Deficiency of ATP13A2 leads to lysosomal dysfunction, α-synuclein accumulation, and neurotoxicity (Q34636872)

3 August 2017

Deficiency of ATP13A2 leads to lysosomal dysfunction, α-synuclein accumulation, and neurotoxicity (English)

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3 August 2017

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Marija Usenovic

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3 August 2017

Emilie Tresse

2

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3 August 2017

Joseph R Mazzulli

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3 August 2017

J Paul Taylor

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3 August 2017

Dimitri Krainc

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3 August 2017

language of work or name

English

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publication date

1 March 2012

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3 August 2017

Journal of Neuroscience

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3 August 2017

32

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3 August 2017

12

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3 August 2017

4240-4246

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describes a project that uses

3 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3462811/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Regulation of intracellular manganese homeostasis by Kufor-Rakeb syndrome-associated ATP13A2 protein

7 July 2018

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Clarifying lysosomal storage diseases

7 July 2018

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Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

7 July 2018

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Pathogenic effects of novel mutations in the P-type ATPase ATP13A2 (PARK9) causing Kufor-Rakeb syndrome, a form of early-onset parkinsonism

7 July 2018

1 reference

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VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD

7 July 2018

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Acetylation targets mutant huntingtin to autophagosomes for degradation

7 July 2018

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Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity

7 July 2018

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7 July 2018

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Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

7 July 2018

1 reference

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Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection

7 July 2018

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Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking.

7 July 2018

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7 July 2018

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Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model

7 July 2018

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Autophagy and neurodegeneration: when the cleaning crew goes on strike

7 July 2018

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Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

7 July 2018

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7 July 2018

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Kufor Rakeb disease: autosomal recessive, levodopa-responsive parkinsonism with pyramidal degeneration, supranuclear gaze palsy, and dementia

7 July 2018

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Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

7 July 2018

1 reference

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alpha-Synuclein locus triplication causes Parkinson's disease

7 July 2018

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

7 July 2018

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7 July 2018

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Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

7 July 2018

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7 July 2018

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7 July 2018

1 reference

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Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans.

26 October 2018

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α-Synuclein Is Degraded by Both Autophagy and the Proteasome

26 October 2018

1 reference

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Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

26 October 2018

1 reference

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10.1523/JNEUROSCI.5575-11.2012

26 October 2018

Identifiers

DOI

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3 August 2017

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3 August 2017

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