Function and dysfunction of two-pore channels (Q34483905)

2 August 2017

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title

Function and dysfunction of two-pore channels (English)

1 reference

2 August 2017

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26152696%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

author name string

Sandip Patel

series ordinal

1

1 reference

2 August 2017

7 July 2015

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2 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26152696%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

volume

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26152696%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

page(s)

re7

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26152696%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

issue

384

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26152696%20AND%20SRC:MED&resulttype=core&format=json

The VGL-Chanome: A Protein Superfamily Specialized for Electrical Signaling and Ionic Homeostasis

14 June 2020

cites work

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Molecular cloning of a novel form (two-repeat) protein related to voltage-gated sodium and calcium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

A putative two pore channel AtTPC1 mediates Ca(2+) flux in Arabidopsis leaf cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Overview of molecular relationships in the voltage-gated ion channel superfamily.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Domain assembly of NAADP-gated two-pore channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Two-pore channels form homo- and heterodimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Membrane topology of NAADP-sensitive two-pore channels and their regulation by N-linked glycosylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Two-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

An ancestral deuterostome family of two-pore channels mediates nicotinic acid adenine dinucleotide phosphate-dependent calcium release from acidic organelles

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

NAADP mobilizes calcium from acidic organelles through two-pore channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

The two-pore channel TPCN2 mediates NAADP-dependent Ca(2+)-release from lysosomal stores

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

The vacuolar Ca2+-activated channel TPC1 regulates germination and stomatal movement.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

An N-terminal dileucine motif directs two-pore channels to the tonoplast of plant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Acidic calcium stores open for business: expanding the potential for intracellular Ca2+ signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Evolution of acidic Ca²⁺ stores and their resident Ca²⁺-permeable channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated calcium signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Coordination of Ca2+ signalling by NAADP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

NAADP: a universal Ca2+ trigger

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

A primer of NAADP-mediated Ca(2+) signalling: From sea urchin eggs to mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

A derivative of NADP mobilizes calcium stores insensitive to inositol trisphosphate and cyclic ADP-ribose

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

NAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggs

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Direct mobilisation of lysosomal Ca2+ triggers complex Ca2+ signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

A computational model of lysosome-ER Ca2+ microdomains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

The NAADP receptor: new receptors or new regulation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Linking NAADP to ion channel activity: a unifying hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Cyclic adenosine diphosphate ribose activates ryanodine receptors, whereas NAADP activates two-pore domain channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Organelle-specific subunit interactions of the vertebrate two-pore channel family

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

TPC2 proteins mediate nicotinic acid adenine dinucleotide phosphate (NAADP)- and agonist-evoked contractions of smooth muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Characterization of two-pore channel 2 (TPCN2)-mediated Ca2+ currents in isolated lysosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Membrane potential regulates nicotinic acid adenine dinucleotide phosphate (NAADP) dependence of the pH- and Ca2+-sensitive organellar two-pore channel TPC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Reconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

NAADP induces pH changes in the lumen of acidic Ca2+ stores

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Nicotinic acid adenine dinucleotide phosphate (NAADP) regulates autophagy in cultured astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Acidic NAADP-releasable Ca(2+) compartments in the megakaryoblastic cell line MEG01.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Two pore channel 2 differentially modulates neural differentiation of mouse embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Two pore channel 2 (TPC2) inhibits autophagosomal-lysosomal fusion by alkalinizing lysosomal pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

NAADP-sensitive two-pore channels are present and functional in gastric smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

The voltage-gated sodium channel TPC1 confers endolysosomal excitability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

A non-inactivating high-voltage-activated two-pore Na⁺ channel that supports ultra-long action potentials and membrane bistability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

The phosphoinositide PI(3,5)P₂ mediates activation of mammalian but not plant TPC proteins: functional expression of endolysosomal channels in yeast and plant cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Convergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Reconstitution and characterization of a nicotinic acid adenine dinucleotide phosphate (NAADP)-sensitive Ca2+ release channel from liver lysosomes of rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

The N-terminal region of two-pore channel 1 regulates trafficking and activation by NAADP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

TPC1 has two variant isoforms, and their removal has different effects on endo-lysosomal functions compared to loss of TPC2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

TPC1 Knockout Knocks Out TPC1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Photoaffinity labeling of nicotinic acid adenine dinucleotide phosphate (NAADP) targets in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Photoaffinity labeling of high affinity nicotinic acid adenine dinucleotide phosphate (NAADP)-binding proteins in sea urchin egg

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Nicotinic Acid Adenine Dinucleotide 2'-Phosphate (NAADP) Binding Proteins in T-Lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Messenger-specific role for nicotinic acid adenine dinucleotide phosphate in neuronal differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Nicotinic acid adenine dinucleotide phosphate mediates Ca2+ signals and contraction in arterial smooth muscle via a two-pool mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Acidic NAADP-sensitive calcium stores in the endothelium: agonist-specific recruitment and role in regulating blood pressure

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Nicotinic acid adenine dinucleotide phosphate regulates skeletal muscle differentiation via action at two-pore channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Identification of two-pore channel 2 as a novel regulator of osteoclastogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

NAADP links histamine H1 receptors to secretion of von Willebrand factor in human endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Lysosomal two-pore channel subtype 2 (TPC2) regulates skeletal muscle autophagic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Two-pore channels function in calcium regulation in sea star oocytes and embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Two-pore channel 1 interacts with citron kinase, regulating completion of cytokinesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Lysosomal impairment in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Lysosome-dependent pathways as a unifying theme in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Two-pore channels at the intersection of endolysosomal membrane traffic

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

siRNA screen for genes that affect Junín virus entry uncovers voltage-gated calcium channels as a therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

The α2δ subunits of voltage-gated calcium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

The role of calcium and other ions in sorting and delivery in the late endocytic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Regulation of membrane trafficking by signalling on endosomal and lysosomal membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Presenilin-null cells have altered two-pore calcium channel expression and lysosomal calcium: implications for lysosomal function

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Identification of a novel gene for diabetic traits in rats, mice, and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

Absence of intracellular ion channels TPC1 and TPC2 leads to mature-onset obesity in male mice, due to impaired lipid availability for thermogenesis in brown adipose tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB3314

10.1126/SCISIGNAL.AAB3314

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26152696%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

1 reference