A double-blind, placebo-controlled intervention trial of 3 and 10 mg sublingual melatonin for post-concussion syndrome in youths (PLAYGAME): study protocol for a randomized controlled trial (Q34486287)

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scientific article published on 7 July 2014

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English	A double-blind, placebo-controlled intervention trial of 3 and 10 mg sublingual melatonin for post-concussion syndrome in youths (PLAYGAME): study protocol for a randomized controlled trial	scientific article published on 7 July 2014

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scholarly article

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2 August 2017

A double-blind, placebo-controlled intervention trial of 3 and 10 mg sublingual melatonin for post-concussion syndrome in youths (PLAYGAME): study protocol for a randomized controlled trial (English)

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Europe PubMed Central

2 August 2017

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based on heuristic

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post-concussion syndrome

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based on heuristic

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based on heuristic

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Karen Maria Barlow

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Frank P MacMaster

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Michael D. Hill

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Lawrence Richer

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Robert W. Platt

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Alberto Nettel-Aguirre

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Alberto Nettel-Aguirre

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Carolyn A Emery

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Carolyn A Emery

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Brian L Brooks

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Adam Kirton

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Trevor Seeger

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Michael Esser

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Susan Crawford

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Roger Zemek

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Mikrogianakis Angelo

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Valerie Kirk

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David Johnson

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Jeff Buchhalter

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Brenda Turley

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Jamie Hutchison

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publication date

7 July 2014

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11 June 2020

https://scigraph.springernature.com/pub.10.1186/1745-6215-15-271

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Rehabilitation of children with traumatic brain injury: a critical review

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6 July 2018

Characteristics of post-traumatic headaches in children following mild traumatic brain injury and their response to treatment: a prospective cohort

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6 July 2018

Summary of evidence-based guideline update: evaluation and management of concussion in sports: report of the Guideline Development Subcommittee of the American Academy of Neurology

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6 July 2018

The effects of rest and treatment following sport-related concussion: a systematic review of the literature

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6 July 2018

Melatonin and mitochondrial dysfunction in the central nervous system

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6 July 2018

Systematic review of interventions for post-traumatic headache

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6 July 2018

The role of free radicals in traumatic brain injury

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6 July 2018

New perspectives in melatonin uses

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6 July 2018

Effect of snowboard-related concussion safety education for recognizing possible concussions.

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6 July 2018

The pathophysiology of concussions in youth

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6 July 2018

Do postconcussive symptoms discriminate injury severity in pediatric mild traumatic brain injury?

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6 July 2018

Analgesic effects of melatonin: a review of current evidence from experimental and clinical studies.

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6 July 2018

Treatment outcomes of chronic post-traumatic headaches after mild head trauma in US soldiers: an observational study

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Antiinflammatory activity of melatonin in central nervous system

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Concussive brain trauma in the mouse results in acute cognitive deficits and sustained impairment of axonal function

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Melatonin-mitochondria interplay in health and disease.

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Melatonin combats molecular terrorism at the mitochondrial level

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Implications of melatonin therapy in irritable bowel syndrome: a systematic review

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Long-term neurocognitive dysfunction in sports: what is the evidence?

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Prophylaxis of migraine with melatonin: a randomized controlled trial.

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Brain functions after sports-related concussion: insights from event-related potentials and functional MRI.

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Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice

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Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.

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Psychological approaches to treatment of postconcussion syndrome: a systematic review

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Melatonin: pharmacological aspects and clinical trends.

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Dose finding of melatonin for chronic idiopathic childhood sleep onset insomnia: an RCT.

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Vestibular rehabilitation for dizziness and balance disorders after concussion.

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Melatonin: a multitasking molecule

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Construct and criterion validity of the Behaviour Rating Inventory of Executive Function (BRIEF) in children referred for neuropsychological assessment after paediatric traumatic brain injury

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Therapeutic potential of melatonin in traumatic central nervous system injury

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Consensus Statement on Concussion in Sport: the 3rd International Conference on Concussion in Sport held in Zurich, November 2008.

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Longitudinal trajectories of postconcussive symptoms in children with mild traumatic brain injuries and their relationship to acute clinical status.

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Dimensions of postconcussive symptoms in children with mild traumatic brain injuries

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Multifocal white matter ultrastructural abnormalities in mild traumatic brain injury with cognitive disability: a voxel-wise analysis of diffusion tensor imaging

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Moderate and severe traumatic brain injury in adults.

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Family burden and parental distress following mild traumatic brain injury in children and its relationship to post-concussive symptoms.

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Pharmacological enhancement of cognitive and behavioral deficits after traumatic brain injury

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In vivo imaging of rapid deformation and strain in an animal model of traumatic brain injury

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Melatonin mitigates mitochondrial malfunction

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Mitochondrial regulation by melatonin and its metabolites.

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Melatonin and mitochondrial function

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Regulation of antioxidant enzymes: a significant role for melatonin

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The Neurometabolic Cascade of Concussion

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The chemistry of melatonin's interaction with reactive species

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Impact of early intervention on outcome following mild head injury in adults

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Effect of melatonin on cerebral edema in rats

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Circadian rhythms and circadian rhythm disorders in children and adolescents

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Significance of melatonin in antioxidative defense system: reactions and products

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Disability in young people and adults one year after head injury: prospective cohort study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227124

6 July 2018

Routine follow up after head injury: a second randomised controlled trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227124

6 July 2018

Convergent and criterion-related validity of the Behavior Assessment System for Children-Parent Rating Scale.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227124

6 July 2018

Does routine follow up after head injury help? A randomised controlled trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227124

6 July 2018

Cell protective role of melatonin in the brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227124

6 July 2018

Reentrainment of Rat Circadian Activity Rhythms: Effects of Melatonin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227124

6 July 2018

Antidepressants not effective in headache associated with minor closed head injury.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227124

6 July 2018

Vertebrate circadian and photoperiodic systems: role of the pineal gland and melatonin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227124

6 July 2018

The Children's Orientation and Amnesia Test: relationship to severity of acute head injury and to recovery of memory.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227124

6 July 2018

The incidence of traumatic brain injury among children in the United States: differences by race

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Exploring children's self-efficacy related to physical activity performance after a mild traumatic brain injury.

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Epidemiology of postconcussion syndrome in pediatric mild traumatic brain injury

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Quality of life and post-concussion symptoms in adults after mild traumatic brain injury: a population-based study in western Sweden.

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Long-term outcomes after uncomplicated mild traumatic brain injury: a comparison with trauma controls.

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Differential recovery of behavioral status and brain function assessed with functional magnetic resonance imaging after mild traumatic brain injury in the rat.

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Neurometabolic changes in the acute phase after sports concussions correlate with symptom severity

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Chronic failure in the maintenance of long-term potentiation following fluid percussion injury in the rat.

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Impaired expression of long-term potentiation in hippocampal slices 4 and 48 h following mild fluid-percussion brain injury in vivo.

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Assessment of metabolic brain damage and recovery following mild traumatic brain injury: a multicentre, proton magnetic resonance spectroscopic study in concussed patients

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Distinct time courses of secondary brain damage in the hippocampus following brain concussion and contusion in rats.

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

A survey of treatments for post-concussion syndrome.

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

A preliminary study of subsymptom threshold exercise training for refractory post-concussion syndrome

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Effects of methylphenidate on attentional function after traumatic brain injury. A randomized, placebo-controlled trial.

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Subacute methylphenidate treatment for moderate to moderately severe traumatic brain injury: a preliminary double-blind placebo-controlled study.

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Glutamate induces oxidative stress not mediated by glutamate receptors or cystine transporters: protective effect of melatonin and other antioxidants

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Melatonin attenuates the development of antinociceptive tolerance to delta-, but not to mu-opioid receptor agonist in mice

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Effect of melatonin on intracranial pressure and brain edema following traumatic brain injury: role of oxidative stresses.

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Free-running activity rhythms in the rat: entrainment by melatonin

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Interactions of melatonin and its metabolites with the ABTS cation radical: extension of the radical scavenger cascade and formation of a novel class of oxidation products, C2-substituted 3-indolinones.

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Melatonin increases gene expression for antioxidant enzymes in rat brain cortex.

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Combination therapy with melatonin and dexamethasone in a mouse model of traumatic brain injury.

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Neuroprotection against Abeta and glutamate toxicity by melatonin: are GABA receptors involved?

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Taurine prevents the neurotoxicity of beta-amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Melatonin: Quantum-chemical and biochemical investigation of antioxidant activity

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Protective effect of melatonin against head trauma-induced hippocampal damage and spatial memory deficits in immature rats

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Examining the relation between combat-related concussion, a novel 5-factor model of posttraumatic stress symptoms, and health-related quality of life in Iraq and Afghanistan veterans

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Possible involvement of GABAergic mechanism in protective effect of melatonin against sleep deprivation-induced behaviour modification and oxidative damage in mice

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Melatonin for treatment of sleep disorders in children with developmental disabilities.

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Melatonin, 3 mg, is effective for migraine prevention

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Melatonin to prevent migraine or tension-type headache in children

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

The effect of melatonin in patients with fibromyalgia: a pilot study.

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Protective effect of melatonin in a chronic experimental model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Health-related quality of life and psychosocial consequences after mild traumatic brain injury in children and adolescents.

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

The Pediatric Quality of Life Inventory: an evaluation of its reliability and validity for children with traumatic brain injury.

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Computerized neuropsychological testing to rapidly evaluate cognition in pediatric patients with neurologic disorders.

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Circadian rhythm sleep disorders following mild traumatic brain injury

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Oculomotor neurorehabilitation for reading in mild traumatic brain injury (mTBI): an integrative approach.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227124

27 October 2018

The effect of repetitious concussions on cognitive functions in rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227124

27 October 2018

Pathophysiological response to experimental diffuse brain trauma differs as a function of developmental age.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227124

27 October 2018

Melatonin attenuates radiation-induced learning deficit and brain oxidative stress in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227124

27 October 2018

Effect of melatonin on brain oxidative damage induced by traumatic brain injury in immature rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227124

27 October 2018

Melatonin-induced neuroprotection after closed head injury is associated with increased brain antioxidants and attenuated late-phase activation of NF-kappaB and AP-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227124

27 October 2018

Melatonin supplementation ameliorates oxidative stress and inflammatory signaling induced by strenuous exercise in adult human males

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Prevalence of traumatic brain injury among children, adolescents and young adults: Prospective evidence from a birth cohort

1 reference

https://api.crossref.org/works/10.1186%2F1745-6215-15-271

21 January 2018

Melatonin attenuates brain contusion-induced oxidative insult, inactivation of signal transducers and activators of transcription 1, and upregulation of suppressor of cytokine signaling-3 in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/25001947

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Anxiolytical, analgesic and sedative effects of melatonin in the perioperative phase]

1 reference

https://pubmed.ncbi.nlm.nih.gov/25001947

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cervicogenic headache: a real headache

1 reference

https://pubmed.ncbi.nlm.nih.gov/25001947

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Melatonin administrated immediately before an intense exercise reverses oxidative stress, improves immunological defenses and lipid metabolism in football players

1 reference

https://pubmed.ncbi.nlm.nih.gov/25001947

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of post-traumatic headache with amitriptyline

1 reference

https://pubmed.ncbi.nlm.nih.gov/25001947

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Melatonin reduces ischemia/reperfusion-induced superoxide generation in arterial wall and cell death in skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/25001947

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A preliminary study of melatonin in irritable bowel syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/25001947

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glial cell survival is enhanced during melatonin-induced neuroprotection against cerebral ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/25001947

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical significance: A statistical approach to defining meaningful change in psychotherapy research

1 reference

https://pubmed.ncbi.nlm.nih.gov/25001947

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1745-6215-15-271

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25001947%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Dimensions Publication ID

0 references

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25001947%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25001947%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

ResearchGate publication ID

0 references

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