Orally administered diflunisal stabilizes transthyretin against dissociation required for amyloidogenesis (Q34581917)

3 August 2017

Orally administered diflunisal stabilizes transthyretin against dissociation required for amyloidogenesis (English)

1 reference

3 August 2017

3

Jeffery W Kelly

1 reference

3 August 2017

Yoshiki Sekijima

1

1 reference

PubMed ID

17107884

3 August 2017

Maria A Dendle

series ordinal

2

1 reference

3 August 2017

1 December 2006

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3 August 2017

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3 August 2017

13

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3 August 2017

236-249

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3 August 2017

4

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Partial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro

3 August 2017

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Alternative conformations of amyloidogenic proteins govern their behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Amyloid fibril formation and protein misassembly: a structural quest for insights into amyloid and prion diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

The acid-mediated denaturation pathway of transthyretin yields a conformational intermediate that can self-assemble into amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Trans-suppression of misfolding in an amyloid disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Prevention of transthyretin amyloid disease by changing protein misfolding energetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Inhibiting transthyretin amyloid fibril formation via protein stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Inhibiting transthyretin conformational changes that lead to amyloid fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: a focus on the transthyretin amyloidoses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Synthesis and evaluation of inhibitors of transthyretin amyloid formation based on the non-steroidal anti-inflammatory drug, flufenamic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Synthesis, structure, and activity of diclofenac analogues as transthyretin amyloid fibril formation inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Synthesis and characterization of potent bivalent amyloidosis inhibitors that bind prior to transthyretin tetramerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Design, synthesis, and evaluation of oxazole transthyretin amyloidogenesis inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Evaluating the binding selectivity of transthyretin amyloid fibril inhibitors in blood plasma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Native state stabilization by NSAIDs inhibits transthyretin amyloidogenesis from the most common familial disease variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Diflunisal: a review of pharmacokinetic and pharmacodynamic properties, drug interactions, and special tolerability studies in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

The chemistry, pharmacology and clinical pharmacology of diflunisal

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Kinetic stabilization of an oligomeric protein under physiological conditions demonstrated by a lack of subunit exchange: implications for transthyretin amyloidosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Kinetic stabilization of an oligomeric protein by a single ligand binding event

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Kinetic stabilization of the native state by protein engineering: implications for inhibition of transthyretin amyloidogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Sequence-dependent denaturation energetics: A major determinant in amyloid disease diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

The most pathogenic transthyretin variant, L55P, forms amyloid fibrils under acidic conditions and protofilaments under physiological conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Transthyretin aggregation under partially denaturing conditions is a downhill polymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

In vitro and in vivo interactions of homocysteine with human plasma transthyretin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Revised transthyretin Ile 122 allele frequency in African-Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Variant-sequence transthyretin (isoleucine 122) in late-onset cardiac amyloidosis in black Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

The biological and chemical basis for tissue-selective amyloid disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Serum transthyretin monomer in patients with familial amyloid polyneuropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Transthyretin isoleucine-122 mutation in African and American blacks

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Clinical improvement and amyloid regression after liver transplantation in hereditary transthyretin amyloidosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Long-term follow-up of survival of liver transplant recipients with familial amyloid polyneuropathy (Portuguese type)

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

D18G transthyretin is monomeric, aggregation prone, and not detectable in plasma and cerebrospinal fluid: a prescription for central nervous system amyloidosis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

A different amyloid formation mechanism: de novo oculoleptomeningeal amyloid deposits after liver transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Deposition of transthyretin in early stages of familial amyloidotic polyneuropathy: evidence for toxicity of nonfibrillar aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Tissue damage in the amyloidoses: Transthyretin monomers and nonnative oligomers are the major cytotoxic species in tissue culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Metabolism of prealbumin in rats and changes induced by acute inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivative

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Mice transgenic for human TTR have the same frequency of renal TTR deposition whether maintained in conventional or specific pathogen free environments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Evidence for early cytotoxic aggregates in transgenic mice for human transthyretin Leu55Pro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Cysteine 10 is a key residue in amyloidogenesis of human transthyretin Val30Met

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Tabulation of human transthyretin (TTR) variants, 2003

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

Impact of age and amyloidosis on thiol conjugation of transthyretin in hereditary transthyretin amyloidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13506120600960882

10.1080/13506120600960882

21 January 2018

Identifiers

DOI

1 reference

3 August 2017

1 reference

PubMed ID

17107884