Pharmacological reactivation of inactive genes: the fragile X experience (Q34446607)

2 August 2017

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title

Pharmacological reactivation of inactive genes: the fragile X experience (English)

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2 August 2017

P Chiurazzi

1

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PubMed ID

11719276

2 August 2017

G Neri

series ordinal

2

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2 August 2017

1 October 2001

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2 August 2017

Brain Research Bulletin

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2 August 2017

56

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2 August 2017

3-4

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2 August 2017

383-387

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Nucleus basalis magnocellularis and hippocampus are the major sites of FMR-1 expression in the human fetal brain.

2 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Human and murine FMR-1: alternative splicing and translational initiation downstream of the CGG-repeat.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

FMR1 protein: conserved RNP family domains and selective RNA binding

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Transgenic mouse models of neurodegenerative disease caused by CAG/polyglutamine expansions

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Creation of genomic methylation patterns

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

In vitro reactivation of the FMR1 gene involved in fragile X syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Synergistic effect of histone hyperacetylation and DNA demethylation in the reactivation of the FMR1 gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Acetylated histones are associated with FMR1 in normal but not fragile X-syndrome cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Abnormal dendritic spines in fragile X knockout mice: maturation and pruning deficits

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

The fragile X mental retardation protein is associated with poly(A)+ mRNA in actively translating polyribosomes

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Secondary structures in d(CGG) and d(CCG) repeat tracts

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

A point mutation in the FMR-1 gene associated with fragile X mental retardation

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Variable FMR1 gene methylation of large expansions leads to variable phenotype in three males from one fragile X family

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

The FMR-1 protein is cytoplasmic, most abundant in neurons and appears normal in carriers of a fragile X premutation

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Evolution of simple repeats in DNA and their relation to human disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

DNA methylation models histone acetylation

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Cell death in polyglutamine diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Translational suppression by trinucleotide repeat expansion at FMR1.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Fragile X syndrome and deletions in FMR1: New case and review of the literature

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Identification and characterization of a family of mammalian methyl-CpG binding proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Tissue specific expression of FMR-1 provides evidence for a functional role in fragile X syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Analysis of neocortex in three males with the fragile X syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Evidence for altered Fragile-X mental retardation protein expression in response to behavioral stimulation

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

The fragile X mental retardation protein is associated with ribosomes

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Stalling of human DNA (cytosine-5) methyltransferase at single-strand conformers from a site of dynamic mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

The CAG/polyglutamine tract diseases: gene products and molecular pathogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Interaction of the transcription factors USF1, USF2, and alpha -Pal/Nrf-1 with the FMR1 promoter. Implications for Fragile X mental retardation syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA

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https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Triplet repeat expansion in neuromuscular disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Intragenic loss of function mutations demonstrate the primary role of FMR1 in fragile X syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

A deletion of 1.6 kb proximal to the CGG repeat of the FMR1 gene causes the clinical phenotype of the fragile X syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Trinucleotide repeats associated with human disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Epilepsy and fragile X syndrome: a follow-up study.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

X-linked mental retardation

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https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

(Over)correction of FMR1 deficiency with YAC transgenics: behavioral and physical features

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Absence of expression of the FMR-1 gene in fragile X syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Neuroanatomy of fragile X syndrome: the posterior fossa

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Neuroanatomy of fragile X syndrome: the temporal lobe

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Neurodevelopmental effects of the FMR-1 full mutation in humans.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Fragile X mental retardation: prevalence in a group of institutionalized patients in Italy and description of a novel EEG pattern.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Alternative splicing of exon 14 determines nuclear or cytoplasmic localisation of fmr1 protein isoforms

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Normal phenotype in two brothers with a full FMR1 mutation.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Epigenetic variation illustrated by DNA methylation patterns of the fragile-X gene FMR1

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

FMRP is associated to the ribosomes via RNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

An extensive de novo deletion removing FMR1 in a patient with mental retardation and the fragile X syndrome phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Prevalence of fragile X syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Characterization and localization of the FMR-1 gene product associated with fragile X syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Characterization of FMR1 proteins isolated from different tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Alternative splicing in the fragile X gene FMR1.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

FMR1 fully expanded mutation with minimal methylation in a high functioning fragile X male

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

Synaptic synthesis of the Fragile X protein: possible involvement in synapse maturation and elimination.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2801%2900571-8

7 January 2021

10.1016/S0361-9230(01)00571-8

Identifiers

DOI

1 reference

2 August 2017

1 reference

PubMed ID

11719276