Small-molecule therapeutics for the treatment of glycolipid lysosomal storage disorders (Q34534466)

2 August 2017

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title

Small-molecule therapeutics for the treatment of glycolipid lysosomal storage disorders (English)

1 reference

2 August 2017

Keishi Narita

3

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Frances Platt

object named as

Frances M Platt

series ordinal

5

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Raymond Dwek

series ordinal

4

object named as

Raymond A Dwek

1 reference

2 August 2017

1

Terry D Butters

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2 August 2017

2

Howard R Mellor

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2 August 2017

language of work or name

English

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publication date

1 May 2003

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2 August 2017

number of pages

19

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Philosophical Transactions of the Royal Society B

inferred from page(s)

published in

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2 August 2017

volume

358

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2 August 2017

issue

1433

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2 August 2017

page(s)

927-945

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Gaucher disease and the clinical experience with substrate reduction therapy

2 August 2017

cites work

1 reference

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Substrate reduction therapy: clinical evaluation in type 1 Gaucher disease

7 July 2018

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Substrate reduction therapy in mouse models of the glycosphingolipidoses

7 July 2018

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Biosynthesis and degradation of mammalian glycosphingolipids

7 July 2018

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Targeting glycosylation as a therapeutic approach

7 July 2018

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Preparation, biochemical characterization and biological properties of radiolabelled N-alkylated deoxynojirimycins

7 July 2018

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Study of the mechanism of antiviral action of iminosugar derivatives against bovine viral diarrhea virus

7 July 2018

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Polyhydroxylated alkaloids -- natural occurrence and therapeutic applications

7 July 2018

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Substrate reduction therapy for glycosphingolipid storage disorders

7 July 2018

1 reference

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Interaction of membrane proteins and lipids with solubilizing detergents

7 July 2018

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Crystal structure of human GM2-activator protein with a novel beta-cup topology

7 July 2018

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X-ray crystal structure of rabbit N-acetylglucosaminyltransferase I: catalytic mechanism and a new protein superfamily

7 July 2018

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The 1.9 Å crystal structure ofEscherichia coliMurG, a membrane-associated glycosyltransferase involved in peptidoglycan biosynthesis

7 July 2018

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ABC transporters in lipid transport

7 July 2018

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The first structure of UDP-glucose dehydrogenase reveals the catalytic residues necessary for the two-fold oxidation

7 July 2018

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Two possible conducting states of the influenza A virus M2 ion channel

7 July 2018

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Biophysics of ceramide signaling: interaction with proteins and phase transition of membranes

7 July 2018

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Conserved domains of glycosyltransferases

7 July 2018

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Cathepsin D targeted by acid sphingomyelinase-derived ceramide

7 July 2018

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High resolution crystal structures of the Escherichia coli lytic transglycosylase Slt70 and its complex with a peptidoglycan fragment

7 July 2018

1 reference

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A vital role for glycosphingolipid synthesis during development and differentiation

7 July 2018

1 reference

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Crystal structures of the bovine beta 4galactosyltransferase catalytic domain and its complex with uridine diphosphogalactose

7 July 2018

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Histidine-193 of rat glucosylceramide synthase resides in a UDP-glucose- and inhibitor (D-threo-1-phenyl-2-decanoylamino-3-morpholinopropan-1-ol)-binding region: a biochemical and mutational study

7 July 2018

1 reference

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Structure of the nucleotide-diphospho-sugar transferase, SpsA from Bacillus subtilis, in native and nucleotide-complexed forms

7 July 2018

1 reference

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Delayed symptom onset and increased life expectancy in Sandhoff disease mice treated with N-butyldeoxynojirimycin.

7 July 2018

1 reference

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7 July 2018

Membrane protein folding

1 reference

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Differential effects of glycolipid biosynthesis inhibitors on ceramide-induced cell death in neuroblastoma cells

7 July 2018

1 reference

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Prevalence of lysosomal storage disorders

7 July 2018

1 reference

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The M2 channel of influenza A virus: a molecular dynamics study

7 July 2018

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Long-term effectiveness of a new alpha-glucosidase inhibitor (BAY m1099-miglitol) in insulin-treated type 2 diabetes mellitus

7 July 2018

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Activity of the yeast MNN1 alpha-1,3-mannosyltransferase requires a motif conserved in many other families of glycosyltransferases

7 July 2018

1 reference

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Measurement of spontaneous transfer and transbilayer movement of BODIPY-labeled lipids in lipid vesicles.

7 July 2018

1 reference

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Prevention of lysosomal storage in Tay-Sachs mice treated with N-butyldeoxynojirimycin

7 July 2018

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Hepatitis B virus (HBV) envelope glycoproteins vary drastically in their sensitivity to glycan processing: evidence that alteration of a single N-linked glycosylation site can regulate HBV secretion

7 July 2018

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N-butyldeoxynojirimycin-mediated inhibition of human immunodeficiency virus entry correlates with changes in antibody recognition of the V1/V2 region of gp120

7 July 2018

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Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693180

N-butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693180

Crystal structure of the DNA modifying enzyme beta-glucosyltransferase in the presence and absence of the substrate uridine diphosphoglucose

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693180

Introduction of oxygen into the alkyl chain of N-decyl-dNM decreases lipophilicity and results in increased retention of glucose residues on N-linked oligosaccharides

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693180

The safety and efficacy of combination N-butyl-deoxynojirimycin (SC-48334) and zidovudine in patients with HIV-1 infection and 200-500 CD4 cells/mm3.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693180

Isolation, characterization, and expression of cDNA clones that encode rat UDP-galactose: ceramide galactosyltransferase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693180

Sphingolipid metabolism in cultured fibroblasts: microscopic and biochemical studies employing a fluorescent ceramide analogue

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693180

Enzymatic Synthesis of Glucocerebroside by a Glucosyltransferase from Embryonic Chicken Brain

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693180

The antiglycogenolytic action of 1-deoxynojirimycin results from a specific inhibition of the alpha-1,6-glucosidase activity of the debranching enzyme

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693180

Activator proteins and topology of lysosomal sphingolipid catabolism.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693180

Novel oral treatment of Gaucher's disease with N-butyldeoxynojirimycin (OGT 918) to decrease substrate biosynthesis.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693180

Oligomerization and topology of the Golgi membrane protein glucosylceramide synthase

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693180

The GM2 activator protein, its roles as a co-factor in GM2 hydrolysis and as a general glycolipid transport protein.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1693180

Treatment of chronic hepadnavirus infection in a woodchuck animal model with an inhibitor of protein folding and trafficking.

27 October 2018

1 reference

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Inhibition of Glycosphingolipid Biosynthesis: Application to Lysosomal Storage Disorders

27 October 2018

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12 December 2020

Regulation of UDP-glucose:ceramide glucosyltransferase-1 by ceramide

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12 December 2020

N-butyldeoxygalactonojirimycin: a more selective inhibitor of glycosphingolipid biosynthesis than N-butyldeoxynojirimycin, in vitro and in vivo

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12 December 2020

Phase IB clinical trial of the oligosaccharide processing inhibitor swainsonine in patients with advanced malignancies

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12 December 2020

Induction of glucosylceramide synthase by synthase inhibitors and ceramide

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12 December 2020

Imino sugar therapy for type 1 Gaucher disease

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12 December 2020

Identifiers

DOI

10.1098/RSTB.2003.1278

1 reference

2 August 2017

1 reference

2 August 2017

1 reference