Population pharmacokinetics and pharmacodynamics of BYL719, a phosphoinositide 3-kinase antagonist, in adult patients with advanced solid malignancies (Q34571048)

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Language	Label	Description	Also known as
English	Population pharmacokinetics and pharmacodynamics of BYL719, a phosphoinositide 3-kinase antagonist, in adult patients with advanced solid malignancies	scientific article

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scholarly article

1 reference

3 August 2017

Population pharmacokinetics and pharmacodynamics of BYL719, a phosphoinositide 3-kinase antagonist, in adult patients with advanced solid malignancies (English)

1 reference

3 August 2017

pharmacokinetics

1 reference

based on heuristic

inferred from title

pharmacodynamics

1 reference

based on heuristic

inferred from title

Annamária Jakab

2

object named as

Annamaria Jakab

1 reference

3 August 2017

author name string

Stefan S De Buck

1

1 reference

3 August 2017

Markus Boehm

3

1 reference

3 August 2017

Douglas Bootle

4

1 reference

3 August 2017

Dejan Juric

5

1 reference

3 August 2017

Cornelia Quadt

6

1 reference

3 August 2017

Timothy K Goggin

7

1 reference

3 August 2017

language of work or name

0 references

publication date

1 September 2014

1 reference

3 August 2017

British Journal of Clinical Pharmacology

1 reference

3 August 2017

78

1 reference

3 August 2017

543-555

1 reference

3 August 2017

3

1 reference

3 August 2017

Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation

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7 July 2018

Clinical development of phosphatidylinositol 3-kinase inhibitors for cancer treatment

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7 July 2018

PI3K and mTOR signaling pathways in cancer: new data on targeted therapies

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7 July 2018

The PI3K pathway as drug target in human cancer

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7 July 2018

Targeting the phosphoinositide 3-kinase pathway in cancer

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7 July 2018

Elucidation of relationship between tumor size and survival in non-small-cell lung cancer patients can aid early decision making in clinical drug development

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7 July 2018

New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)

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Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.

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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

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7 July 2018

Human tumor mutants in the p110alpha subunit of PI3K.

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7 July 2018

Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells

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7 July 2018

Functional analysis of PIK3CA gene mutations in human colorectal cancer

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7 July 2018

High frequency of mutations of the PIK3CA gene in human cancers

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PI3K in lymphocyte development, differentiation and activation

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7 July 2018

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

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7 July 2018

Inhibition of phosphatidylinositol 3'-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models.

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7 July 2018

Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.

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7 July 2018

Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation

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Pharmacokinetic/pharmacodynamic modeling in drug research and development.

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7 July 2018

Phosphoinositide kinases

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7 July 2018

The impact of lag time on the estimation of pharmacokinetic parameters. I. One-compartment open model

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Clearance approaches in pharmacology.

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7 July 2018

Implementation of a transit compartment model for describing drug absorption in pharmacokinetic studies.

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21 January 2018

Implementation of dose superimposition to introduce multiple doses for a mathematical absorption model (transit compartment model).

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21 January 2018

On the use of change in tumor size to predict survival in clinical oncology studies: toward a new paradigm to design and evaluate phase II studies.

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21 January 2018

Model-based prediction of phase III overall survival in colorectal cancer on the basis of phase II tumor dynamics.

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21 January 2018

A pharmacodynamic model for the time course of tumor shrinkage by gemcitabine + carboplatin in non-small cell lung cancer patients.

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21 January 2018

Phosphatidylinositol 3-kinase suppresses glucose-stimulated insulin secretion by affecting post-cytosolic [Ca(2+)] elevation signals

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21 January 2018

A link between insulin resistance and hyperinsulinemia: inhibitors of phosphatidylinositol 3-kinase augment glucose-induced insulin secretion from islets of lean, but not obese, rats.

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27 October 2018

Optimizing the science of drug development: opportunities for better candidate selection and accelerated evaluation in humans

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/BCP.12378

1 reference

3 August 2017

1 reference

3 August 2017

1 reference

3 August 2017

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