A novel notch protein, N2N, targeted by neutrophil elastase and implicated in hereditary neutropenia (Q34551427)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14673143%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

title

A novel notch protein, N2N, targeted by neutrophil elastase and implicated in hereditary neutropenia (English)

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22 December 2019

7

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22 December 2019

4

Kimberly Meade-White

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22 December 2019

author name string

Zhijun Duan

1

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22 December 2019

Feng-Qian Li

2

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22 December 2019

Jeremy Wechsler

3

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22 December 2019

Kayleen Williams

5

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22 December 2019

Kathleen F Benson

6

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22 December 2019

language of work or name

English

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publication date

1 January 2004

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Molecular and Cellular Biology

22 December 2019

published in

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22 December 2019

volume

24

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22 December 2019

issue

1

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22 December 2019

page(s)

58-70

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Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development

22 December 2019

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1 reference

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Role of neutrophil elastase in bone marrow failure syndromes: molecular genetic revival of the chalone hypothesis

7 July 2018

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Processing of the human transferrin receptor at distinct positions within the stalk region by neutrophil elastase and cathepsin G.

7 July 2018

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Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling

7 July 2018

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The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila

7 July 2018

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The notch pathway: modulation of cell fate decisions in hematopoiesis

7 July 2018

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Nonsense mutations in ADTB3A cause complete deficiency of the beta3A subunit of adaptor complex-3 and severe Hermansky-Pudlak syndrome type 2

7 July 2018

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Notch receptors and hematopoiesis

7 July 2018

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Soluble Jagged 1 represses the function of its transmembrane form to induce the formation of the Src-dependent chord-like phenotype

7 July 2018

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Constitutively activating mutation in WASP causes X-linked severe congenital neutropenia

7 July 2018

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Specificity of Cdk activation in vivo by the two Caks Mcs6 and Csk1 in fission yeast.

7 July 2018

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Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation

7 July 2018

1 reference

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Notch signaling enhances survival and alters differentiation of 32D myeloblasts

7 July 2018

1 reference

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Notch signalling via RBP-J promotes myeloid differentiation.

7 July 2018

1 reference

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The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression

7 July 2018

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Elastase substrate specificity tailored through substrate-assisted catalysis and phage display

7 July 2018

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Mutations in ELA2, encoding neutrophil elastase, define a 21-day biological clock in cyclic haematopoiesis.

7 July 2018

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Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality.

7 July 2018

1 reference

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PAF-induced elastase-dependent neutrophil transendothelial migration is associated with the mobilization of elastase to the neutrophil surface and localization to the migrating front.

7 July 2018

1 reference

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Notch as a mediator of cell fate determination in hematopoiesis: evidence and speculation

7 July 2018

1 reference

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The beta3A subunit gene (Ap3b1) of the AP-3 adaptor complex is altered in the mouse hypopigmentation mutant pearl, a model for Hermansky-Pudlak syndrome and night blindness

7 July 2018

1 reference

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Chp, a homologue of the GTPase Cdc42Hs, activates the JNK pathway and is implicated in reorganizing the actin cytoskeleton

7 July 2018

1 reference

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Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast

7 July 2018

1 reference

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Notch1 and Notch2 inhibit myeloid differentiation in response to different cytokines

7 July 2018

1 reference

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Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions

7 July 2018

1 reference

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Cell surface-bound elastase and cathepsin G on human neutrophils: a novel, non-oxidative mechanism by which neutrophils focus and preserve catalytic activity of serine proteinases

7 July 2018

1 reference

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Elastase-like enzymes in human neutrophils localized by ultrastructural cytochemistry

7 July 2018

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Mutations associated with neutropenia in dogs and humans disrupt intracellular transport of neutrophil elastase.

7 July 2018

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Endocytosis-mediated downregulation of LIN-12/Notch upon Ras activation in Caenorhabditis elegans

27 October 2018

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Notch1 inhibits differentiation of hematopoietic cells by sustaining GATA-2 expression

27 October 2018

1 reference

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Activated Notch2 signaling inhibits differentiation of cerebellar granule neuron precursors by maintaining proliferation.

27 October 2018

1 reference

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Regulation of P-selectin binding to the neutrophil P-selectin counter-receptor P-selectin glycoprotein ligand-1 by neutrophil elastase and cathepsin G.

27 October 2018

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The Notch ligand, Delta-1, inhibits the differentiation of monocytes into macrophages but permits their differentiation into dendritic cells.

27 October 2018

1 reference

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Characterization of mutant neutrophil elastase in severe congenital neutropenia

27 October 2018

1 reference

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Wasp, the Drosophila Wiskott-Aldrich syndrome gene homologue, is required for cell fate decisions mediated by Notch signaling

27 October 2018

1 reference

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Mutations in the gene encoding neutrophil elastase in congenital and cyclic neutropenia

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303357

Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand, Delta-1.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303357

Neutrophil elastase cleavage of human factor IX generates an activated factor IX-like product devoid of coagulant function.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303357

Identification of elastases associated with purified plasma membranes isolated from human monocytes and lymphocytes

27 October 2018

1 reference

12 December 2020

Human coagulation factor V is activated to the functional cofactor by elastase and cathepsin G expressed at the monocyte surface

1 reference

12 December 2020

Mutations in the ELA2 gene encoding neutrophil elastase are present in most patients with sporadic severe congenital neutropenia but only in some patients with the familial form of the disease

1 reference

12 December 2020

Paternal mosaicism proves the pathogenic nature of mutations in neutrophil elastase in severe congenital neutropenia

1 reference

12 December 2020

10.1128/MCB.24.1.58-70.2004

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DOI

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22 December 2019

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22 December 2019

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