Tissue-type plasminogen activator: variants and crystal/solution structures demarcate structural determinants of function (Q34452848)

2 August 2017

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title

Tissue-type plasminogen activator: variants and crystal/solution structures demarcate structural determinants of function (English)

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2 August 2017

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Bode W

1

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PubMed ID

9434908

2 August 2017

Renatus M

series ordinal

2

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2 August 2017

1 December 1997

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Current Opinion in Structural Biology

2 August 2017

1 reference

2 August 2017

7

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2 August 2017

6

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2 August 2017

865-872

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Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli

2 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

The structure of the human tissue-type plasminogen activator gene: correlation of intron and exon structures to functional and structural domains

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

The role of the lysyl binding site of tissue-type plasminogen activator in the interaction with a forming fibrin clot

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

Structural features mediating fibrin selectivity of vampire bat plasminogen activators

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

Molecular biology of plasminogen activators: what are the clinical implications of drug design?

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

New clot busters threaten Genentech's tPA

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

Mechanisms of plasminogen activation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

Solution structure of the fibrin binding finger domain of tissue-type plasminogen activator determined by 1H nuclear magnetic resonance

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

Crystal structure of the kringle 2 domain of tissue plasminogen activator at 2.4-.ANG. resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

Solution structure of the tissue-type plasminogen activator kringle 2 domain complexed to 6-aminohexanoic acid an antifibrinolytic drug

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

The solution structure and backbone dynamics of the fibronectin type I and epidermal growth factor-like pair of modules of tissue-type plasminogen activator

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

The 2.3 A crystal structure of the catalytic domain of recombinant two-chain human tissue-type plasminogen activator

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

Structural mapping of the active site specificity determinants of human tissue-type plasminogen activator. Implications for the design of low molecular weight substrates and inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

Lysine 156 promotes the anomalous proenzyme activity of tPA: X-ray crystal structure of single-chain human tPA.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

Catalytic domain structure of vampire bat plasminogen activator: a molecular paradigm for proteolysis without activation cleavage

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

Variants of tissue-type plasminogen activator which display substantially enhanced stimulation by fibrin

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

Converting tissue-type plasminogen activator into a zymogen.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

Converting tissue type plasminogen activator into a zymogen. Important role of Lys156.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

Ligand binding to the tissue-type plasminogen activator kringle 2 domain: structural characterization by 1H-NMR

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

Complexation of the tissue plasminogen activator protease with benzamidine-type inhibitors: interference by the kringle 2 module.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

Physical characterization of recombinant tissue plasminogen activator

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

Origins of the specificity of tissue-type plasminogen activator

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

Serpin-resistant mutants of human tissue-type plasminogen activator

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

A region of tissue plasminogen activator that affects plasminogen activation differentially with various fibrin(ogen)-related stimulators

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

Mapping of the catalytic site of CHO‐t‐PA and the t‐PA variant BM 06.022 by synthetic inhibitors and substrates

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

The crystal structure of the catalytic domain of human urokinase-type plasminogen activator

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

Distinguishing the specificities of closely related proteases. Role of P3 in substrate and inhibitor discrimination between tissue-type plasminogen activator and urokinase.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

Substrate specificity of tissue type plasminogen activator. Characterization of the fibrin independent specificity of t-PA for plasminogen

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

Distinct mechanisms contribute to stringent substrate specificity of tissue-type plasminogen activator

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

Identification of a hydrophobic exosite on tissue type plasminogen activator that modulates specificity for plasminogen.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

Structural basis of the activation and action of trypsin

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding. II. The binding of the pancreatic trypsin inhibitor and of isoleucine-valine and of sequentially related peptides to trypsinogen and to p-guanidinobenzoate-tryp

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

Conformational similarities between one-chain and two-chain tissue plasminogen activator (t-PA): implications to the activation mechanism on one-chain t-PA

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

Converting tissue plasminogen activator to a zymogen: a regulatory triad of Asp-His-Ser

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

Study of tissue-type plasminogen activator binding sites on fibrin using distinct fragments of fibrinogen

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

Variants of tissue-type plasminogen activator with substantially enhanced response and selectivity toward fibrin co-factors

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

The plasminogen activator family from the salivary gland of the vampire bat Desmodus rotundus: cloning and expression

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980159-5

7 January 2021

10.1016/S0959-440X(97)80159-5

Identifiers

DOI

1 reference

2 August 2017

1 reference

PubMed ID

9434908