Interleukin-15:Interleukin-15 receptor α scaffold for creation of multivalent targeted immune molecules (Q34626998)

3 August 2017

title

Interleukin-15:Interleukin-15 receptor α scaffold for creation of multivalent targeted immune molecules (English)

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3 August 2017

0 references

Richard L Wong

1

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3 August 2017

Bai Liu

2

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3 August 2017

Xiaoyun Zhu

3

1 reference

3 August 2017

Lijing You

4

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3 August 2017

Lin Kong

5

1 reference

3 August 2017

Kai-Ping Han

6

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3 August 2017

Hyung-Il Lee

7

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3 August 2017

Pierre-Andre Chavaillaz

8

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3 August 2017

Moonsoo Jin

9

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3 August 2017

Yi Wang

10

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3 August 2017

Peter R Rhode

11

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3 August 2017

Hing C Wong

12

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3 August 2017

publication date

21 December 2010

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Protein Engineering Design and Selection

3 August 2017

published in

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3 August 2017

volume

24

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3 August 2017

issue

4

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3 August 2017

page(s)

373-383

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Novel human interleukin-15 agonists

3 August 2017

cites work

1 reference

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Interleukin-15/interleukin-15R alpha complexes promote destruction of established tumors by reviving tumor-resident CD8+ T cells

7 July 2018

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7 July 2018

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Preassociation of IL-15 with IL-15R alpha-IgG1-Fc enhances its activity on proliferation of NK and CD8+/CD44high T cells and its antitumor action

7 July 2018

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7 July 2018

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Intracellular interaction of interleukin-15 with its receptor alpha during production leads to mutual stabilization and increased bioactivity

7 July 2018

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High-affinity TCRs generated by phage display provide CD4+ T cells with the ability to recognize and kill tumor cell lines.

7 July 2018

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Crystal structure of the IL-15-IL-15Ralpha complex, a cytokine-receptor unit presented in trans

7 July 2018

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Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo

7 July 2018

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PEGylation and multimerization of the anti-p185HER-2 single chain Fv fragment 4D5: effects on tumor targeting

7 July 2018

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The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design

7 July 2018

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Potent antitumor activity of a tumor-specific soluble TCR/IL-2 fusion protein

7 July 2018

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Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}

7 July 2018

1 reference

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Visualization of p53(264-272)/HLA-A*0201 complexes naturally presented on tumor cell surface by a multimeric soluble single-chain T cell receptor

7 July 2018

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Single variable domain-IgG fusion. A novel recombinant approach to Fc domain-containing bispecific antibodies

7 July 2018

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An antagonist mutant IL-15/Fc promotes transplant tolerance

7 July 2018

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Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma. Hyperagonist IL-15 x IL-15R alpha fusion proteins

7 July 2018

1 reference

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Engineered antibody fragments and the rise of single domains

7 July 2018

1 reference

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CD8 kinetically promotes ligand binding to the T-cell antigen receptor.

7 July 2018

1 reference

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In vitro and in vivo characterization of a novel antibody-like single-chain TCR human IgG1 fusion protein

7 July 2018

1 reference

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Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis.

7 July 2018

1 reference

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CD8beta endows CD8 with efficient coreceptor function by coupling T cell receptor/CD3 to raft-associated CD8/p56(lck) complexes

7 July 2018

1 reference

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Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands.

7 July 2018

1 reference

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Structure of the complex between human T-cell receptor, viral peptide and HLA-A2

7 July 2018

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Leucine zipper dimerized bivalent and bispecific scFv antibodies from a semi-synthetic antibody phage display library

7 July 2018

1 reference

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Targeting p53 as a general tumor antigen

7 July 2018

1 reference

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T cell receptor antagonist peptides induce positive selection

7 July 2018

1 reference

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Mediation by HLA-DM of dissociation of peptides from HLA-DR

7 July 2018

1 reference

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The role of the leucine zipper in the fos-jun interaction

7 July 2018

1 reference

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Expression of T Cell Antigen Receptor Heterodimers in a Lipid-Linked Form

7 July 2018

1 reference

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HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049345

Formation of a bispecific antibody by the use of leucine zippers

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049345

The human class II MHC protein HLA-DR1 assembles as empty alpha beta heterodimers in the absence of antigenic peptide

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049345

Construction and production of an IgG-like tetravalent bispecific antibody for enhanced therapeutic efficacy.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049345

Targeting activity of a TCR/IL-2 fusion protein against established tumors

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049345

Building better magic bullets--improving unconjugated monoclonal antibody therapy for cancer.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049345

High-level expression of proteins in mammalian cells using transcription regulatory sequences from the Chinese hamster EF-1alpha gene

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049345

The Sushi domain of soluble IL-15 receptor alpha is essential for binding IL-15 and inhibiting inflammatory and allogenic responses in vitro and in vivo.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049345

Different T Cell Receptor Affinity Thresholds and CD8 Coreceptor Dependence Govern Cytotoxic T Lymphocyte Activation and Tetramer Binding Properties

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049345

The Antibody-Mediated Targeted Delivery of Interleukin-15 and GM-CSF to the Tumor Neovasculature Inhibits Tumor Growth and Metastasis

9 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3049345

Expression, purification, and functional analysis of murine ectodomain fragments of CD8alphaalpha and CD8alphabeta dimers

9 December 2018

1 reference

12 December 2020

Molecular applications of fusions to leucine zippers

1 reference

12 December 2020

Mouse MHC class I tetramers that are unable to bind to CD8 reveal the need for CD8 engagement in order to activate naive CD8 T cells

1 reference

12 December 2020

A soluble single-chain T-cell receptor IL-2 fusion protein retains MHC-restricted peptide specificity and IL-2 bioactivity

1 reference

12 December 2020

Solubilizing the T-cell receptor--problems in solution

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12 December 2020

Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists

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12 December 2020

Impact of CD8-MHC class I interaction in detection and sorting efficiencies of antigen-specific T cells using MHC class I/peptide multimers: contribution of pMHC valency

1 reference

12 December 2020

T cell receptor engagement of peptide-major histocompatibility complex class I does not modify CD8 binding

1 reference

12 December 2020

Identifiers

DOI

10.1093/PROTEIN/GZQ116

1 reference

3 August 2017

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3 August 2017

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