hydrolysis of guanosine triphosphate.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Identification of common and distinct residues involved in the interaction of alphai2 and alphas with adenylyl cyclase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Dimerization of mammalian adenylate cyclases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Rhodopsin-stimulated activation-deactivation cycle of transducin: kinetics of the intrinsic fluorescence response of the alpha subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

The many faces of G protein signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Regulation and role of adenylyl cyclase isoforms

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

RGS9, a GTPase accelerator for phototransduction

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

RGS-7 completes a receptor-independent heterotrimeric G protein cycle to asymmetrically regulate mitotic spindle positioning in C. elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

RGS2/G0S8 is a selective inhibitor of Gqalpha function

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

G protein selectivity is a determinant of RGS2 function.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Cellular regulation of RGS proteins: modulators and integrators of G protein signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

R9AP, a membrane anchor for the photoreceptor GTPase accelerating protein, RGS9-1

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Cell signalling diversity of the Gqalpha family of heterotrimeric G proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Structure, mechanism, and regulation of mammalian adenylyl cyclase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Mutations in the carboxyl-terminal domain of phospholipase C-beta 1 delineate the dimer interface and a potential Galphaq interaction site

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Dynamic Regulation of RGS2 Suggests a Novel Mechanism in G-Protein Signaling and Neuronal Plasticity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Molecular surface recognition: determination of geometric fit between proteins and their ligands by correlation techniques

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

The role of carboxyl-terminal basic amino acids in Gqalpha-dependent activation, particulate association, and nuclear localization of phospholipase C-beta1.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

The crystal structure of elongation factor EF-Tu from Thermus aquaticus in the GTP conformation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Theoretical IR spectroscopy based on QM/MM calculations provides changes in charge distribution, bond lengths, and bond angles of the GTP ligand induced by the Ras-protein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

A new family of G-protein regulators - the RGS proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

A new approach to producing functional G alpha subunits yields the activated and deactivated structures of G alpha(12/13) proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

The role of receptor kinases and arrestins in G protein-coupled receptor regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

The 2.0 A crystal structure of a heterotrimeric G protein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

A point mutation in Galphao and Galphai1 blocks interaction with regulator of G protein signaling proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Rapid kinetics of regulator of G-protein signaling (RGS)-mediated Galphai and Galphao deactivation. Galpha specificity of RGS4 AND RGS7

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

On the mechanism of guanosine triphosphate hydrolysis in ras p21 proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Kinetic analysis by fluorescence of the interaction between Ras and the catalytic domain of the guanine nucleotide exchange factor Cdc25Mm

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

The class III adenylyl cyclases: multi-purpose signalling modules

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Active sites of the cyclic GMP phosphodiesterase gamma-subunit of retinal rod outer segments

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

The role of G beta gamma and domain interfaces in the activation of G protein-coupled receptor kinase 2.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Ras-catalyzed hydrolysis of GTP: a new perspective from model studies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

The GTPase activating factor for transducin in rod photoreceptors is the complex between RGS9 and type 5 G protein beta subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Separate GTP binding and GTPase activating domains of a G alpha subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Modulation of transducin GTPase activity by chimeric RGS16 and RGS9 regulators of G protein signaling and the effector molecule

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Selective uncoupling of G alpha 12 from Rho-mediated signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

A mutation that prevents GTP-dependent activation of the alpha chain of Gs.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Physiological regulation of G protein-linked signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Structural basis for the inhibition of mammalian membrane adenylyl cyclase by 2 '(3')-O-(N-Methylanthraniloyl)-guanosine 5 '-triphosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Rapid GTP binding and hydrolysis by G(q) promoted by receptor and GTPase-activating proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Critical role of lysine 204 in switch I region of Galpha13 for regulation of p115RhoGEF and leukemia-associated RhoGEF.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

A single mutation Asp229 --> Ser confers upon Gs alpha the ability to interact with regulators of G protein signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Substitution of transducin ser202 by asp abolishes G-protein/RGS interaction

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

A point mutation uncouples transducin-alpha from the photoreceptor RGS and effector proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Identification of effector residues on photoreceptor G protein, transducin.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Mutational analysis of the Asn residue essential for RGS protein binding to G-proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Hydrolysis of GTP by p21NRAS, the NRAS protooncogene product, is accompanied by a conformational change in the wild-type protein: use of a single fluorescent probe at the catalytic site

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Activation of transducin guanosine triphosphatase by two proteins of the RGS family

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Interaction between the retinal cyclic GMP phosphodiesterase inhibitor and transducin. Kinetics and affinity studies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Crystallographic evidence for substrate-assisted GTP hydrolysis by a small GTP binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Carboxyl-terminal fragments of phospholipase C-beta1 with intrinsic Gq GTPase-activating protein (GAP) activity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

G(alpha)(i) controls the gating of the G protein-activated K(+) channel, GIRK.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

The mechanism of Ras GTPase activation by neurofibromin.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

G protein-coupled receptor kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Modulation of the affinity and selectivity of RGS protein interaction with G alpha subunits by a conserved asparagine/serine residue

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

X-ray crystal structures of transforming p21 ras mutants suggest a transition-state stabilization mechanism for GTP hydrolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Structural and biochemical characterization of the GTPgammaS-, GDP.Pi-, and GDP-bound forms of a GTPase-deficient Gly42 --> Val mutant of Gialpha1

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Regulation of phosphoinositide-specific phospholipase C

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Structure at 1.65 A of RhoA and its GTPase-activating protein in complex with a transition-state analogue

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Larger than Dbl: new structural insights into RhoA activation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Gating of GIRK channels: details of an intricate, membrane-delimited signaling complex

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Selective regulation of Gq signaling by G protein-coupled receptor kinase 2: direct interaction of kinase N terminus with activated galphaq.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

The pre-hydrolysis state of p21(ras) in complex with GTP: new insights into the role of water molecules in the GTP hydrolysis reaction of ras-like proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Transduction mechanisms in vertebrate olfactory receptor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Why have mutagenesis studies not located the general base in ras p21.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Linear free energy relationships in the intrinsic and GTPase activating protein-stimulated guanosine 5'-triphosphate hydrolysis of p21ras.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Why does the Ras switch "break" by oncogenic mutations?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

G protein regulation of adenylate cyclase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase D

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Structures, mechanism, regulation and evolution of class III nucleotidyl cyclases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Mapping of effector binding sites of transducin alpha-subunit using G alpha t/G alpha i1 chimeras

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

The alpha-helical domain of Galphat determines specific interaction with regulator of G protein signaling 9

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

An effector site that stimulates G-protein GTPase in photoreceptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

A regulator of G protein signaling interaction surface linked to effector specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Prediction and confirmation of a site critical for effector regulation of RGS domain activity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

G protein mechanisms: insights from structural analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Plasma membrane localization is required for RGS4 function in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

G protein-coupled receptor Kinase 2/G alpha q/11 interaction. A novel surface on a regulator of G protein signaling homology domain for binding G alpha subunits.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Isoforms of mammalian adenylyl cyclase: multiplicities of signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Complexity and diversity of mammalian adenylyl cyclases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Interaction of Gsalpha with the cytosolic domains of mammalian adenylyl cyclase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Crystal structure of the adenylyl cyclase activator Gsalpha

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Sequestration of the membrane-targeting myristoyl group of recoverin in the calcium-free state

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Construction of a soluble adenylyl cyclase activated by Gs alpha and forskolin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Truncation and alanine-scanning mutants of type I adenylyl cyclase.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Inhibition of adenylyl cyclase by Gi alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Activation of the β1 isozyme of phospholipase C by α subunits of the Gq class of G proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Yeast and mammalian ras proteins have conserved biochemical properties

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

The structure, catalytic mechanism and regulation of adenylyl cyclase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Two-metal-Ion catalysis in adenylyl cyclase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Molecular basis for P-site inhibition of adenylyl cyclase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Uncoupling conformational change from GTP hydrolysis in a heterotrimeric G protein alpha-subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Molecular mechanism of GTP hydrolysis by bovine transducin: pre-steady-state kinetic analyses

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Quantum chemical modeling of the GTP hydrolysis by the RAS-GAP protein complex

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Inhibition of brain Gz GAP and other RGS proteins by palmitoylation of G protein alpha subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Identification of determinants in the alpha-subunit of Gq required for phospholipase C activation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

The guanine nucleotide-binding switch in three dimensions

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Structural basis of activity and subunit recognition in G protein heterotrimers

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Selective interaction of the C2 domains of phospholipase C-beta1 and -beta2 with activated Galphaq subunits: an alternative function for C2-signaling modules

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

RGS family members: GTPase-activating proteins for heterotrimeric G-protein alpha-subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Lipid modifications of trimeric G proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Identification of potential mechanisms for regulation of p115 RhoGEF through analysis of endogenous and mutant forms of the exchange factor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Mechanisms for reversible regulation between G13 and Rho exchange factors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

New roles for Galpha and RGS proteins: communication continues despite pulling sisters apart

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Return of the GDI: the GoLoco motif in cell division.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Phosphoryl transfer in Ras proteins, conclusive or elusive?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Regions on adenylyl cyclase that are necessary for inhibition of activity by beta gamma and G(ialpha) subunits of heterotrimeric G proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

RGS Proteins Determine Signaling Specificity of Gq-coupled Receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Three discrete regions of mammalian adenylyl cyclase form a site for Gsalpha activation.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Predicting conformational switches in proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Rapid irreversible G protein alpha subunit misfolding due to intramolecular kinetic bottleneck that precedes Mg2+ "lock" after GTP/GDP exchange

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

The N-terminal domain of RGS4 confers receptor-selective inhibition of G protein signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

G-protein signaling: fine-tuning signaling kinetics

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Structure of the adenylyl cyclase catalytic core

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Divergence of RGS proteins: evidence for the existence of six mammalian RGS subfamilies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformations

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

A spatial focusing model for G protein signals. Regulator of G protein signaling (RGS) protien-mediated kinetic scaffolding.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3233%2807%2974001-9

7 January 2021

10.1016/S0065-3233(07)74001-9

Identifiers

DOI

1 reference

3 August 2017

1 reference

PubMed ID

17854654