Indoxyl sulfate, a uremic toxin, downregulates renal expression of Nrf2 through activation of NF-κB. (Q34621513)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23496811%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

title

Indoxyl sulfate, a uremic toxin, downregulates renal expression of Nrf2 through activation of NF-κB (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23496811%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

0 references

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23496811%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

author name string

Dilinaer Bolati

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23496811%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

Maimaiti Yisireyili

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23496811%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

Fuyuhiko Nishijima

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23496811%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

Toshimitsu Niwa

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23496811%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

publication date

4 March 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23496811%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23496811%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

volume

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23496811%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

page(s)

56

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23496811%20AND%20SRC:MED&resulttype=core&format=json

Indoxyl sulfate upregulates renal expression of MCP-1 via production of ROS and activation of NF-κB, p53, ERK, and JNK in proximal tubular cells

26 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599003

Prevention of salt-induced renal injury by activation of NAD(P)H:quinone oxidoreductase 1, associated with NADPH oxidase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599003

NF-κB plays an important role in indoxyl sulfate-induced cellular senescence, fibrotic gene expression, and inhibition of proliferation in proximal tubular cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599003

Bardoxolone methyl and kidney function in CKD with type 2 diabetes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599003

Indoxyl sulfate downregulates renal expression of Klotho through production of ROS and activation of nuclear factor-ĸB.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599003

Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599003

Senescence and dysfunction of proximal tubular cells are associated with activated p53 expression by indoxyl sulfate.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599003

Molecular mechanisms of Nrf2-mediated antioxidant response

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599003

Heme oxygenase-1 deficiency promotes epithelial-mesenchymal transition and renal fibrosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599003

p53 suppresses the Nrf2-dependent transcription of antioxidant response genes.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599003

Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599003

Role of organic anion transporters in the tubular transport of indoxyl sulfate and the induction of its nephrotoxicity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599003

Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3599003

Indoxyl sulfate induces epithelial-to-mesenchymal transition in rat kidneys and human proximal tubular cells.

7 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2F1471-2369-14-56

ROS and PDGF-beta [corrected] receptors are critically involved in indoxyl sulfate actions that promote vascular smooth muscle cell proliferation and migration

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2F1471-2369-14-56

Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2F1471-2369-14-56

An oral sorbent reduces overload of indoxyl sulphate and gene expression of TGF-beta1 in uraemic rat kidneys

21 January 2018

1 reference

12 December 2020

Accumulation of indoxyl sulfate, an inhibitor of drug-binding, in uremic serum as demonstrated by internal-surface reversed-phase liquid chromatography

1 reference

12 December 2020

Inhibitory effect of oral sorbent on accumulation of albumin-bound indoxyl sulfate in serum of experimental uremic rats

1 reference

12 December 2020

Indoxyl sulfate, a circulating uremic toxin, stimulates the progression of glomerular sclerosis

1 reference

12 December 2020

Progression of glomerular sclerosis in experimental uremic rats by administration of indole, a precursor of indoxyl sulfate

1 reference

12 December 2020

Indoxyl sulfate increases the gene expressions of TGF-beta 1, TIMP-1 and pro-alpha 1(I) collagen in uremic rat kidneys

1 reference

12 December 2020

The protein metabolite hypothesis, a model for the progression of renal failure: an oral adsorbent lowers indoxyl sulfate levels in undialyzed uremic patients

1 reference

12 December 2020

Indoxyl sulfate stimulates renal synthesis of transforming growth factor-beta 1 and progression of renal failure

1 reference

12 December 2020

Indoxyl sulphate promotes aortic calcification with expression of osteoblast-specific proteins in hypertensive rats

1 reference

12 December 2020

An oral sorbent, AST-120, increases Klotho expression and inhibits cell senescence in the kidney of uremic rats

1 reference

12 December 2020

Indoxyl sulfate reduces klotho expression and promotes senescence in the kidneys of hypertensive rats

1 reference

12 December 2020

Effect of bardoxolone methyl on kidney function in patients with T2D and Stage 3b-4 CKD

1 reference

12 December 2020

AST-120 ameliorates epithelial-to-mesenchymal transition and interstitial fibrosis in the kidneys of chronic kidney disease rats

1 reference

12 December 2020

Identifiers

DOI

10.1186/1471-2369-14-56

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23496811%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23496811%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23496811%20AND%20SRC:MED&resulttype=core&format=json