Widespread Proteome Remodeling and Aggregation in Aging C. elegans (Q34475749)

2 August 2017

Widespread Proteome Remodeling and Aggregation in Aging C. elegans (English)

1 reference

Stress-induced protein 1 CELE_F43D9.4

2 August 2017

Caenorhabditis elegans

0 references

1 reference

GOA release 2020-03-11

11

F Ulrich Hartl

1 reference

2 August 2017

8

Christopher M Dobson

1 reference

2 August 2017

9

Michele Vendruscolo

1 reference

2 August 2017

Dirk M Walther

1

1 reference

2 August 2017

Prasad Kasturi

2

1 reference

2 August 2017

Min Zheng

3

1 reference

2 August 2017

Stefan Pinkert

4

1 reference

2 August 2017

Giulia Vecchi

5

1 reference

2 August 2017

Prajwal Ciryam

6

1 reference

2 August 2017

Richard I Morimoto

7

1 reference

2 August 2017

Matthias Mann

10

1 reference

2 August 2017

language of work or name

English

0 references

publication date

1 May 2015

1 reference

2 August 2017

1 reference

2 August 2017

161

1 reference

2 August 2017

919-932

1 reference

2 August 2017

4

1 reference

A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease

2 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

HSF1 deficiency and impaired HSP90-dependent protein folding are hallmarks of aneuploid human cells.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Organismal proteostasis: role of cell-nonautonomous regulation and transcellular chaperone signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Proteostasis impairment in protein-misfolding and -aggregation diseases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

The amyloid state and its association with protein misfolding diseases.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Quantifying absolute protein synthesis rates reveals principles underlying allocation of cellular resources

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Enhancing protein disaggregation restores proteasome activity in aged cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

A cytoprotective perspective on longevity regulation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

The nascent polypeptide-associated complex is a key regulator of proteostasis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Aneuploidy causes proteotoxic stress in yeast

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Mass spectrometry-based proteomics and network biology

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Proteomic analysis of age-dependent changes in protein solubility identifies genes that modulate lifespan

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Hsp42 is required for sequestration of protein aggregates into deposition sites in Saccharomyces cerevisiae

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Stable-isotope labeling with amino acids in nematodes.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Protein solubility and protein homeostasis: a generic view of protein misfolding disorders

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Molecular chaperones in protein folding and proteostasis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Global quantification of mammalian gene expression control

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Quantitative, high-resolution proteomics for data-driven systems biology

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Andromeda: a peptide search engine integrated into the MaxQuant environment

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Accurate quantification of more than 4000 mouse tissue proteins reveals minimal proteome changes during aging

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Protein homeostasis and aging in neurodegeneration

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Widespread protein aggregation as an inherent part of aging in C. elegans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Reduced IGF-1 signaling delays age-associated proteotoxicity in mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Global prediction of tissue-specific gene expression and context-dependent gene networks in Caenorhabditis elegans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Universal sample preparation method for proteome analysis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Integrating the stress response: lessons for neurodegenerative diseases from C. elegans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Misfolding of proteins with a polyglutamine expansion is facilitated by proteasomal chaperones

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Misfolded proteins partition between two distinct quality control compartments

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Adapting proteostasis for disease intervention

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Mfuzz: a software package for soft clustering of microarray data

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Genes misregulated in C. elegans deficient in Dicer, RDE-4, or RDE-1 are enriched for innate immunity genes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Opposing activities protect against age-onset proteotoxicity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Progressive disruption of cellular protein folding in models of polyglutamine diseases.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Some like it hot: the structure and function of small heat-shock proteins.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Oxidants, oxidative stress and the biology of ageing

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

A C. elegans mutant that lives twice as long as wild type

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

The CamSol method of rational design of protein mutants with enhanced solubility.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

RPN-6 determines C. elegans longevity under proteotoxic stress conditions

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Firefly luciferase mutants as sensors of proteome stress

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

A relationship between mRNA expression levels and protein solubility in E. coli.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Prediction of aggregation-prone regions in structured proteins

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Quantitative mass spectrometry identifies insulin signaling targets in C. elegans

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Modulated microRNA expression during adult lifespan in Caenorhabditis elegans.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Small heat-shock proteins function in the insoluble protein complex.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Metabolic labeling of C. elegans and D. melanogaster for quantitative proteomics.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4643853

Microarray analysis of gene expression with age in individual nematodes

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25957690

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25957690

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Deep proteome and transcriptome mapping of a human cancer cell line

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1038/MSB.2011.81

ProteomeXchange provides globally coordinated proteomics data submission and dissemination

1 reference

5 May 2024

https://opencitations.net/index/api/v1/citations/10.1038/NBT.2839

Identifiers

DOI

10.1016/J.CELL.2015.03.032

1 reference

2 August 2017

1 reference

2 August 2017

1 reference