Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy. (Q34492438)

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English	Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy.	scientific article

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23 February 2020

Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy (English)

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23 February 2020

muscle weakness

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David Meyerholz

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23 February 2020

Christopher M Adams

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23 February 2020

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Scott M Ebert

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23 February 2020

Michael C Dyle

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23 February 2020

Steven A Bullard

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23 February 2020

Jason M Dierdorff

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Daryl J Murry

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23 February 2020

Daniel K Fox

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23 February 2020

Kale S Bongers

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23 February 2020

Vitor A Lira

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23 February 2020

John J Talley

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23 February 2020

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3 September 2015

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23 February 2020

number of pages

15

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Journal of Biological Chemistry

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23 February 2020

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23 February 2020

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23 February 2020

25497-25511

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23 February 2020

describes a project that uses

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AMPK activation of muscle autophagy prevents fasting-induced hypoglycemia and myopathy during aging

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6 July 2018

Use of mRNA expression signatures to discover small molecule inhibitors of skeletal muscle atrophy

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6 July 2018

p53 and ATF4 mediate distinct and additive pathways to skeletal muscle atrophy during limb immobilization

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Systems-based discovery of tomatidine as a natural small molecule inhibitor of skeletal muscle atrophy

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Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models

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Anticarcinogenic, cardioprotective, and other health benefits of tomato compounds lycopene, α-tomatine, and tomatidine in pure form and in fresh and processed tomatoes

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Skeletal muscle denervation causes skeletal muscle atrophy through a pathway that involves both Gadd45a and HDAC4.

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Thigh muscle volume in relation to age, sex and femur volume.

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Exercise and nutrition to target protein synthesis impairments in aging skeletal muscle.

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6 July 2018

Rapamycin extends murine lifespan but has limited effects on aging

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Regulation of muscle protein synthesis and the effects of catabolic states

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ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death.

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6 July 2018

Sustained activation of mTORC1 in skeletal muscle inhibits constitutive and starvation-induced autophagy and causes a severe, late-onset myopathy

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6 July 2018

Genomic and proteomic profiling reveals reduced mitochondrial function and disruption of the neuromuscular junction driving rat sarcopenia

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Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease

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Stress-induced skeletal muscle Gadd45a expression reprograms myonuclei and causes muscle atrophy.

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mRNA expression signatures of human skeletal muscle atrophy identify a natural compound that increases muscle mass

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Activating transcription factor 4.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4646196

6 July 2018

Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program

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Gene expression profile of aging in human muscle

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Identification of ubiquitin ligases required for skeletal muscle atrophy

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Gene expression profile of aging and its retardation by caloric restriction

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The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study.

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Disruption of DAG1 in differentiated skeletal muscle reveals a role for dystroglycan in muscle regeneration.

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A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance

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Identifiers

10.1074/JBC.M115.681445

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23 February 2020

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23 February 2020

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