The reductive hotspot hypothesis of mammalian aging: membrane metabolism magnifies mutant mitochondrial mischief (Q34621576)

3 August 2017

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title

The reductive hotspot hypothesis of mammalian aging: membrane metabolism magnifies mutant mitochondrial mischief (English)

1 reference

3 August 2017

Aubrey D N J de Grey

1

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PubMed ID

11985576

3 August 2017

language of work or name

English

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publication date

1 April 2002

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3 August 2017

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3 August 2017

269

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3 August 2017

8

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3 August 2017

2003-2009

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The biologic clock: the mitochondria?

3 August 2017

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02868.X

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Low mitochondrial free radical production per unit O2 consumption can explain the simultaneous presence of high longevity and high aerobic metabolic rate in birds.

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Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

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Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia

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The position of aging studies

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A proposed refinement of the mitochondrial free radical theory of aging

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The mtDNA-encoded ND6 subunit of mitochondrial NADH dehydrogenase is essential for the assembly of the membrane arm and the respiratory function of the enzyme

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Cytochrome c oxidase defects of the human substantia nigra in normal aging.

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Detection of a specific mitochondrial DNA deletion in tissues of older humans

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Both heavy strand replication origins are active in partially duplicated human mitochondrial DNAs

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Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication

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The reductive hotspot hypothesis: an update

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Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation

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Studies on the active transfer of reducing equivalents into mitochondria via the malate-aspartate shuttle

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Kinetics of hemin distribution in plasma reveals its role in lipoprotein oxidation

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Maternal Pumilio acts together with Nanos in germline development in Drosophila embryos

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High rates of extracellular superoxide generation by cultured human fibroblasts: involvement of a lipid-metabolizing enzyme.

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Role of cytochrome b5 reductase on the antioxidant function of coenzyme Q in the plasma membrane

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Surface NADH oxidase of HeLa cells lacks intrinsic membrane binding motifs

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High-capacity redox control at the plasma membrane of mammalian cells: trans-membrane, cell surface, and serum NADH-oxidases.

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ADP-regulation of mitochondrial free radical production is different with complex I- or complex II-linked substrates: implications for the exercise paradox and brain hypermetabolism.

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Extracellular superoxide dismutase and other superoxide dismutase isoenzymes in tissues from nine mammalian species

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A multifunctional hydroquinone oxidase of the external cell surface and sera

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Quantitation and origin of the mitochondrial membrane potential in human cells lacking mitochondrial DNA.

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Assembly of functional proton-translocating ATPase complex in yeast mitochondria with cytoplasmically synthesized subunit 8, a polypeptide normally encoded within the organelle

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Response to "approaches and limitations to gene therapy for mitochondrial diseases," Antioxid. Redox Signal. 2001;3:451-460.

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The typically mitochondrial DNA-encoded ATP6 subunit of the F1F0-ATPase is encoded by a nuclear gene in Chlamydomonas reinhardtii.

21 January 2018

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Use of the NADH-quinone oxidoreductase (NDI1) gene of Saccharomyces cerevisiae as a possible cure for complex I defects in human cells

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Absence of Relationship between the Level of Electron Transport Chain Activities and Aging in Human Skeletal Muscle

21 January 2018

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21 January 2018

Identifiers

DOI

1 reference

3 August 2017

1 reference

PubMed ID

11985576