Pharmacokinetically guided dose adjustment of 5-fluorouracil: a rational approach to improving therapeutic outcomes (Q34612932)

3 August 2017

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title

Pharmacokinetically guided dose adjustment of 5-fluorouracil: a rational approach to improving therapeutic outcomes (English)

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3 August 2017

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M Wasif Saif

1

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3 August 2017

Adrienne Choma

series ordinal

2

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3 August 2017

Salvatore J Salamone

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3

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3 August 2017

Edward Chu

series ordinal

4

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3 August 2017

language of work or name

English

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publication date

19 October 2009

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Journal of the National Cancer Institute

3 August 2017

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3 August 2017

101

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3 August 2017

22

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3 August 2017

1543-1552

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Clinical response and plasma levels of 5-fluorouracil in patients with colonic cancer treated by drug infusion

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A simple and rapid high-performance liquid chromatographic (HPLC) method for 5-fluorouracil (5-FU) assay in plasma and possible detection of patients with impaired dihydropyrimidine dehydrogenase (DPD) activity

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Quantitation of 5-fluorouracil (5-FU) in human plasma by liquid chromatography/electrospray ionization tandem mass spectrometry

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Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer

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Dose monitoring of 5-fluorouracil in patients with colorectal or head and neck cancer--status of the art.

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Individual fluorouracil dose adjustment based on pharmacokinetic follow-up compared with conventional dosage: results of a multicenter randomized trial of patients with metastatic colorectal cancer

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Individual 5-FU dose adaptation in metastatic colorectal cancer: results of a phase II study using a bimonthly pharmacokinetically intensified LV5FU2 regimen

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Individualizing therapy with 5-fluorouracil related to dihydropyrimidine dehydrogenase: theory and limits

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5-Fluorouracil-related severe toxicity: a comparison of different methods for the pretherapeutic detection of dihydropyrimidine dehydrogenase deficiency

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Importance of dihydropyrimidine dehydrogenase (DPD) deficiency in patients exhibiting toxicity following treatment with 5-fluorouracil

21 January 2018

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Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin

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Immunohistochemical quantitation of thymidylate synthase expression in colorectal cancer metastases predicts for clinical outcome to fluorouracil-based chemotherapy

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Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy

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Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy

21 January 2018

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Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: a prospective clinical trial by the German 5-FU Toxicity Study Group

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Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study.

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Identifiers

DOI

10.1093/JNCI/DJP328

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3 August 2017

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