Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites (Q34582058)

3 August 2017

Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites (English)

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3 August 2017

transmembrane protein

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4

Trevor G Smart

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3 August 2017

2

Megan E Wilkins

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3 August 2017

1

Alastair M Hosie

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3 August 2017

Helena M A da Silva

3

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PubMed ID

17108970

3 August 2017

language of work or name

English

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publication date

15 November 2006

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3 August 2017

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3 August 2017

444

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486-489

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7118

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https://scigraph.springernature.com/pub.10.1038/nature05324

3 August 2017

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cites work

Neurosteroids: endogenous regulators of the GABA(A) receptor

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Is there a physiological role for the neurosteroid THDOC in stress-sensitive conditions?

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Neurosteroid biosynthesis in the human brain and its clinical implications

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Ethanol regulation of gamma-aminobutyric acid A receptors: genomic and nongenomic mechanisms

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Pathogenesis in menstrual cycle-linked CNS disorders

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The role of pregnane neurosteroids in ethanol withdrawal: behavioral genetic approaches

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Neuroactive steroids as modulators of depression and anxiety

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Neuroactive Steroids are Altered in Schizophrenia and Bipolar Disorder: Relevance to Pathophysiology and Therapeutics

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Formation and plasticity of GABAergic synapses: physiological mechanisms and pathophysiological implications.

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Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain

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The effects of inhibitors of GABAergic transmission and stress on brain and plasma allopregnanolone concentrations

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Neurosteroid prolongs GABAA channel deactivation by altering kinetics of desensitized states

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7 January 2021

Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors

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The contraceptive agent Provera enhances GABA(A) receptor-mediated inhibitory neurotransmission in the rat hippocampus: evidence for endogenous neurosteroids?

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7 January 2021

Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor

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7 January 2021

Neurosteroids act on the GABA(A) receptor at sites on the N-terminal side of the middle of TM2.

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7 January 2021

Neurosteroid access to the GABAA receptor

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7 January 2021

Sites of positive allosteric modulation by neurosteroids on ionotropic gamma-aminobutyric acid receptor subunits

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7 January 2021

Cloning and functional expression of a Drosophila gamma-aminobutyric acid receptor

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Crystal structure of human sex hormone-binding globulin: steroid transport by a laminin G-like domain

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Molecular basis of agonism and antagonism in the oestrogen receptor

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Structure and gating mechanism of the acetylcholine receptor pore

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Gamma-aminobutyric acid increases the water accessibility of M3 membrane-spanning segment residues in gamma-aminobutyric acid type A receptors

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Channel gating of the glycine receptor changes accessibility to residues implicated in receptor potentiation by alcohols and anesthetics

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Functional and structural analysis of the GABAA receptor alpha 1 subunit during channel gating and alcohol modulation

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SWISS-MODEL: An automated protein homology-modeling server

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Comparative modeling of a GABAA alpha1 receptor using three crystal structures as templates

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Identifiers

DOI

10.1038/NATURE05324

1 reference

PubMed ID

17108970

Dimensions Publication ID

3 August 2017

0 references

1 reference

PubMed ID

17108970