Clinical trials of immunomodulatory therapies in severe sepsis and septic shock (Q34577529)

3 August 2017

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title

Clinical trials of immunomodulatory therapies in severe sepsis and septic shock (English)

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3 August 2017

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1

Jean-Louis Vincent

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3 August 2017

Qinghua Sun

2

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PubMed ID

11914997

3 August 2017

Marc-Jacques Dubois

series ordinal

3

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PubMed ID

11914997

3 August 2017

language of work or name

English

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publication date

12 March 2002

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Clinical Infectious Diseases

3 August 2017

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3 August 2017

34

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3 August 2017

1084-1093

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3 August 2017

8

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Treatment of gram-negative bacteremia and shock with human antiserum to a mutant Escherichia coli

3 August 2017

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Prevention of gram-negative shock and death in surgical patients by antibody to endotoxin core glycolipid.

21 January 2018

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A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis. The XOMA Sepsis Study Group

21 January 2018

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Treatment of septic shock with human monoclonal antibody HA-1A. A randomized, double-blind, placebo-controlled trial. CHESS Trial Study Group.

21 January 2018

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Recombinant bactericidal/permeability-increasing protein (rBPI21) as adjunctive treatment for children with severe meningococcal sepsis: a randomised trial. rBPI21 Meningococcal Sepsis Study Group

21 January 2018

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Effect of hemoperfusion with polymyxin B-immobilized fiber on plasma endothelin-1 and endothelin-1 mRNA in monocytes from patients with sepsis

21 January 2018

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Therapeutic efficacy of a polymyxin B-dextran 70 conjugate in experimental model of endotoxemia

21 January 2018

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Polymyxin-dextran antiendotoxin pretreatment in an ovine model of normotensive sepsis.

21 January 2018

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Effect of high-dose glucocorticoid therapy on mortality in patients with clinical signs of systemic sepsis

21 January 2018

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A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock

21 January 2018

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Steroid controversy in sepsis and septic shock: a meta-analysis

21 January 2018

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Corticosteroid treatment for sepsis: a critical appraisal and meta-analysis of the literature.

21 January 2018

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Reduction of Mortality in Chloramphenicol-Treated Severe Typhoid Fever by High-Dose Dexamethasone

21 January 2018

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Reversal of late septic shock with supraphysiologic doses of hydrocortisone

21 January 2018

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INTERSEPT: an international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis. International Sepsis Trial Study Group.

21 January 2018

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Randomized, placebo-controlled trial of the anti-tumor necrosis factor antibody fragment afelimomab in hyperinflammatory response during severe sepsis: The RAMSES Study

21 January 2018

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Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition

21 January 2018

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Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator Group

21 January 2018

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Septic shock, multiple organ failure, and disseminated intravascular coagulation. Compared patterns of antithrombin III, protein C, and protein S deficiencies

21 January 2018

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Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial

21 January 2018

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Replacement therapy with protein C concentrate in infants and adolescents with meningococcal sepsis and purpura fulminans.

21 January 2018

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Efficacy and safety of recombinant human activated protein C for severe sepsis

21 January 2018

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Proteolytic inactivation of plasma C1- inhibitor in sepsis

21 January 2018

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Randomized double-blind, multicenter study of prostaglandin E1 in patients with the adult respiratory distress syndrome. Prostaglandin E1 Study Group

21 January 2018

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Endogenously opsonized particles divert prostanoid action from lethal to protective in models of experimental endotoxemia.

21 January 2018

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A multi-centre, double-blind, placebo-controlled study of liposomal prostaglandin E1 (TLC C-53) in patients with acute respiratory distress syndrome

21 January 2018

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The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group

21 January 2018

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N-acetylcysteine in experimental and clinical acute lung injury

21 January 2018

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N-acetylcysteine enhances recovery from acute lung injury in man. A randomized, double-blind, placebo-controlled clinical study.

21 January 2018

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The effects of intravenous antioxidants in patients with septic shock.

21 January 2018

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Treatment with N-acetylcysteine during acute respiratory distress syndrome: a randomized, double-blind, placebo-controlled clinical study.

21 January 2018

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Selenium replacement in patients with severe systemic inflammatory response syndrome improves clinical outcome.

21 January 2018

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Comparison of the effects of aminoguanidine and N omega-nitro-L-arginine methyl ester on the multiple organ dysfunction caused by endotoxaemia in the rat.

21 January 2018

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Methylene blue reverses endotoxin-induced hypotension

21 January 2018

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Methylene blue increases myocardial function in septic shock.

21 January 2018

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Methylene blue administration in septic shock: a clinical trial.

21 January 2018

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Short-term effects of methylene blue on hemodynamics and gas exchange in humans with septic shock.

21 January 2018

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Administration of an antibody to E-selectin in patients with septic shock.

21 January 2018

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High volume hemofiltration improves right ventricular function in endotoxin-induced shock in the pig.

21 January 2018

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Continuous venovenous hemofiltration improves cardiac performance by mechanisms other than tumor necrosis factor-alpha attenuation during endotoxic shock.

21 January 2018

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Immunonutrition in the critically ill.

21 January 2018

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Effect of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in patients with acute respiratory distress syndrome. Enteral Nutrition in ARDS Study Group.

21 January 2018

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A randomized trial of isonitrogenous enteral diets after severe trauma. An immune-enhancing diet reduces septic complications.

21 January 2018

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Randomised trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma

21 January 2018

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Monocyte deactivation--rationale for a new therapeutic strategy in sepsis

21 January 2018

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Granulocyte colony-stimulating factor in the treatment of high-risk febrile neutropenia: a multicenter randomized trial.

21 January 2018

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Filgrastim in patients with pneumonia and severe sepsis or septic shock

21 January 2018

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A randomized controlled trial of filgrastim as an adjunct to antibiotics for treatment of hospitalized patients with community-acquired pneumonia. CAP Study Group.

21 January 2018

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Effect of prophylactic administration of recombinant human granulocyte colony-stimulating factor (filgrastim) on the frequency of nosocomial infections in patients with acute traumatic brain injury or cerebral hemorrhage. The Filgrastim Study Group.

21 January 2018

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A phase II multicenter, double-blind, randomized, placebo-controlled study of three dosages of an immunomodulator (PGG-glucan) in high-risk surgical patients

21 January 2018

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Randomized phase I/II trial of a macrophage-specific immunomodulator (PGG-glucan) in high-risk surgical patients

21 January 2018

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Effect of PGG-glucan on the Rate of Serious Postoperative Infection or Death Observed After High-Risk Gastrointestinal Operations

21 January 2018

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Adjunctive therapy in sepsis: a critical analysis of the clinical trial programme

21 January 2018

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Assessment of ability of murine and human anti-lipid A monoclonal antibodies to bind and neutralize lipopolysaccharide

21 January 2018

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Prevention of Jarisch-Herxheimer reactions by treatment with antibodies against tumor necrosis factor alpha

21 January 2018

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HMG-1 as a late mediator of endotoxin lethality in mice

21 January 2018

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Sepsis and serum cytokine concentrations.

21 January 2018

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Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock: a multicenter, randomized, placebo-controlled, dose-ranging study.

21 January 2018

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Antithrombin III (ATIII) replacement therapy in patients with sepsis and/or postsurgical complications: a controlled double-blind, randomized, multicenter study.

21 January 2018

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Administration of anti-TNF antibody improves left ventricular function in septic shock patients. Results of a pilot study

21 January 2018

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An open-label dose escalation study of the nitric oxide synthase inhibitor, N(G)-methyl-L-arginine hydrochloride (546C88), in patients with septic shock. Glaxo Wellcome International Septic Shock Study Group.

21 January 2018

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4G/5G promoter polymorphism in the plasminogen-activator-inhibitor-1 gene and outcome of meningococcal disease

21 January 2018

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Liposomal prostaglandin E sub 1 in acute respiratory distress syndrome

21 January 2018

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Effects of N-acetylcysteine on tissue oxygenation in patients with multiple organ failure and evidence of tissue hypoxia

21 January 2018

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21 January 2018

Identifiers

DOI

10.1086/339549

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3 August 2017

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PubMed ID

11914997