The molecular basis for anti-proteolytic and non-proteolytic functions of plasminogen activator inhibitor type-1: roles of the reactive centre loop, the shutter region, the flexible joint region and the small serpin fragment (Q34584787)

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English	The molecular basis for anti-proteolytic and non-proteolytic functions of plasminogen activator inhibitor type-1: roles of the reactive centre loop, the shutter region, the flexible joint region and the small serpin fragment	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

3 August 2017

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Europe PubMed Central

The molecular basis for anti-proteolytic and non-proteolytic functions of plasminogen activator inhibitor type-1: roles of the reactive centre loop, the shutter region, the flexible joint region and the small serpin fragment (English)

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Europe PubMed Central

PubMed publication ID

3 August 2017

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based on heuristic

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based on heuristic

inferred from title

author name string

Troels Wind

1

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Europe PubMed Central

PubMed publication ID

3 August 2017

Martin Hansen

2

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Europe PubMed Central

PubMed publication ID

3 August 2017

Jan K Jensen

3

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Europe PubMed Central

PubMed publication ID

3 August 2017

Peter A Andreasen

4

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Europe PubMed Central

PubMed publication ID

3 August 2017

publication date

1 January 2002

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Europe PubMed Central

PubMed publication ID

3 August 2017

Biological Chemistry

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Europe PubMed Central

PubMed publication ID

3 August 2017

383

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Europe PubMed Central

PubMed publication ID

3 August 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

21-36

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

The urokinase-type plasminogen activator system in cancer metastasis: A review

1 reference

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21 January 2018

The plasminogen activation system in tumor growth, invasion, and metastasis

1 reference

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21 January 2018

Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization.

1 reference

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21 January 2018

The plasminogen activator inhibitor PAI-1 controls in vivo tumor vascularization by interaction with proteases, not vitronectin. Implications for antiangiogenic strategies

1 reference

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21 January 2018

Plasminogen activator inhibitor-1 in acute hyperoxic mouse lung injury

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Identification of the binding site for a low-molecular-weight inhibitor of plasminogen activator inhibitor type 1 by site-directed mutagenesis

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Moving membrane up to the front of migrating cells

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Loss of fibrinogen rescues mice from the pleiotropic effects of plasminogen deficiency.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

The pH dependence of serpin-proteinase complex dissociation reveals a mechanism of complex stabilization involving inactive and active conformational states of the proteinase which are perturbable by calcium

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Impaired arterial neointima formation in mice with disruption of the plasminogen gene

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

alpha-2 Macroglobulin receptor/Ldl receptor-related protein(Lrp)-dependent internalization of the urokinase receptor

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Disruption of the plasminogen gene in mice abolishes wound healing after myocardial infarction

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

The variable region-1 from tissue-type plasminogen activator confers specificity for plasminogen activator inhibitor-1 to thrombin by facilitating catalysis: release of a kinetic block by a heterologous protein surface loop

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release?

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

An ester bond linking a fragment of a serine proteinase to its serpin inhibitor.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

A regulatory hydrophobic area in the flexible joint region of plasminogen activator inhibitor-1, defined with fluorescent activity-neutralizing ligands. Ligand-induced serpin polymerization

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

A serpin-induced extensive proteolytic susceptibility of urokinase-type plasminogen activator implicates distortion of the proteinase substrate-binding pocket and oxyanion hole in the serpin inhibitory mechanism

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Peptide-mediated inactivation of recombinant and platelet plasminogen activator inhibitor-1 in vitro

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Topography of a 2.0 Å structure of α1-antitrypsin reveals targets for rational drug design to prevent conformational disease

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Conformational studies of plasminogen activator inhibitor type 1 by fluorescence spectroscopy. Analysis of the reactive centre of inhibitory and substrate forms, and of their respective reactive-centre cleaved forms.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Substrate behavior of plasminogen activator inhibitor-1 is not associated with a lack of insertion of the reactive site loop.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Importance of the amino-acid composition of the shutter region of plasminogen activator inhibitor-1 for its transitions to latent and substrate forms

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

The crystal structure of plasminogen activator inhibitor 2 at 2.0 A resolution: implications for serpin function

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Structure of a serpin-protease complex shows inhibition by deformation

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Role of Lys335 in the metastability and function of inhibitory serpins

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

The plasminogen activator system: biology and regulation

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Phylogeny of the serpin superfamily: implications of patterns of amino acid conservation for structure and function.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Effects of serpin binding on the target proteinase: global stabilization, localized increased structural flexibility, and conserved hydrogen bonding at the active site.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Plasminogen activator inhibitor-1 represses integrin- and vitronectin-mediated cell migration independently of its function as an inhibitor of plasminogen activation

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

The urokinase plasminogen activator receptor in the regulation of the actin cytoskeleton and cell motility

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Extending the capabilities of targeted molecular dynamics: simulation of a large conformational transition in plasminogen activator inhibitor 1.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

The acid stabilization of plasminogen activator inhibitor-1 depends on protonation of a single group that affects loop insertion into beta-sheet A.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Influence of plasminogen activator inhibitor type 1 on choroidal neovascularization

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Engineering plasminogen activator inhibitor 1 mutants with increased functional stability.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Partitioning of serpin-proteinase reactions between stable inhibition and substrate cleavage is regulated by the rate of serpin reactive center loop insertion into beta-sheet A.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Mutations which impede loop/sheet polymerization enhance the secretion of human alpha 1-antitrypsin deficiency variants

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Serpin-resistant mutants of human tissue-type plasminogen activator

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Amino acid residues that affect interaction of tissue-type plasminogen activator with plasminogen activator inhibitor 1

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Control of type IV collagenase activity by components of the urokinase-plasmin system: a regulatory mechanism with cell-bound reactants.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Structural basis of latency in plasminogen activator inhibitor-1

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Interconversions between active, inert and substrate forms of denatured/refolded type-1 plasminogen activator inhibitor

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Localization of epitopes for monoclonal antibodies to urokinase-type plasminogen activator: relationship between epitope localization and effects of antibodies on molecular interactions of the enzyme

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Insight into the mechanism of serpin-proteinase inhibition from 2D [1H-15N] NMR studies of the 69 kDa alpha 1-proteinase inhibitor Pittsburgh-trypsin covalent complex

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Role of vitronectin and its receptors in haemostasis and vascular remodeling

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Plasminogen activator inhibitor type 1 is a potential target in renal fibrogenesis

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Mutant mice with scrambled brains: understanding the signaling pathways that control cell positioning in the CNS.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Plasminogen activators and plasminogen activator inhibitors: biochemical aspects

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Purification and characterization of active and stable recombinant plasminogen-activator inhibitor accumulated at high levels in Escherichia coli.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Cloning, expression and mapping of a novel human zinc-finger gene TCF17 homologous to rodent Kid1.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

The active conformation of plasminogen activator inhibitor 1, a target for drugs to control fibrinolysis and cell adhesion

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

A fluorescent probe study of plasminogen activator inhibitor-1. Evidence for reactive center loop insertion and its role in the inhibitory mechanism

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Introduction of an RRHR motif into chicken urokinase-type plasminogen activator (ch-uPA) confers sensitivity to plasminogen activator inhibitor (PAI)-1 and PAI-2 and allows ch-uPA-mediated extracellular matrix degradation to be controlled by PAI-1

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Structural change in alpha-chymotrypsin induced by complexation with alpha 1-antichymotrypsin as seen by enhanced sensitivity to proteolysis.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

The serpin PAI-1 inhibits cell migration by blocking integrin alpha V beta 3 binding to vitronectin

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Serpin tertiary structure transformation

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Different structural requirements for plasminogen activator inhibitor 1 (PAI-1) during latency transition and proteinase inhibition as evidenced by phage-displayed hypermutated PAI-1 libraries

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Structures of active and latent PAI-1: a possible stabilizing role for chloride ions

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 A and full insertion of the reactive center loop into beta-sheet A.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Intrinsic fluorescence changes and rapid kinetics of proteinase deformation during serpin inhibition

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Neuronal death in the central nervous system demonstrates a non-fibrin substrate for plasmin

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Engineering of plasminogen activator inhibitor-1 to reduce the rate of latency transition

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

A substrate-like form of plasminogen-activator-inhibitor type 1. Conversions between different forms by sodium dodecyl sulphate

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Sequential dephosphorylation of p34(cdc2) on Thr-14 and Tyr-15 at the prophase/metaphase transition

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Plasmin and plasminogen activator inhibitor type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Plasminogen activator inhibitor 1 functions as a urokinase response modifier at the level of cell signaling and thereby promotes MCF-7 cell growth

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Conformational changes in serpins: I. The native and cleaved conformations of alpha(1)-antitrypsin

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

The inhibition mechanism of serpins. Evidence that the mobile reactive center loop is cleaved in the native protease-inhibitor complex.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Epitope mapping for four monoclonal antibodies against human plasminogen activator inhibitor type-1: implications for antibody-mediated PAI-1-neutralization and vitronectin-binding

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

The structure of a Michaelis serpin-protease complex

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

The low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor regulates cell surface plasminogen activator activity on human trophoblast cells

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Vitronectin is not essential for normal mammalian development and fertility.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Polymerization of plasminogen activator inhibitor-1.

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Physiological consequences of loss of plasminogen activator gene function in mice

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Development of venous occlusions in mice transgenic for the plasminogen activator inhibitor-1 gene

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.003

21 January 2018

Identifiers

10.1515/BC.2002.003

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

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