Prediction of intestinal permeability (Q34581541)

3 August 2017

1 reference

title

Prediction of intestinal permeability (English)

1 reference

3 August 2017

William J Egan

1

1 reference

PubMed ID

11922948

3 August 2017

Georgio Lauri

series ordinal

2

1 reference

PubMed ID

11922948

3 August 2017

language of work or name

English

0 references

publication date

1 March 2002

1 reference

Advanced Drug Delivery Reviews

3 August 2017

1 reference

3 August 2017

54

1 reference

3 August 2017

273-289

1 reference

3 August 2017

3

1 reference

Drug, meal and formulation interactions influencing drug absorption after oral administration. Clinical implications

3 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Effects of food on clinical pharmacokinetics

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Review of theoretical passive drug absorption models: historical background, recent developments and limitations

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

The fluid mosaic model of the structure of cell membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Human jejunal effective permeability and its correlation with preclinical drug absorption models

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Partition coefficients and their uses

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Linear Relationships between Lipophilic Character and Biological Activity of Drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Lipophilic Character and Biological Activity of Drugs II: The Parabolic Case

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Multivariate analysis of experimental and computational descriptors of molecular lipophilicity

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

A practitioner's perspective of the role of quantitative structure-activity analysis in medicinal chemistry

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

A Novel Method for Measuring Membrane-Water Partition Coefficients of Hydrophobic Organic Chemicals: Comparison with 1-Octanol–Water Partitioning

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Patterns of non-electrolyte permeability.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Absorption prediction from physicochemical parameters

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Computational methods for the prediction of 'drug-likeness'

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Property-based design: optimization of drug absorption and pharmacokinetics

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Virtual screening of intestinal drug permeability

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Prediction of intestinal absorption and blood-brain barrier penetration by computational methods

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Property distribution of drug-related chemical databases.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Polar molecular surface properties predict the intestinal absorption of drugs in humans.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Correlation of drug absorption with molecular surface properties

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Evaluation of dynamic polar molecular surface area as predictor of drug absorption: comparison with other computational and experimental predictors

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Experimental and computational screening models for the prediction of intestinal drug absorption

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 1. Prediction of intestinal absorption

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Polar molecular surface as a dominating determinant for oral absorption and brain penetration of drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Prediction of membrane permeability to peptides from calculated dynamic molecular surface properties

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Cell permeability as a parameter for lead generation in the protein Tyrosine kinase inhibition field

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Prediction of polar surface area and drug transport processes using simple parameters and PLS statistics

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Theoretical calculation and prediction of drug transport processes using simple parameters and partial least squares projections to latent structures (PLS) statistics. The use of electrotopological state indices

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Computation of the physio-chemical properties and data mining of large molecular collections

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

A widely applicable set of descriptors

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Hydrogen Bond Structural Group Constants

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Theoretical calculation and prediction of Caco-2 cell permeability using MolSurf parametrization and PLS statistics

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Theoretical calculation and prediction of intestinal absorption of drugs in humans using MolSurf parametrization and PLS statistics

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Prediction of human intestinal absorption of drug compounds from molecular structure.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

VolSurf: a new tool for the pharmacokinetic optimization of lead compounds

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Theoretical hydrogen bonding parameters for drug design.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Prediction of drug transport processes using simple parameters and PLS statistics. The use of ACD/logP and ACD/ChemSketch descriptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Toward minimalistic modeling of oral drug absorption.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Prediction of drug absorption using multivariate statistics

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure-activity relationship (QSAR) with the Abraham descriptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Caco-2 cell permeability vs human gastrointestinal absorption: QSPR analysis.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Structure-property model for membrane partitioning of oligopeptides

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

High-throughput approaches for evaluating absorption, distribution, metabolism and excretion properties of lead compounds

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Gastrointestinal absorption of drugs: methods and studies

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Current methodologies used for evaluation of intestinal permeability and absorption

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

MDCK (Madin-Darby canine kidney) cells: A tool for membrane permeability screening

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Comparison of HT29-18-C1 and Caco-2 cell lines as models for studying intestinal paracellular drug absorption.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Correlating partitioning and caco-2 cell permeability of structurally diverse small molecular weight compounds.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Linear correlation of the fraction of oral dose absorbed of 64 drugs between humans and rats

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man--fact or myth

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Comparison of the permeability characteristics of a human colonic epithelial (Caco-2) cell line to colon of rabbit, monkey, and dog intestine and human drug absorption

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Optimized conditions for prediction of intestinal drug permeability using Caco-2 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Evaluation of an accelerated Caco-2 cell permeability model.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Drug-like properties and the causes of poor solubility and poor permeability

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Effect of solubilizing excipients on permeation of poorly water-soluble compounds across Caco-2 cell monolayers

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Guidance in the setting of drug particle size specifications to minimize variability in absorption.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Carrier-mediated intestinal transport of drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Minimal molecular determinants of substrates for recognition by the intestinal peptide transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

A family of drug transporters: the multidrug resistance-associated proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

The multidrug resistance protein family.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

The gut as a barrier to drug absorption: combined role of cytochrome P450 3A and P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

A general pattern for substrate recognition by P-glycoprotein.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Structure-activity relationship of P-glycoprotein substrates and modifiers.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Substrate recognition by P-glycoprotein and the multidrug resistance-associated protein MRP1: a comparison.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Role of P-glycoprotein-mediated secretion in absorptive drug permeability: An approach using passive membrane permeability and affinity to P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Oral bioavailability of digoxin is enhanced by talinolol: evidence for involvement of intestinal P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Use of immobilized artificial membrane chromatography for drug transport applications

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Drug liposome partitioning as a tool for the prediction of human passive intestinal absorption

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Solid-supported lipid membranes as a tool for determination of membrane affinity: high-throughput screening of a physicochemical parameter

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

HT29-MTX and Caco-2/TC7 monolayers as predictive models for human intestinal absorption: role of the mucus layer

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Outlier detection in multivariate analytical chemical data

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

The Mahalanobis distance

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

The Hat Matrix in Regression and ANOVA

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

Enhancing the hit-to-lead properties of lead optimization libraries

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2802%2900004-2

7 January 2021

10.1016/S0169-409X(02)00004-2

Identifiers

DOI

1 reference

3 August 2017

1 reference

PubMed ID

11922948