UCN-01 induces S and G2/M cell cycle arrest through the p53/p21(waf1) or CHK2/CDC25C pathways and can suppress invasion in human hepatoma cell lines (Q34640744)

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English	UCN-01 induces S and G2/M cell cycle arrest through the p53/p21(waf1) or CHK2/CDC25C pathways and can suppress invasion in human hepatoma cell lines	scientific article

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scholarly article

1 reference

Europe PubMed Central

3 August 2017

UCN-01 induces S and G2/M cell cycle arrest through the p53/p21(waf1) or CHK2/CDC25C pathways and can suppress invasion in human hepatoma cell lines (English)

1 reference

Europe PubMed Central

3 August 2017

hepatocellular carcinoma

1 reference

based on heuristic

inferred from title

author name string

Guoyi Wu

1

1 reference

Europe PubMed Central

3 August 2017

Nan Lin

2

1 reference

Europe PubMed Central

3 August 2017

Linan Xu

3

1 reference

Europe PubMed Central

3 August 2017

Bo Liu

4

1 reference

Europe PubMed Central

3 August 2017

Mark A Feitelson

5

1 reference

Europe PubMed Central

3 August 2017

language of work or name

0 references

publication date

28 March 2013

1 reference

Europe PubMed Central

3 August 2017

1 reference

Europe PubMed Central

3 August 2017

13

1 reference

Europe PubMed Central

3 August 2017

167

1 reference

Europe PubMed Central

3 August 2017

https://scigraph.springernature.com/pub.10.1186/1471-2407-13-167

0 references

A phase II study of cell cycle inhibitor UCN-01 in patients with metastatic melanoma: a California Cancer Consortium trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618254

7 July 2018

A Phase 1 study of UCN-01 in combination with irinotecan in patients with resistant solid tumor malignancies

1 reference

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7 July 2018

The release of microparticles by Jurkat leukemia T cells treated with staurosporine and related kinase inhibitors to induce apoptosis

1 reference

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7 July 2018

A role for Chk2 in DNA damage induced mitotic delays in human colorectal cancer cells

1 reference

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7 July 2018

A phase I trial of UCN-01 and prednisone in patients with refractory solid tumors and lymphomas

1 reference

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7 July 2018

The prolyl cis/trans isomerase cyclophilin 18 interacts with the tumor suppressor p53 and modifies its functions in cell cycle regulation and apoptosis.

1 reference

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URG11 promotes gastric cancer growth and invasion by activation of beta-catenin signalling pathway

1 reference

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7 July 2018

G2/M checkpoint stringency is a key parameter in the sensitivity of AML cells to genotoxic stress.

1 reference

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7 July 2018

Hepatocellular carcinoma: epidemiology and molecular carcinogenesis

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7 July 2018

Phase I and pharmacokinetic study of UCN-01 in combination with irinotecan in patients with solid tumors

1 reference

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7 July 2018

Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity

1 reference

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7 July 2018

Genetic instability in cancer cells by impaired cell cycle checkpoints

1 reference

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7 July 2018

Cell cycle regulatory kinase modulators: interim progress and issues

1 reference

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7 July 2018

Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage

1 reference

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7 July 2018

The broad-range cyclin-dependent kinase inhibitor UCN-01 induces apoptosis in colon carcinoma cells through transcriptional suppression of the Bcl-x(L) protein.

1 reference

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7 July 2018

G2 checkpoint abrogators as anticancer drugs

1 reference

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7 July 2018

DNA damage-triggered apoptosis: critical role of DNA repair, double-strand breaks, cell proliferation and signaling

1 reference

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7 July 2018

The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer

1 reference

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ATM and related protein kinases: safeguarding genome integrity

1 reference

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7 July 2018

Apoptosis and the response to anticancer therapy.

1 reference

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7 July 2018

Cell cycle checkpoint signaling through the ATM and ATR kinases

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7 July 2018

Resistance to growth inhibitory and apoptotic effects of phorbol ester and UCN-01 in aggressive cancer cell lines

1 reference

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7 July 2018

Cyclin-dependent kinase inhibitors: novel anticancer agents

1 reference

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7 July 2018

Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma: a randomised trial

1 reference

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7 July 2018

The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

1 reference

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7 July 2018

G1-checkpoint function including a cyclin-dependent kinase 2 regulatory pathway as potential determinant of 7-hydroxystaurosporine (UCN-01)-induced apoptosis and G1-phase accumulation

1 reference

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7 July 2018

Molecular determinants of UCN-01-induced growth inhibition in human lung cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618254

7 July 2018

UCN-01 in ovary cancer cells: effective as a single agent and in combination with cis-diamminedichloroplatinum(II)independent of p53 status.

1 reference

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Induction of p53-dependent and p53-independent cellular responses by topoisomerase 1 inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618254

7 July 2018

Cyclin-dependent kinases: engines, clocks, and microprocessors

1 reference

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Cdk inhibitors: on the threshold of checkpoints and development

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7 July 2018

UCN-01, a selective inhibitor of protein kinase C from Streptomyces.

1 reference

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7 July 2018

Cell cycle control by p53 in normal (3T3) and chemically transformed (Meth A) mouse cells. I. Regulation of p53 expression

1 reference

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7 July 2018

p53 interacts with p34cdc2 in mammalian cells: implications for cell cycle control and oncogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618254

7 July 2018

Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618254

7 July 2018

Defective p53 signaling in p53 wild-type tumors attenuates p21waf1 induction and cyclin B repression rendering them sensitive to Chk1 inhibitors that abrogate DNA damage-induced S and G2 arrest

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-13-167

21 January 2018

Interferon-alpha delays S-phase progression in human hepatocellular carcinoma cells via inhibition of specific cyclin-dependent kinases.

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-13-167

21 January 2018

UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-13-167

21 January 2018

UCN-01 (7-hydoxystaurosporine) inhibits in vivo growth of human cancer cells through selective perturbation of G1 phase checkpoint machinery

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-13-167

21 January 2018

Hepatocyte growth factor induces invasion and migration of ovarian cancer cells by decreasing the expression of E-cadherin, beta-catenin, and caveolin-1.

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-13-167

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Transcriptional activation of the beta-catenin gene at the invasion front of colorectal liver metastases.

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-13-167

21 January 2018

Liver resection for hepatocellular carcinoma on cirrhosis: univariate and multivariate analysis of risk factors for intrahepatic recurrence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618254

26 October 2018

Abrogation of the Chk1-mediated G(2) checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3618254

26 October 2018

Molecular aspects of the mammalian cell cycle and cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/23537372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancement of antitumor activity of mitomycin C in vitro and in vivo by UCN-01, a selective inhibitor of protein kinase C

1 reference

https://pubmed.ncbi.nlm.nih.gov/23537372

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based on heuristic

inferred from PubMed ID database lookup

UCN-01, an anti-tumor drug, is a selective inhibitor of the conventional PKC subfamily

1 reference

https://pubmed.ncbi.nlm.nih.gov/23537372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differing effects of staurosporine and UCN-01 on RB protein phosphorylation and expression of lung cancer cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/23537372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23537372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of UCN-01, staurosporine and CGP 41 251 on cell cycle progression and CDC2/cyclin B1 regulation in A431 cells synchronized at M phase by nocodazole

1 reference

https://pubmed.ncbi.nlm.nih.gov/23537372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1186/1471-2407-13-167

1 reference

Europe PubMed Central

3 August 2017

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1 reference

Europe PubMed Central

3 August 2017

1 reference

Europe PubMed Central

3 August 2017

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