WWOX, the common fragile site FRA16D gene product, regulates ATM activation and the DNA damage response (Q34480661)

2 August 2017

WWOX, the common fragile site FRA16D gene product, regulates ATM activation and the DNA damage response (English)

1 reference

2 August 2017

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Mohammad Abu-Odeh

1

1 reference

2 August 2017

Zaidoun Salah

2

1 reference

2 August 2017

Christoph Herbel

3

1 reference

2 August 2017

Thomas G Hofmann

4

1 reference

2 August 2017

Rami I Aqeilan

5

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2 August 2017

language of work or name

English

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publication date

20 October 2014

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Proceedings of the National Academy of Sciences of the United States of America

2 August 2017

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2 August 2017

111

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2 August 2017

44

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2 August 2017

E4716-25

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describes a project that uses

2 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4226089/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Tumor suppressor WWOX regulates glucose metabolism via HIF1α modulation.

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Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks

6 July 2018

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Fhit deficiency-induced global genome instability promotes mutation and clonal expansion

6 July 2018

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Common chromosome fragile sites in human and murine epithelial cells and FHIT/FRA3B loss-induced global genome instability

6 July 2018

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Common fragile site profiling in epithelial and erythroid cells reveals that most recurrent cancer deletions lie in fragile sites hosting large genes.

6 July 2018

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Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair

6 July 2018

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The ATM protein kinase: regulating the cellular response to genotoxic stress, and more

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ATM kinase activity modulates ITCH E3-ubiquitin ligase activity.

6 July 2018

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Initiation of genome instability and preneoplastic processes through loss of Fhit expression

6 July 2018

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The complex basis underlying common fragile site instability in cancer

6 July 2018

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WW domain-containing proteins: retrospectives and the future.

6 July 2018

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Common fragile sites: mechanisms of instability revisited.

6 July 2018

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Molecular profiling of common fragile sites in human fibroblasts.

6 July 2018

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Studies of genomic copy number changes in human cancers reveal signatures of DNA replication stress

6 July 2018

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Wwox inactivation enhances mammary tumorigenesis

6 July 2018

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Negative regulation of the Hippo pathway by E3 ubiquitin ligase ITCH is sufficient to promote tumorigenicity

6 July 2018

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Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal

6 July 2018

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Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression

6 July 2018

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Genomic instability--an evolving hallmark of cancer

6 July 2018

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The landscape of somatic copy-number alteration across human cancers

6 July 2018

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Signatures of mutation and selection in the cancer genome

6 July 2018

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WWOX gene and gene product: tumor suppression through specific protein interactions

6 July 2018

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WWOX: its genomics, partners, and functions

6 July 2018

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Nonproteolytic functions of ubiquitin in cell signaling

6 July 2018

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Targeted ablation of the WW domain-containing oxidoreductase tumor suppressor leads to impaired steroidogenesis

6 July 2018

1 reference

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Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice

6 July 2018

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Gamma-H2AX - a novel biomarker for DNA double-strand breaks.

6 July 2018

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Itch: a HECT-type E3 ligase regulating immunity, skin and cancer

6 July 2018

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An oncogene-induced DNA damage model for cancer development

6 July 2018

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Oncogene-induced replication stress preferentially targets common fragile sites in preneoplastic lesions. A genome-wide study

6 July 2018

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The DNA damage response: ten years after

6 July 2018

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6 July 2018

Chromosome fragile sites

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Targeted deletion of Wwox reveals a tumor suppressor function

6 July 2018

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DNA damage checkpoints: from initiation to recovery or adaptation

6 July 2018

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The E3 ubiquitin ligase Itch controls the protein stability of p63

6 July 2018

1 reference

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Cellular responses to DNA damage: one signal, multiple choices

6 July 2018

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Assaying double-strand break repair pathway choice in mammalian cells using a targeted endonuclease or the RAG recombinase

6 July 2018

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gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes

6 July 2018

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WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226089

Expression of common chromosomal fragile site genes, WWOX/FRA16D and FHIT/FRA3B is downregulated by exposure to environmental carcinogens, UV, and BPDE but not by IR.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226089

WOX1 is essential for UVB irradiation-induced apoptosis and down-regulated via translational blockade in UVB-induced cutaneous squamous cell carcinoma in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226089

WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226089

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226089

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226089

Components of DNA damage checkpoint pathway regulate UV exposure-dependent alterations of gene expression of FHIT and WWOX at chromosome fragile sites.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226089

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226089

Frequent loss of WWOX expression in breast cancer: correlation with estrogen receptor status

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226089

The ubiquitin-protein ligase Itch regulates p73 stability

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226089

Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226089

Initiating cellular stress responses

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226089

Functional association between Wwox tumor suppressor protein and p73, a p53 homolog

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226089

WWOX: a candidate tumor suppressor gene involved in multiple tumor types

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226089

ATM and ATR: networking cellular responses to DNA damage

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226089

Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226089

WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226089

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226089

6 July 2018

Common fragile sites.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1409252111

Inactivation of the Wwox gene accelerates forestomach tumor progression in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1409252111

FRA3B and other common fragile sites: the weakest links

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1409252111

Concordant loss of fragile gene expression early in breast cancer development

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1409252111

WW domain-containing oxidoreductase: a candidate tumor suppressor

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25331887

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1409252111

1 reference

2 August 2017

0 references

1 reference

2 August 2017

1 reference