Dual inhibition of plasminogen kringle 5 on angiogenesis and chemotaxis suppresses tumor metastasis by targeting HIF-1α pathway (Q34541713)

2 August 2017

Dual inhibition of plasminogen kringle 5 on angiogenesis and chemotaxis suppresses tumor metastasis by targeting HIF-1α pathway (English)

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2 August 2017

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Wei-Bin Cai

1

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2 August 2017

Yang Zhang

2

1 reference

2 August 2017

Rui Cheng

3

1 reference

2 August 2017

Zheng Wang

4

1 reference

2 August 2017

Shu-Huan Fang

5

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2 August 2017

Zu-Min Xu

6

1 reference

2 August 2017

Xia Yang

7

1 reference

2 August 2017

Zhong-Han Yang

8

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2 August 2017

Jian-Xing Ma

9

1 reference

2 August 2017

Chun-Kui Shao

10

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2 August 2017

Guo-Quan Gao

11

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2 August 2017

language of work or name

English

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publication date

31 December 2012

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2 August 2017

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2 August 2017

7

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2 August 2017

12

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2 August 2017

e53152

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Creative Commons Attribution 4.0 International

2 August 2017

start time

31 December 2012

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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High efficacy and minimal peptide required for the anti-angiogenic and anti-hepatocarcinoma activities of plasminogen K5.

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Plasminogen kringle 5 induces apoptosis of brain microvessel endothelial cells: sensitization by radiation and requirement for GRP78 and LRP1.

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Kallikrein-binding protein inhibits growth of gastric carcinoma by reducing vascular endothelial growth factor production and angiogenesis

7 July 2018

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A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development

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Effect of antisense hypoxia-inducible factor 1alpha on progression, metastasis, and chemosensitivity of pancreatic cancer

7 July 2018

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VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

7 July 2018

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Plasminogen kringle 5 inhibits alkali-burn-induced corneal neovascularization

7 July 2018

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Plasminogen kringle 5-engineered glioma cells block migration of tumor-associated macrophages and suppress tumor vascularization and progression

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Kringle 5 of human plasminogen induces apoptosis of endothelial and tumor cells through surface-expressed glucose-regulated protein 78.

7 July 2018

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Ref-1/Ape is critical for formation of the hypoxia-inducible transcriptional complex on the hypoxic response element of the rat pulmonary artery endothelial cell VEGF gene

7 July 2018

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Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.

7 July 2018

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The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis.

7 July 2018

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7 July 2018

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Down-regulation of vascular endothelial growth factor and up-regulation of pigment epithelium-derived factor: a possible mechanism for the anti-angiogenic activity of plasminogen kringle 5

7 July 2018

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7 July 2018

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7 July 2018

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Hypoxia modulated gene expression: angiogenesis, metastasis and therapeutic exploitation

7 July 2018

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Selective inhibition by kringle 5 of human plasminogen on endothelial cell migration, an important process in angiogenesis

7 July 2018

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Kringle 5 of plasminogen is a novel inhibitor of endothelial cell growth

7 July 2018

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Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

7 July 2018

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Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

7 July 2018

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Angiogenesis in cancer, vascular, rheumatoid and other disease

7 July 2018

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Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

7 July 2018

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Vascular endothelial growth factor is a secreted angiogenic mitogen

7 July 2018

1 reference

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Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma

7 July 2018

1 reference

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Enhanced anti-angiogenic effect of a deletion mutant of plasminogen kringle 5 on neovascularization

7 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0053152

Kringle 5 of human plasminogen suppresses hepatocellular carcinoma growth both in grafted and xenografted mice by anti-angiogenic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0053152

Plasminogen kringle 5 reduces vascular leakage in the retina in rat models of oxygen-induced retinopathy and diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0053152

Intravitreal injection of plasminogen kringle 5, an endogenous angiogenic inhibitor, arrests retinal neovascularization in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0053152

Blockade of the Stromal Cell–Derived Factor-1/CXCR4 Axis AttenuatesIn vivoTumor Growth by Inhibiting Angiogenesis in a Vascular Endothelial Growth Factor–Independent Manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0053152

The Voltage-dependent Anion Channel Is a Receptor for Plasminogen Kringle 5 on Human Endothelial Cells

21 January 2018

1 reference

12 December 2020

Induction and nuclear translocation of hypoxia-inducible factor-1 (HIF-1): heterodimerization with ARNT is not necessary for nuclear accumulation of HIF-1alpha

1 reference

12 December 2020

Plasminogen Kringle 5 blocks tumor progression by antiangiogenic and proinflammatory pathways

1 reference

12 December 2020

Combination of human plasminogen kringle 5 with ionizing radiation significantly enhances the efficacy of antitumor effect

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0053152

Identifiers

DOI

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2 August 2017

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2 August 2017

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