The Arctic AβPP mutation leads to Alzheimer's disease pathology with highly variable topographic deposition of differentially truncated Aβ (Q34481815)

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English	The Arctic AβPP mutation leads to Alzheimer's disease pathology with highly variable topographic deposition of differentially truncated Aβ	scientific article

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1 March 2020

The Arctic AβPP mutation leads to Alzheimer's disease pathology with highly variable topographic deposition of differentially truncated Aβ (English)

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Alzheimer's disease

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Maciej Lalowski

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Martin Ingelsson

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Martin Ingelsson

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Lars Lannfelt

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Hannu Kalimo

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Nenad Bogdanovic

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Ola Philipson

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Thomas D Bird

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David Nochlin

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Gerard D Schellenberg

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Rosemarie Brundin

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Tommie Olofsson

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1 March 2020

Rabah Soliymani

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Thomas A Bayer

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Hans Basun

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publication date

10 September 2013

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1 March 2020

Acta Neuropathologica Communications

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1

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1 March 2020

https://scigraph.springernature.com/pub.10.1186/2051-5960-1-60

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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

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Aggregation and fibril morphology of the Arctic mutation of Alzheimer's Aβ peptide by CD, TEM, STEM and in situ AFM

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6 July 2018

Amyloid-beta protofibril levels correlate with spatial learning in Arctic Alzheimer's disease transgenic mice

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Clinical and neuropathological features of the arctic APP gene mutation causing early-onset Alzheimer disease

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6 July 2018

The Arctic Alzheimer mutation favors intracellular amyloid-beta production by making amyloid precursor protein less available to alpha-secretase

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Amino-terminally truncated Abeta peptide species are the main component of cotton wool plaques

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A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide--the first step of a fatal cascade

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Mixtures of wild-type and a pathogenic (E22G) form of Abeta40 in vitro accumulate protofibrils, including amyloid pores.

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6 July 2018

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

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6 July 2018

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21 January 2018

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Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation

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21 January 2018

Abeta protofibrils possess a stable core structure resistant to hydrogen exchange

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21 January 2018

The Arctic amyloid-β precursor protein (AβPP) mutation results in distinct plaques and accumulation of N- and C-truncated Aβ.

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27 October 2018

Immunohistochemical visualization of amyloid-beta protein precursor and amyloid-beta in extra- and intracellular compartments in the human brain

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27 October 2018

Variant Alzheimer disease with spastic paraparesis: neuropathological phenotype

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27 October 2018

Substitutions at codon 22 of Alzheimer's abeta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells.

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27 October 2018

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10.1186/2051-5960-1-60

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