Unusual sugar biosynthesis and natural product glycodiversification (Q34623021)

3 August 2017

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title

Unusual sugar biosynthesis and natural product glycodiversification (English)

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3 August 2017

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Christopher J Thibodeaux

series ordinal

1

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3 August 2017

Charles E Melançon

series ordinal

2

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3 August 2017

Hung-wen Liu

series ordinal

3

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3 August 2017

language of work or name

English

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publication date

1 April 2007

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3 August 2017

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3 August 2017

446

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3 August 2017

1008-1016

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3 August 2017

7139

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https://scigraph.springernature.com/pub.10.1038/nature05814

3 August 2017

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Structure, mechanism and engineering of a nucleotidylyltransferase as a first step toward glycorandomization

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Novel enzymatic mechanisms in carbohydrate metabolism

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Formation of unusual sugars: mechanistic studies and biosynthetic applications

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7 January 2021

Mechanisms of enzymatic CbondO bond cleavages in deoxyhexose biosynthesis

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7 January 2021

Biosynthesis of TDP-D-desosamine: identification of a strategy for C4 deoxygenation

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7 January 2021

Short-chain dehydrogenases/reductases (SDR): the 2002 update

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7 January 2021

The Leloir pathway: a mechanistic imperative for three enzymes to change the stereochemical configuration of a single carbon in galactose.

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7 January 2021

Molecular structure of the NADH/UDP-glucose abortive complex of UDP-galactose 4-epimerase from Escherichia coli: implications for the catalytic mechanism

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7 January 2021

Dismutase activity of ADP-L-glycero-D-manno-heptose 6-epimerase: evidence for a direct oxidation/reduction mechanism

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7 January 2021

Structure and function of GDP-mannose-3',5'-epimerase: an enzyme which performs three chemical reactions at the same active site

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7 January 2021

Crystal structure of SQD1, an enzyme involved in the biosynthesis of the plant sulfolipid headgroup donor UDP-sulfoquinovose

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7 January 2021

Recombinant Arabidopsis SQD1 converts udp-glucose and sulfite to the sulfolipid head group precursor UDP-sulfoquinovose in vitro.

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7 January 2021

Recent structural insights into the expanding world of carbohydrate-active enzymes

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7 January 2021

An evolving hierarchical family classification for glycosyltransferases

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7 January 2021

Glycosyltransferase structure and mechanism

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7 January 2021

Glycoside hydrolases and glycosyltransferases: families and functional modules

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Structural and functional features of glycosyltransferases

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7 January 2021

X-ray crystal structure of leukocyte type core 2 beta1,6-N-acetylglucosaminyltransferase. Evidence for a convergence of metal ion-independent glycosyltransferase mechanism

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7 January 2021

Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analog

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7 January 2021

Mechanism and specificity of human alpha-1,3-fucosyltransferase V.

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7 January 2021

Remarkable structural similarities between diverse glycosyltransferases

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7 January 2021

Catalytic mechanism of enzymic glycosyl transfer

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7 January 2021

Insights into trehalose synthesis provided by the structure of the retaining glucosyltransferase OtsA

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7 January 2021

Crystal structure of beta 1,3-glucuronyltransferase I in complex with active donor substrate UDP-GlcUA

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7 January 2021

Structure of the nucleotide-diphospho-sugar transferase, SpsA from Bacillus subtilis, in native and nucleotide-complexed forms

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7 January 2021

Three-dimensional structures of the Mn and Mg dTDP complexes of the family GT-2 glycosyltransferase SpsA: a comparison with related NDP-sugar glycosyltransferases

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7 January 2021

Intermediate trapping on a mutant retaining alpha-galactosyltransferase identifies an unexpected aspartate residue

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7 January 2021

Crystal structure of the retaining galactosyltransferase LgtC from Neisseria meningitidis in complex with donor and acceptor sugar analogs

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7 January 2021

Crystal structure of an alpha 1,4-N-acetylhexosaminyltransferase (EXTL2), a member of the exostosin gene family involved in heparan sulfate biosynthesis

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7 January 2021

Structure of UDP complex of UDP-galactose:beta-galactoside-alpha -1,3-galactosyltransferase at 1.53-A resolution reveals a conformational change in the catalytically important C terminus

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7 January 2021

Structural basis of ordered binding of donor and acceptor substrates to the retaining glycosyltransferase, alpha-1,3-galactosyltransferase

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7 January 2021

Mechanistic studies of a retaining alpha-galactosyltransferase from Neisseria meningitidis.

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7 January 2021

Roles of individual enzyme-substrate interactions by alpha-1,3-galactosyltransferase in catalysis and specificity

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7 January 2021

Substrate specificity of the macrolide-glycosylating enzyme pair DesVII/DesVIII: opportunities, limitations, and mechanistic hypotheses

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7 January 2021

Linear aglycones are the substrates for glycosyltransferase DesVII in methymycin biosynthesis: analysis and implications

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7 January 2021

In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides

1 reference

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7 January 2021

AknT is an activating protein for the glycosyltransferase AknS in L-aminodeoxysugar transfer to the aglycone of aclacinomycin A.

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7 January 2021

Characterization of the biosynthetic gene cluster of rebeccamycin from Lechevalieria aerocolonigenes ATCC 39243.

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7 January 2021

Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine: sugar donor substrate flexibility of the StaG glycosyltransferase

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7 January 2021

Deciphering indolocarbazole and enediyne aminodideoxypentose biosynthesis through comparative genomics: insights from the AT2433 biosynthetic locus.

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7 January 2021

N-linked glycosylation in Campylobacter jejuni and its functional transfer into E. coli

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7 January 2021

Bioactive C-glycosides from bacterial secondary metabolism

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7 January 2021

The hedamycin locus implicates a novel aromatic PKS priming mechanism.

1 reference

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7 January 2021

Biology and biochemistry of glucosinolates

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7 January 2021

Arabidopsis glucosyltransferase UGT74B1 functions in glucosinolate biosynthesis and auxin homeostasis

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7 January 2021

Biological variation of microbial metabolites by precursor-directed biosynthesis

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7 January 2021

Mutational biosynthesis--a tool for the generation of structural diversity in the biosynthesis of antibiotics

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7 January 2021

Production of hybrid glycopeptide antibiotics in vitro and in Streptomyces toyocaensis

1 reference

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7 January 2021

Production of the antitumor drug epirubicin (4'-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

Biosynthesis of Desosamine: Construction of a New Methymycin/Neomethymycin Analogue by Deletion of a Desosamine Biosynthetic Gene

1 reference

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7 January 2021

Study of C-4 deoxygenation in the biosynthesis of desosamine: evidence implicating a novel mechanism

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

Biosynthesis of desosamine: construction of a new macrolide carrying a genetically designed sugar moiety

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

TDP-mycaminose biosynthetic pathway revised and conversion of desosamine pathway to mycaminose pathway with one gene

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

Construction of desosamine containing polyketide libraries using a glycosyltransferase with broad substrate specificity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

Novel Genetically Engineered Tetracenomycins

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

Novel Hybrid Tetracenomycins through Combinatorial Biosynthesis Using a Glycosyltransferase Encoded by theelmGenes in Cosmid 16F4 and Which Shows a Broad Sugar Substrate Specificity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

Engineering deoxysugar biosynthetic pathways from antibiotic-producing microorganisms. A tool to produce novel glycosylated bioactive compounds

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

Digitoxosyltetracenomycin C and glucosyltetracenomycin C, two novel elloramycin analogues obtained by exploring the sugar donor substrate specificity of glycosyltransferase ElmGT.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

Engineering biosynthetic pathways for deoxysugars: branched-chain sugar pathways and derivatives from the antitumor tetracenomycin.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

RebG- and RebM-catalyzed indolocarbazole diversification

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

Combinatorial biosynthesis of antitumor indolocarbazole compounds

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

Elucidation of the function of two glycosyltransferase genes (lanGT1 and lanGT4) involved in landomycin biosynthesis and generation of new oligosaccharide antibiotics

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

Insights about the biosynthesis of the avermectin deoxysugar L-oleandrose through heterologous expression of Streptomyces avermitilis deoxysugar genes in Streptomyces lividans

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

A defined system for hybrid macrolide biosynthesis in Saccharopolyspora erythraea.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

Engineered urdamycin glycosyltransferases are broadened and altered in substrate specificity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

Two sequence elements of glycosyltransferases involved in urdamycin biosynthesis are responsible for substrate specificity and enzymatic activity.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

Enabling glycosyltransferase evolution: a facile substrate-attachment strategy for phage-display enzyme evolution

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

High-throughput screening methodology for the directed evolution of glycosyltransferases

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

Structure of the UDP-glucosyltransferase GtfB that modifies the heptapeptide aglycone in the biosynthesis of vancomycin group antibiotics

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

Structure of the TDP-epi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

Crystal structure of vancosaminyltransferase GtfD from the vancomycin biosynthetic pathway: interactions with acceptor and nucleotide ligands

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

Structure of a flavonoid glucosyltransferase reveals the basis for plant natural product modification

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

Antibiotic optimization via in vitro glycorandomization

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

Substrate specificity of NovM: implications for novobiocin biosynthesis and glycorandomization

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

Exploiting the reversibility of natural product glycosyltransferase-catalyzed reactions

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

Glyco-stripping and glyco-swapping

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

Synthesis and antibacterial activity of mechanism-based inhibitors of KDO8P synthase and DAH7P synthase.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

Chemical probes of UDP-galactopyranose mutase

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

Recent advances in the formation of the bacterial peptidoglycan monomer unit

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

Structure and function of the Mur enzymes: development of novel inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

Structural insight into the transglycosylation step of bacterial cell-wall biosynthesis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05814

7 January 2021

Identifiers

DOI

10.1038/NATURE05814

1 reference

3 August 2017

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