A phase 2 study of MK-0457 in patients with BCR-ABL T315I mutant chronic myelogenous leukemia and philadelphia chromosome-positive acute lymphoblastic leukemia. (Q34448958)

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English	A phase 2 study of MK-0457 in patients with BCR-ABL T315I mutant chronic myelogenous leukemia and philadelphia chromosome-positive acute lymphoblastic leukemia.	scientific article

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12 March 2020

A phase 2 study of MK-0457 in patients with BCR-ABL T315I mutant chronic myelogenous leukemia and philadelphia chromosome-positive acute lymphoblastic leukemia (English)

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12 March 2020

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Cristina Papayannidis

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T Hughes

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12 March 2020

Jorge Eduardo Cortes

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J Cortes

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J F Seymour

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D W Kim

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E Rubin

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A Haregewoin

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J Clark

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P Watson

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I Dufva

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J L Jimenez

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F-X Mahon

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P Rousselot

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G Martinelli

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A Nagler

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F J Giles

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publication date

15 August 2014

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12 March 2020

Blood Cancer Journal

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12 March 2020

4

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12 March 2020

e238

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12 March 2020

copyright license

Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International

1 August 2014

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April 2022 Public Data File from Crossref

copyright status

0 references

https://scigraph.springernature.com/pub.10.1038/bcj.2014.60

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A phase 2 trial of ponatinib in Philadelphia chromosome-positive leukemias

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Ponatinib in refractory Philadelphia chromosome-positive leukemias

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The combination of alisertib, an investigational Aurora kinase A inhibitor, and docetaxel promotes cell death and reduces tumor growth in preclinical cell models of upper gastrointestinal adenocarcinomas

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Phase 2 study of subcutaneous omacetaxine mepesuccinate after TKI failure in patients with chronic-phase CML with T315I mutation

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The potential role of Aurora kinase inhibitors in haematological malignancies

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6 July 2018

Phase I dose escalation study of MK-0457, a novel Aurora kinase inhibitor, in adult patients with advanced solid tumors

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Chronic myeloid leukemia: an update of concepts and management recommendations of European LeukemiaNet

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Overcoming resistance in chronic myelogenous leukemia

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Discovery and development of aurora kinase inhibitors as anticancer agents

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Enhancement of radiation response by inhibition of Aurora-A kinase using siRNA or a selective Aurora kinase inhibitor PHA680632 in p53-deficient cancer cells

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Aurora-A regulation of nuclear factor-kappaB signaling by phosphorylation of IkappaBalpha

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The Aurora kinase inhibitor VX-680 induces endoreduplication and apoptosis preferentially in cells with compromised p53-dependent postmitotic checkpoint function

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Mitotic kinases: the key to duplication, segregation, and cytokinesis errors, chromosomal instability, and oncogenesis

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Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases

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Imatinib mesylate (Glivec, Gleevec) in the treatment of chronic myelogenous leukemia (CML) and gastrointestinal stromal tumors (GIST).

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VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

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Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining

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6 July 2018

MK-0457, an Aurora kinase and BCR-ABL inhibitor, is active in patients with BCR-ABL T315I leukemia.

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https://api.crossref.org/works/10.1038%2FBCJ.2014.60

21 January 2018

Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis

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Structural basis for potent inhibition of the Aurora kinases and a T315I multi-drug resistant mutant form of Abl kinase by VX-680.

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MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/25127392

12 December 2020

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10.1038/BCJ.2014.60

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12 March 2020

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12 March 2020

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12 March 2020

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