Exploring key orientations at protein-protein interfaces with small molecule probes (Q34524107)

2 August 2017

title

Exploring key orientations at protein-protein interfaces with small molecule probes (English)

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2 August 2017

4

Thomas R Ioerger

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2 August 2017

Eunhwa Ko

1

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2 August 2017

Arjun Raghuraman

series ordinal

2

1 reference

2 August 2017

Lisa M Perez

series ordinal

3

1 reference

2 August 2017

Kevin Burgess

series ordinal

5

1 reference

2 August 2017

language of work or name

English

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publication date

27 December 2012

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Journal of the American Chemical Society

2 August 2017

published in

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2 August 2017

volume

135

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2 August 2017

issue

1

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2 August 2017

page(s)

167-173

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Small-molecule stabilization of protein-protein interactions: an underestimated concept in drug discovery?

2 August 2017

cites work

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7 July 2018

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Screening of protein-protein interaction modulators via sulfo-click kinetic target-guided synthesis

7 July 2018

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Minimalist and universal peptidomimetics.

7 July 2018

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Targeting protein-protein interactions for therapeutic intervention: a challenge for the future.

7 July 2018

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Discovery of modulators of protein-protein interactions: current approaches and limitations

7 July 2018

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Tripeptide motifs in biology: targets for peptidomimetic design.

7 July 2018

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Universal peptidomimetics.

7 July 2018

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Toward the first nonpeptidic molecular tong inhibitor of wild-type and mutated HIV-1 protease dimerization

7 July 2018

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Cross-linked peptoid-based dimerization inhibitors of HIV-1 protease

7 July 2018

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Neuronal caspase-3 signaling: not only cell death

7 July 2018

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Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

7 July 2018

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Dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes: focus on sitagliptin

7 July 2018

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Modulation of protein-protein interactions by stabilizing/mimicking protein secondary structure elements

7 July 2018

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Inhibition of HIV-1 replication by a peptide dimerization inhibitor of HIV-1 protease.

7 July 2018

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Recent developments in focused library design: targeting gene-families

7 July 2018

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Glyceraldehyde-3-phosphate dehydrogenase, apoptosis, and neurodegenerative diseases

7 July 2018

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DNA-templated organic synthesis and selection of a library of macrocycles

7 July 2018

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Fragment-based lead discovery

7 July 2018

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Effect of detergent on "promiscuous" inhibitors

7 July 2018

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Kinase inhibitors: not just for kinases anymore

7 July 2018

1 reference

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A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

7 July 2018

1 reference

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Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis

7 July 2018

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Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis

7 July 2018

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Site-directed ligand discovery

7 July 2018

1 reference

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Small-Molecule Inhibitors of HIV-1 Protease Dimerization Derived from Cross-Linked Interfacial Peptides This work was supported by NIH (GM52739) and NSF (9457372-CHE).

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3551583

Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease.

7 July 2018

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The atomic structure of protein-protein recognition sites

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3551583

Triterpenes as potential dimerization inhibitors of HIV-1 protease

7 July 2018

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Novel fluorogenic substrates for assaying retroviral proteases by resonance energy transfer

7 July 2018

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Dimer disruption and monomer sequestration by alkyl tripeptides are successful strategies for inhibiting wild-type and multidrug-resistant mutated HIV-1 proteases

7 July 2018

1 reference

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Virtual hydrocarbon and combinatorial databases for use with CAVEAT.

27 October 2018

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Dimerization inhibitors of HIV-1 protease based on a bicyclic guanidinium subunit

27 October 2018

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Regulation of HIV-1 protease activity through cysteine modification.

27 October 2018

1 reference

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CAVEAT: a program to facilitate the design of organic molecules

27 October 2018

1 reference

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Sidechain-linked inhibitors of HIV-1 protease dimerization.

27 October 2018

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12 December 2020

Dissociative inhibition of dimeric enzymes. Kinetic characterization of the inhibition of HIV-1 protease by its COOH-terminal tetrapeptide

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12 December 2020

The structural stability of the HIV-1 protease

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12 December 2020

Quenched molecular dynamics simulations of tuftsin and proposed cyclic analogues

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12 December 2020

A convenient method for determining cyclic peptide conformation from 1D 1H-NMR information

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12 December 2020

Identifiers

DOI

10.1021/JA3067258

1 reference

2 August 2017

1 reference

2 August 2017

1 reference