O6-alkylguanine-DNA alkyltransferase: role in carcinogenesis and chemotherapy (Q34561510)

3 August 2017

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title

O6-alkylguanine-DNA alkyltransferase: role in carcinogenesis and chemotherapy (English)

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3 August 2017

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Geoffrey P Margison

1

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PubMed ID

11891762

3 August 2017

Mauro F Santibáñez-Koref

series ordinal

2

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PubMed ID

11891762

3 August 2017

language of work or name

English

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publication date

1 March 2002

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3 August 2017

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3 August 2017

24

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3 August 2017

255-266

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3 August 2017

3

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Understanding and manipulating O6-methylguanine-DNA methyltransferase expression

3 August 2017

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https://api.crossref.org/works/10.1002%2FBIES.10063

DNA adducts: endogenous and induced

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10063

Specific excision of methylation products from DNA of Escherichia coli treated with N-methyl-N′-nitro-N-nitrosoguanidine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10063

Comparative Studies of the Hepatocarcinogen N,N-Dimethylnitrosamine in vivo: Reaction Sites in Rat Liver DNA and the Significance of their Relative Stabilities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10063

Conserved structural motifs governing the stoichiometric repair of alkylated DNA by O(6)-alkylguanine-DNA alkyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10063

Reaction and binding of oligodeoxynucleotides containing analogues of O6-methylguanine with wild-type and mutant human O6-alkylguanine-DNA alkyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10063

Ubiquitination-dependent proteolysis of O6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10063

Implication of localization of human DNA repair enzyme O6-methylguanine-DNA methyltransferase at active transcription sites in transcription-repair coupling of the mutagenic O6-methylguanine lesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10063

Fast repair of O6-ethylguanine, but not O6-methylguanine, in transcribed genes prevents mutation of H-ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10063

Mammalian DNA repair methyltransferases shield O4MeT from nucleotide excision repair.

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.10063

Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.10063

Alkylation-induced apoptosis of embryonic stem cells in which the gene for DNA-repair, methyltransferase, had been disrupted by gene targeting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10063

A role for mismatch repair in production of chromosome aberrations by methylating agents in human cells

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.10063

On the quantitative relationship between O6-methylguanine residues in genomic DNA and production of sister-chromatid exchanges, mutations and lethal events in a Mer- human tumor cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10063

Bacterial and mammalian DNA alkyltransferases sensitize Escherichia coli to the lethal and mutagenic effects of dibromoalkanes.

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.10063

O6-methylguanine inhibits the binding of transcription factors to DNA.

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.10063

O6-methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.10063

Increased susceptibility to chemotherapeutic alkylating agents of mice deficient in DNA repair methyltransferase

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.10063

Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10063

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10063

Kinetics of incorporation of O6-methyldeoxyguanosine monophosphate during in vitro DNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10063

Lack of induction of O6-methylguanine-DNA methyltransferase in mammalian cells treated with N-methyl-N'-nitro-N-nitrosoguanidine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10063

p53 is involved in regulation of the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) by DNA damaging agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10063

Interferon inducers increase O6-alkylguanine-DNA alkyltransferase in the rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10063

Regulation of the human O(6)-methylguanine-DNA methyltransferase gene by transcriptional coactivators cAMP response element-binding protein-binding protein and p300.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10063

Changes in O6-methylguanine-DNA methyltransferase expression during immortalization of cloned human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10063

Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10063

Cytoplasmic sequestration of an O6-methylguanine-DNA methyltransferase enhancer binding protein in DNA repair-deficient human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10063

Aberrant silencing of the CpG island-containing human O6-methylguanine DNA methyltransferase gene is associated with the loss of nucleosome-like positioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10063

Nonenzymatic methylation of DNA by S-adenosylmethionine in vitro.

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.10063

Nitrosated peptides and polyamines as endogenous mutagens in O6-alkylguanine-DNA alkyltransferase deficient cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10063

DNA mismatch repair mutants do not increase N-methyl-N'-nitro-N-nitrosoguanidine tolerance in O6-methylguanine DNA methyltransferase-deficient yeast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10063

A phylogenomic study of DNA repair genes, proteins, and processes

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.10063

Molecular analysis of O6-substituted guanine-induced mutagenesis of ras oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10063

N-nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras1 gene mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10063

O6-methylguanine-DNA methyltransferase in pretreatment tumour biopsies as a predictor of response to temozolomide in melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10063

Immunohistological examination of the inter- and intracellular distribution of O6-alkylguanine DNA-alkyltransferase in human liver and melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10063

Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10063

A novel dual function retrovirus expressing multidrug resistance 1 and O6-alkylguanine-DNA-alkyltransferase for engineering resistance of haemopoietic progenitor cells to multiple chemotherapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10063

Exhaustion and recovery of repair excision of O6-methylguanine from rat liver DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10063

O 6-Methylguanine-DNA methyltransferase activity and induction of novel immunogenicity in murine tumor cells treated with methylating agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10063

21 January 2018

Identifiers

DOI

10.1002/BIES.10063

1 reference

3 August 2017

1 reference

PubMed ID

11891762