Combined inhibition of Notch signaling and Bcl-2/Bcl-xL results in synergistic antimyeloma effect (Q34683589)

3 August 2017

title

Combined inhibition of Notch signaling and Bcl-2/Bcl-xL results in synergistic antimyeloma effect (English)

1 reference

3 August 2017

Ming Li

1

1 reference

3 August 2017

Feng Chen

2

1 reference

3 August 2017

Nicholas Clifton

3

1 reference

3 August 2017

Daniel M Sullivan

4

1 reference

3 August 2017

William S Dalton

5

1 reference

3 August 2017

Dmitry I Gabrilovich

6

1 reference

3 August 2017

Yulia Nefedova

7

1 reference

3 August 2017

publication date

1 December 2010

1 reference

Molecular Cancer Therapeutics

3 August 2017

published in

1 reference

3 August 2017

volume

9

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3 August 2017

issue

12

1 reference

3 August 2017

page(s)

3200-3209

1 reference

Induction of Noxa sensitizes human colorectal cancer cells expressing Mcl-1 to the small-molecule Bcl-2/Bcl-xL inhibitor, ABT-737.

3 August 2017

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7 July 2018

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7 July 2018

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7 July 2018

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A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation

7 July 2018

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Inhibition of Notch signaling induces apoptosis of myeloma cells and enhances sensitivity to chemotherapy

7 July 2018

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Targeting multiple arms of the apoptotic regulatory machinery

7 July 2018

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7 July 2018

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7 July 2018

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The Bcl-2 family protein inhibitor, ABT-737, has substantial antimyeloma activity and shows synergistic effect with dexamethasone and melphalan.

7 July 2018

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Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation

7 July 2018

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'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737.

7 July 2018

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

7 July 2018

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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

7 July 2018

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Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

7 July 2018

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Activation of dendritic cells via inhibition of Jak2/STAT3 signaling

7 July 2018

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Killing cancer cells by flipping the Bcl-2/Bax switch.

7 July 2018

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Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival.

7 July 2018

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

7 July 2018

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7 July 2018

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Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

7 July 2018

1 reference

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Farnesyltransferase inhibitor BMS-214662 induces apoptosis in myeloma cells through PUMA up-regulation, Bax and Bak activation, and Mcl-1 elimination.

7 July 2018

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

7 July 2018

1 reference

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Mcl-1 regulation and its role in multiple myeloma

7 July 2018

1 reference

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Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058809

Involvement of Notch-1 signaling in bone marrow stroma-mediated de novo drug resistance of myeloma and other malignant lymphoid cell lines

7 July 2018

1 reference

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Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agents

7 July 2018

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

7 July 2018

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An invitation to T and more: notch signaling in lymphopoiesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058809

Notch signaling: cell fate control and signal integration in development

7 July 2018

1 reference

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Heterodimerization-independent functions of cell death regulatory proteins Bax and Bcl-2 in yeast and mammalian cells

7 July 2018

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Expression of the bcl-2 gene in human multiple myeloma cell lines and normal plasma cells

7 July 2018

1 reference

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Notch versus the proteasome: what is the target of gamma-secretase inhibitor-I?

7 July 2018

1 reference

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A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma.

26 October 2018

1 reference

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Differential expression of Bcl-2 in human plasma cell disorders according to proliferation status and malignancy.

26 October 2018

1 reference

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Bcl-2 protein expression is not related to short survival in multiple myeloma

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21159606

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/1535-7163.MCT-10-0372

1 reference

3 August 2017

1 reference

3 August 2017

1 reference