Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons. (Q34462515)

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English	Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons.	scientific article

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10 November 2019

Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons (English)

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10 November 2019

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R J Crowder

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10 November 2019

R S Freeman

2

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1 April 1998

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10 November 2019

Journal of Neuroscience

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10 November 2019

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10 November 2019

2933-2943

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10 November 2019

8

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10 November 2019

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of phosphatidylinositol 3-kinase by epidermal growth factor, basic fibroblast growth factor, and nerve growth factor in PC12 pheochromocytoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison between the timing of JNK activation, c-Jun phosphorylation, and onset of death commitment in sympathetic neurones.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogen-activated protein kinase-independent pathways mediate the effects of nerve growth factor and cAMP on neuronal survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of apoptosis in cultured rat sympathetic neurons after nerve growth factor withdrawal

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophin signal transduction by the Trk receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of ras p21 in neurotrophin-induced response of sensory, but not sympathetic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of BCL-2 in the survival and function of developing and mature sympathetic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The trk proto-oncogene encodes a receptor for nerve growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Active p21Ras is sufficient for rescue of NGF-dependent rat sympathetic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Trk family of neurotrophin receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morphometric analysis of rat superior cervical ganglion after axotomy and nerve growth factor treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neutralizing anti-p21ras Fabs suppress rat sympathetic neuron survival induced by NGF, LIF, CNTF and cAMP

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning of rat RAC protein kinase alpha and beta and their association with protein kinase C zeta

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PI 3-kinase: structural and functional analysis of intersubunit interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidylinositol 3-kinase is activated by nerve growth factor and epidermal growth factor in PC12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth factor-dependent survival of rodent fibroblasts requires phosphatidylinositol 3-kinase but is independent of pp70S6K activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Ca2+ channels in the ability of membrane depolarization to prevent neuronal death induced by trophic-factor deprivation: evidence that levels of internal Ca2+ determine nerve growth factor dependence of sympathetic ganglion cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical characterization of programmed cell death in NGF-deprived sympathetic neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of neuronal survival by the serine-threonine protein kinase Akt

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor and potassium depolarization maintain neuronal survival by distinct pathways: possible involvement of PI 3-kinase in IGF-1 signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of p42 and p44 mitogen-activated protein kinase activity by PD98059 does not suppress nerve growth factor-induced survival of sympathetic neurones

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidylinositol-3-OH kinase as a direct target of Ras

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proliferative inhibition by dominant-negative Ras rescues naive and neuronally differentiated PC12 cells from apoptotic death

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like Growth Factor 1 Inhibits Apoptosis Using the Phosphatidylinositol 3′-Kinase and Mitogen-activated Protein Kinase Pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of cell cycle-related gene expression in postmitotic neurons: selective induction of Cyclin D1 during programmed cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nerve growth factor binds to the 140 kd trk proto-oncogene product and stimulates its association with the src homology domain of phospholipase C gamma 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of activation of protein kinase B by insulin and IGF-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell death during development of the nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of Trk binding sites for SHC and phosphatidylinositol 3'-kinase and formation of a multimeric signaling complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of phosphatidylinositol 3-kinase activity blocks depolarization- and insulin-like growth factor I-mediated survival of cerebellar granule cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of phosphoinositide 3-kinase in insulin- or IGF-1-induced membrane ruffling

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of cyclin-dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/9526010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.18-08-02933.1998

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9526010%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9526010%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9526010%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

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