Gamma-secretase: never more enigmatic (Q34553814)

3 August 2017

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title

Gamma-secretase: never more enigmatic (English)

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3 August 2017

Sisodia SS

1

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3 August 2017

Annaert W

series ordinal

2

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3 August 2017

Kim SH

series ordinal

3

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3 August 2017

De Strooper B

series ordinal

4

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3 August 2017

1 November 2001

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3 August 2017

Trends in Neurosciences

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3 August 2017

24

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3 August 2017

11 Suppl

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3 August 2017

S2-6

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Mutant genes in familial Alzheimer's disease and transgenic models

3 August 2017

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

Abeta-generating enzymes: recent advances in beta- and gamma-secretase research

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

The role of presenilins in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

Evidence for phosphorylation and oligomeric assembly of presenilin 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

Subcellular localization of presenilins: association with a unique membrane pool in cultured cells

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

Effects of PS1 deficiency on membrane protein trafficking in neurons.

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

A common enzyme connects notch signaling and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

Notch and presenilins in vertebrates and invertebrates: implications for neuronal development and degeneration

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

The type 4 prepilin peptidases comprise a novel family of aspartic acid proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

In search of gamma-secretase: presenilin at the cutting edge

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

Altered metabolism of familial Alzheimer's disease-linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

Presenilin mutations line up along transmembrane alpha-helices.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

Transport-Dependent Proteolysis of SREBP

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901987-1

7 January 2021

10.1016/S0166-2236(00)01987-1

Identifiers

DOI

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3 August 2017

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