Role of heparan sulfate in fibroblast growth factor signalling: a structural view (Q34489556)

2 August 2017

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title

Role of heparan sulfate in fibroblast growth factor signalling: a structural view (English)

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2 August 2017

Pellegrini L

1

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2 August 2017

1 October 2001

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Current Opinion in Structural Biology

2 August 2017

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2 August 2017

11

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2 August 2017

5

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2 August 2017

629-634

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FGFs, heparan sulfate and FGFRs: complex interactions essential for development

2 August 2017

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https://api.crossref.org/works/10.1016%2FS0959-440X%2800%2900258-X

7 January 2021

Three-Dimensional Structures of Acidic and Basic Fibroblast Growth Factors

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https://api.crossref.org/works/10.1016%2FS0959-440X%2800%2900258-X

7 January 2021

Heparin structure and interactions with basic fibroblast growth factor

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https://api.crossref.org/works/10.1016%2FS0959-440X%2800%2900258-X

7 January 2021

Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization

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https://api.crossref.org/works/10.1016%2FS0959-440X%2800%2900258-X

7 January 2021

Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin

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https://api.crossref.org/works/10.1016%2FS0959-440X%2800%2900258-X

7 January 2021

Structural basis for FGF receptor dimerization and activation

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https://api.crossref.org/works/10.1016%2FS0959-440X%2800%2900258-X

7 January 2021

Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2800%2900258-X

7 January 2021

Properly oriented heparin-decasaccharide-induced dimers are the biologically active form of basic fibroblast growth factor.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2800%2900258-X

7 January 2021

Regulation of FGF-1 mitogenic activity by heparan sulfate oligosaccharides is dependent on specific structural features: differential requirements for the modulation of FGF-1 and FGF-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2800%2900258-X

7 January 2021

Selectively desulfated heparin inhibits fibroblast growth factor-induced mitogenicity and angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2800%2900258-X

7 January 2021

Energetic characterization of the basic fibroblast growth factor-heparin interaction: identification of the heparin binding domain

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2800%2900258-X

7 January 2021

An essential heparin-binding domain in the fibroblast growth factor receptor kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2800%2900258-X

7 January 2021

Structure of a heparin-linked biologically active dimer of fibroblast growth factor

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2800%2900258-X

7 January 2021

Effect of heparin on the binding affinity of acidic FGF for the cloned human FGF receptors, flg and bek

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2800%2900258-X

7 January 2021

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2800%2900258-X

7 January 2021

Multivalent ligand-receptor binding interactions in the fibroblast growth factor system produce a cooperative growth factor and heparin mechanism for receptor dimerization

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2800%2900258-X

7 January 2021

Structural interactions of fibroblast growth factor receptor with its ligands

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2800%2900258-X

7 January 2021

Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2800%2900258-X

7 January 2021

Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2800%2900258-X

7 January 2021

Heparin-derived oligosaccharides: affinity for acidic fibroblast growth factor and effect on its growth-promoting activity for human endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2800%2900258-X

7 January 2021

Structural requirements in heparin for binding and activation of FGF-1 and FGF-4 are different from that for FGF-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2800%2900258-X

7 January 2021

Heparan sulfate oligosaccharides require 6-O-sulfation for promotion of basic fibroblast growth factor mitogenic activity

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2800%2900258-X

7 January 2021

Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2800%2900258-X

7 January 2021

Monomer complexes of basic fibroblast growth factor and heparan sulfate oligosaccharides are the minimal functional unit for cell activation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2800%2900258-X

7 January 2021

Distinct role of 2-O-, N-, and 6-O-sulfate groups of heparin in the formation of the ternary complex with basic fibroblast growth factor and soluble FGF receptor-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2800%2900258-X

7 January 2021

Importance of 2-O-sulfate groups of uronate residues in heparin for activation of FGF-1 and FGF-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2800%2900258-X

7 January 2021

Characterization of fibroblast growth factor 1 binding heparan sulfate domain

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https://api.crossref.org/works/10.1016%2FS0959-440X%2800%2900258-X

7 January 2021

Sequence analysis of heparan sulfate epitopes with graded affinities for fibroblast growth factors 1 and 2.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2800%2900258-X

7 January 2021

Fibroblast growth factor receptor signalling is dictated by specific heparan sulphate saccharides

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2800%2900258-X

7 January 2021

10.1016/S0959-440X(00)00258-X

Identifiers

DOI

1 reference

2 August 2017

1 reference

PubMed ID

11785766