InterAKTions with FKBPs--mutational and pharmacological exploration (Q34612149)

3 August 2017

InterAKTions with FKBPs--mutational and pharmacological exploration (English)

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3 August 2017

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3

Sonja Neimanis

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Ricardo M Biondi

object named as

Ricardo M Biondi

4

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author name string

Anne-Katrin Fabian

1

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3 August 2017

Andreas März

2

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3 August 2017

Christian Kozany

5

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3 August 2017

Felix Hausch

6

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3 August 2017

language of work or name

English

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publication date

28 February 2013

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3 August 2017

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3 August 2017

8

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3 August 2017

2

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3 August 2017

e57508

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Creative Commons Attribution 4.0 International

3 August 2017

start time

28 February 2013

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Facile synthesis of a fluorescent cyclosporin a analogue to study cyclophilin 40 and cyclophilin 18 ligands

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Large FK506-Binding Proteins Shape the Pharmacology of Rapamycin

7 July 2018

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Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death

7 July 2018

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FKBP5 as a selection biomarker for gemcitabine and Akt inhibitors in treatment of pancreatic cancer

7 July 2018

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An ATP-site on-off switch that restricts phosphatase accessibility of Akt

7 July 2018

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The chemical biology of immunophilin ligands

7 July 2018

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Targeting FKBP isoforms with small-molecule ligands

7 July 2018

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FK506-binding protein 51 is a possible novel tumoral marker

7 July 2018

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mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

7 July 2018

1 reference

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Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition

7 July 2018

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Physiological regulation of Akt activity and stability.

7 July 2018

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The PI3K pathway as drug target in human cancer

7 July 2018

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FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells

7 July 2018

1 reference

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The nuts and bolts of AGC protein kinases

7 July 2018

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FKBP51 and Cyp40 are positive regulators of androgen-dependent prostate cancer cell growth and the targets of FK506 and cyclosporin A.

7 July 2018

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FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt.

7 July 2018

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Inhibitor hijacking of Akt activation

7 July 2018

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Fluorescent probes to characterise FK506-binding proteins

7 July 2018

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A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation

7 July 2018

1 reference

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Role of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibition

7 July 2018

1 reference

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An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

7 July 2018

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Drug discovery approaches targeting the PI3K/Akt pathway in cancer

7 July 2018

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PI3K pathway alterations in cancer: variations on a theme

7 July 2018

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Hsp90 regulates the phosphorylation and activity of serum- and glucocorticoid-regulated kinase-1.

7 July 2018

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FK506 binding protein mediates glioma cell growth and sensitivity to rapamycin treatment by regulating NF-kappaB signaling pathway

7 July 2018

1 reference

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Structure-based classification of 45 FK506-binding proteins

7 July 2018

1 reference

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Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585324

Signal responsiveness of IkappaB kinases is determined by Cdc37-assisted transient interaction with Hsp90.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585324

The immunophilin ligands cyclosporin A and FK506 suppress prostate cancer cell growth by androgen receptor-dependent and -independent mechanisms

7 July 2018

1 reference

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Identification of inhibitors of protein kinase B using fragment-based lead discovery

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585324

PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585324

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

7 July 2018

1 reference

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FK1706, a novel non-immunosuppressive immunophilin: neurotrophic activity and mechanism of action.

7 July 2018

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FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells.

7 July 2018

1 reference

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A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway

7 July 2018

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Akt as a mediator of cell death

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585324

The Hsp90-binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585324

Crystal structure of an inactive Akt2 kinase domain

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585324

Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585324

The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585324

Modulation of Akt kinase activity by binding to Hsp90

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585324

Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585324

Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585324

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585324

Mechanism of activation of protein kinase B by insulin and IGF-1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585324

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585324

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585324

The cytosolic-binding protein for the immunosuppressant FK-506 is both a ubiquitous and highly conserved peptidyl-prolyl cis-trans isomerase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585324

The prospect of FKBP51 as a drug target.

7 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0057508

10.1371/JOURNAL.PONE.0057508

21 January 2018

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DOI

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3 August 2017

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1 reference

3 August 2017

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