Cancer chemoresistance: the relationship between p53 and multidrug transporters (Q34580489)

3 August 2017

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title

Cancer chemoresistance: the relationship between p53 and multidrug transporters (English)

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3 August 2017

multiple drug resistance

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Jason A Bush

1

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PubMed ID

11920581

3 August 2017

Gang Li

series ordinal

2

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PubMed ID

11920581

3 August 2017

language of work or name

English

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publication date

1 March 2002

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International Journal of Cancer

3 August 2017

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3 August 2017

98

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3 August 2017

323-330

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3 August 2017

3

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Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs

3 August 2017

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Modulation of activity of the promoter of the human MDR1 gene by Ras and p53.

21 January 2018

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Regulation of expression of the multidrug resistance protein MRP1 by p53 in human prostate cancer cells

21 January 2018

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Cloning and initial analysis of the human multidrug resistance-related MVP/LRP gene promoter

21 January 2018

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The human ATP-binding cassette (ABC) transporter superfamily

21 January 2018

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Multidrug resistance transporters and modulation

21 January 2018

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A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

21 January 2018

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Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells

21 January 2018

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Gene expression and amplification in breast carcinoma cells with intrinsic and acquired doxorubicin resistance

21 January 2018

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The human multidrug resistance-associated protein (MRP) gene family: from biological function to drug molecular design

21 January 2018

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Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily

21 January 2018

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A multidrug resistance transporter from human MCF-7 breast cancer cells

21 January 2018

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Selection and characterization of a high-activity ribozyme directed against the antineoplastic drug resistance-associated ABC transporter BCRP/MXR/ABCG2.

21 January 2018

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The drug resistance-related protein LRP is the human major vault protein

21 January 2018

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Isolation and characterization of a novel ribonucleoprotein particle: large structures contain a single species of small RNA

21 January 2018

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Lung resistance-related protein/major vault protein and vaults in multidrug-resistant cancer

21 January 2018

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The region 3' to the major transcriptional start site of the MDR1 downstream promoter mediates activation by a subset of mutant P53 proteins

21 January 2018

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Characterization of the promoter region of the human MDR3 P-glycoprotein gene

21 January 2018

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Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor.

21 January 2018

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The human multidrug resistance protein 2 gene: functional characterization of the 5'-flanking region and expression in hepatic cells

21 January 2018

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Characterization of the 5'-flanking region of the human multidrug resistance protein 2 (MRP2) gene and its regulation in comparison withthe multidrug resistance protein 3 (MRP3) gene

21 January 2018

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Characterization of 5'-flanking region of human MRP3

21 January 2018

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Twenty years of p53 research: structural and functional aspects of the p53 protein

21 January 2018

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NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription

21 January 2018

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DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1.

21 January 2018

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Definition of a consensus binding site for p53

21 January 2018

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A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

21 January 2018

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The p53-mdm-2 autoregulatory feedback loop

21 January 2018

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The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

21 January 2018

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Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

21 January 2018

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PUMA, a novel proapoptotic gene, is induced by p53

21 January 2018

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Apaf-1 is a transcriptional target for E2F and p53

21 January 2018

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p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs

21 January 2018

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Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis

21 January 2018

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The MDR1 downstream promoter contains sequence-specific binding sites for wild-type p53.

21 January 2018

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Mutant p53 cooperates with ETS and selectively up-regulates human MDR1 not MRP1.

21 January 2018

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Induction of wild-type p53 activity in human cancer cells by ribozymes that repair mutant p53 transcripts

21 January 2018

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Wild Type p53 Stimulates Expression from the Human Multidrug Resistance Promoter in a p53-negative Cell Line

21 January 2018

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Aromatic hydrocarbon receptor (AhR).AhR nuclear translocator- and p53-mediated induction of the murine multidrug resistance mdr1 gene by 3-methylcholanthrene and benzo(a)pyrene in hepatoma cells

21 January 2018

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Wild-type p53-mediated induction of rat mdr1b expression by the anticancer drug daunorubicin

21 January 2018

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Wild-type p53 gene increases MDR1 gene expression but decreases drug resistance in an MDR cell line KBV200.

21 January 2018

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p53 mutational spectra and the role of methylated CpG sequences

21 January 2018

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Gain of function mutations in p53.

21 January 2018

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'Gain of function' phenotype of tumor-derived mutant p53 requires the oligomerization/nonsequence-specific nucleic acid-binding domain

21 January 2018

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p53 mutants without a functional tetramerisation domain are not oncogenic

21 January 2018

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Cellular characterisation of p53 mutants with a single missense mutation in the beta-strand 326-333 and correlation of their cellular activities with in vitro properties.

21 January 2018

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Transcriptional repression by p53 through direct binding to a novel DNA element

21 January 2018

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p53-dependent regulation of MDR1 gene expression causes selective resistance to chemotherapeutic agents

21 January 2018

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p53-dependent apoptosis in melanoma cells after treatment with camptothecin

21 January 2018

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Differential sensitivities of the MRP gene family and gamma-glutamylcysteine synthetase to prooxidants in human colorectal carcinoma cell lines with different p53 status

21 January 2018

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p53 and P-glycoprotein are often co-expressed and are associated with poor prognosis in breast cancer

21 January 2018

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Quantitative immunocytochemical assays of P-glycoprotein in breast carcinomas: correlation to messenger RNA expression and to immunohistochemical prognostic indicators.

21 January 2018

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Application of an original RT-PCR-ELISA multiplex assay for MDR1 and MRP, along with p53 determination in node-positive breast cancer patients

21 January 2018

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The co-expression of p53 protein and P-glycoprotein is correlated to a poor prognosis in osteosarcoma

21 January 2018

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P-glycoprotein is not expressed in a majority of colorectal carcinomas and is not regulated by mutant p53 in vivo

21 January 2018

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Expression of lung resistance protein and correlation with other drug resistance proteins and outcome in myelodysplastic syndromes.

21 January 2018

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MBR rearrangement and P-glycoprotein expression are not independent prognostic factors like p53 protein in malignant lymphoma.

21 January 2018

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Expression of P-glycoprotein, a multidrug-resistance gene product, is induced by radiotherapy in patients with oral squamous cell carcinoma.

21 January 2018

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Expression of P-glycoprotein in hepatocellular carcinoma: a potential marker of prognosis

21 January 2018

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Expression of P-glycoprotein and p53 in advanced hepatocellular carcinoma treated by single agent chemotherapy: clinical correlation

21 January 2018

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Expression of P-glycoprotein in hepatocellular carcinoma. A determinant of chemotherapy response

21 January 2018

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Expression of multidrug resistance related proteins and proliferative activity is increased in advanced clinical prostate cancer

21 January 2018

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Multidrug resistance-associated protein (MRP) expression is correlated with expression of aberrant p53 protein in colorectal cancer.

21 January 2018

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Immunohistochemical analysis of drug resistance-associated proteins in ovarian carcinomas.

21 January 2018

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Mdr1b facilitates p53-mediated cell death and p53 is required for Mdr1b upregulation in vivo

21 January 2018

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Adenovirus-mediated wild-type p53 gene expression radiosensitizes non-small cell lung cancer cells but not normal lung fibroblasts

21 January 2018

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Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IJC.10226

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3 August 2017

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PubMed ID

11920581