Identifying genomic and developmental causes of adverse drug reactions in children (Q34603032)

3 August 2017

1 reference

title

Identifying genomic and developmental causes of adverse drug reactions in children (English)

1 reference

3 August 2017

Mara L Becker

1

1 reference

PubMed ID

21121777

3 August 2017

J Steven Leeder

series ordinal

2

1 reference

3 August 2017

1 November 2010

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3 August 2017

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3 August 2017

11

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3 August 2017

11

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3 August 2017

1591-1602

1 reference

The effect of genotype on methotrexate polyglutamate variability in juvenile idiopathic arthritis and association with drug response.

3 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Understanding developmental pharmacodynamics: importance for drug development and clinical practice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Effectiveness and toxicity of methotrexate in juvenile idiopathic arthritis: comparison of 2 initial dosing regimens.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Analysis of intracellular methotrexate polyglutamates in patients with juvenile idiopathic arthritis: effect of route of administration on variability in intracellular methotrexate polyglutamate concentrations

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Understanding the relative roles of pharmacogenetics and ontogeny in pediatric drug development and regulatory science.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Identification of human UGT2B7 as the major isoform involved in the O-glucuronidation of chloramphenicol

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Activation adverse events induced by the selective serotonin reuptake inhibitor fluvoxamine in children and adolescents

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Adverse drug reactions in hospital in-patients: a prospective analysis of 3695 patient-episodes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

An update on pharmacogenomics in rheumatoid arthritis with a focus on TNF-blocking agents.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Evaluation of a [13C]-dextromethorphan breath test to assess CYP2D6 phenotype

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemia

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Single nucleotide polymorphism discovery and functional assessment of variation in the UDP-glucuronosyltransferase 2B7 gene

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

The ontogeny of drug metabolism enzymes and implications for adverse drug events

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Pediatric rheumatology for the adult rheumatologist

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Development, testing, and findings of a pediatric-focused trigger tool to identify medication-related harm in US children's hospitals

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Incidence of fatal adverse drug reactions: a population based study

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Valproate use in children and adolescents with bipolar disorder

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Pediatric migraine: pharmacologic agents for prophylaxis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Thiopurine metabolite monitoring in paediatric inflammatory bowel disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Ontogeny of dextromethorphan O- and N-demethylation in the first year of life

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Juvenile myoclonic epilepsy: epidemiology, pathophysiology, and management

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Role of valproate across the ages. Treatment of epilepsy in children

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Treatment-emergent adverse events from selective serotonin reuptake inhibitors by age group: children versus adolescents

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Pharmacogenetic and metabolite measurements are associated with clinical status in patients with rheumatoid arthritis treated with methotrexate: results of a multicentred cross sectional observational study

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Folate deprivation results in the loss of breast cancer resistance protein (BCRP/ABCG2) expression. A role for BCRP in cellular folate homeostasis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Developmental pharmacology--drug disposition, action, and therapy in infants and children

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Incidence of adverse drug reactions in paediatric in/out-patients: a systematic review and meta-analysis of prospective studies

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Medication errors and adverse drug events in pediatric inpatients

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Neonatal paroxetine withdrawal syndrome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Adverse drug reactions: definitions, diagnosis, and management

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Glucuronidation in humans. Pharmacogenetic and developmental aspects

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Lamotrigine-associated rash: risk/benefit considerations in adults and children

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

A prospective study of adverse drug reactions in hospitalized children

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Reye's syndrome in the United States from 1981 through 1997.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Risk of serious haematological toxicity with use of chloramphenicol eye drops in a British general practice database

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Selective serotonin reuptake inhibitor-induced serotonin syndrome: review

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Thiopurine methyltransferase activity in a Korean population sample of children.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Valproic acid hepatic fatalities. III. U.S. experience since 1986.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Valproate-induced hepatic injury: analyses of 23 fatal cases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Valproic acid hepatic fatalities: a retrospective review

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Metabolic activation of valproic acid and drug-mediated hepatotoxicity. Role of the terminal olefin, 2-n-propyl-4-pentenoic acid

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Valproic acid hepatic fatalities. II. US experience since 1984.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Identification and characterization of the glutathione and N-acetylcysteine conjugates of (E)-2-propyl-2,4-pentadienoic acid, a toxic metabolite of valproic acid, in rats and humans

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

High incidence of secondary brain tumours after radiotherapy and antimetabolites.

7 July 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.146

Granulocyte colony-stimulating factor and the risk of secondary myeloid malignancy after etoposide treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.146

Multiple-dose pharmacokinetics of fluvoxamine in children and adolescents

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.146

Correlative study of hydrochloric acid, pepsin, and intrinsic factor secretion in newborns and infants

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.146

Physiology of serum gastrin production in neonates and infants.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.146

Severe adverse effects in a newborn with two defective CYP2D6 alleles after exposure to paroxetine during late pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.146

Developmental pharmacogenetics: a general paradigm for application to neonatal pharmacology and toxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.146

Developmental changes in human liver CYP2D6 expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.146

O-demethylation of tramadol in the first months of life.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.146

Phenotype and genotype for thiopurine methyltransferase activity in the French Caucasian population: impact of age.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.146

Valproic acid-induced hepatopathy: nine new fatalities in Germany from 1994 to 2003.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.146

Severe hepatotoxicity during valproate therapy: an update and report of eight new fatalities.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.146

Contribution of common polymorphisms in reduced folate carrier and gamma-glutamylhydrolase to methotrexate polyglutamate levels in patients with rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.146

Pharmacogenomic and metabolic biomarkers in the folate pathway and their association with methotrexate effects during dosage escalation in rheumatoid arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.146

Adverse drug reaction active surveillance: developing a national network in Canada's children's hospitals.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.146

Identification and characterization of N-acetylcysteine conjugates of valproic acid in humans and animals

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Serum sickness-like reactions to cefaclor: role of hepatic metabolism and individual susceptibility.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044438

Infant serotonin transporter (SLC6A4) promoter genotype is associated with adverse neonatal outcomes after prenatal exposure to serotonin reuptake inhibitor medications

26 October 2018

1 reference

12 December 2020

Pediatric drug surveillance and the Food and Drug Administration's adverse event reporting system: an overview of reports, 2003-2007

1 reference

12 December 2020

Gastric retention in neonates

1 reference

12 December 2020

Factors associated with adverse drug reactions in the newborn

1 reference

12 December 2020

Fluoxetine hydrochloride (Prozac) toxicity in a neonate

1 reference

12 December 2020

In vivo formation of the thiol conjugates of reactive metabolites of 4-ene VPA and its analog 4-pentenoic acid

1 reference

12 December 2020

Quantification of dextromethorphan and metabolites: a dual phenotypic marker for cytochrome P450 3A4/5 and 2D6 activity

1 reference

12 December 2020

Potential fluoxetine chloride (Prozac) toxicity in a newborn

1 reference

12 December 2020

Adverse drug reactions (ADRs) in hospitalized pediatric patients. A prospective study

1 reference

12 December 2020

Clinical pharmacology and therapeutic drug monitoring in neonates and children

1 reference

12 December 2020

Studies on the biotransformation in the perfused rat liver of 2-n-propyl-4-pentenoic acid, a metabolite of the antiepileptic drug valproic acid. Evidence for the formation of chemically reactive intermediates

1 reference

12 December 2020

Adverse drug reactions in children leading to hospital admission

1 reference

12 December 2020

Fatal liver failure in 16 children with valproate therapy

1 reference

12 December 2020

Rash in adult and pediatric patients treated with lamotrigine

1 reference

12 December 2020

Gas chromatography/negative ion chemical ionization mass spectrometry and liquid chromatography/electrospray ionization tandem mass spectrometry quantitative profiling of N-acetylcysteine conjugates of valproic acid in urine: application in drug met

1 reference

12 December 2020

Intra-individual variability and influence of urine collection period on dextromethorphan metabolic ratios in healthy subjects

1 reference

12 December 2020

Chloramphenicol toxicity in the premature infant

1 reference

12 December 2020

Chloramphenicol in the newborn infant. A physiologic explanation of its toxicity when given in excessive doses

1 reference

12 December 2020

Fatal circulatory collapse in premature infants receiving chloramphenicol

1 reference

12 December 2020

Identifiers

DOI

10.2217/PGS.10.146

1 reference

3 August 2017

1 reference

3 August 2017

1 reference

PubMed ID

21121777