Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation (Q34441762)

2 August 2017

Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation (English)

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Ring finger and CCCH-type zinc finger domains 2

2 August 2017

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Zinc finger CCCH type containing 12A

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Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta

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Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta

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MALT1 paracaspase

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RING CCCH (C3H) domains 1

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author

Ingo Schmitz

20

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2 August 2017

24

Daniel Krappmann

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2 August 2017

27

Mathias Heikenwalder

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Marc Schmidt-Supprian

21

Marc Schmidt-Supprian

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Vigo Heissmeyer

Vigo Heissmeyer

28

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Hans-Joachim Anders

Hans-Joachim Anders

19

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Axel Kallies

26

Axel Kallies

1 reference

2 August 2017

Katharina M Jeltsch

1

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2 August 2017

Desheng Hu

2

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2 August 2017

Sven Brenner

3

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2 August 2017

Jessica Zöller

4

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2 August 2017

Gitta A Heinz

5

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2 August 2017

Daniel Nagel

6

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2 August 2017

Katharina U Vogel

7

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2 August 2017

Nina Rehage

8

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2 August 2017

Sebastian C Warth

9

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2 August 2017

Stephanie L Edelmann

10

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2 August 2017

Renee Gloury

11

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2 August 2017

Nina Martin

12

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2 August 2017

Claudia Lohs

13

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2 August 2017

Maciej Lech

14

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2 August 2017

Jenny E Stehklein

15

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2 August 2017

Arie Geerlof

16

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2 August 2017

Elisabeth Kremmer

17

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2 August 2017

Achim Weber

18

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2 August 2017

Marc Schmidt-Supprian

21

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2 August 2017

Mingui Fu

22

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2 August 2017

Helmut Holtmann

23

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2 August 2017

Jürgen Ruland

25

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2 August 2017

language of work or name

English

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publication date

5 October 2014

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2 August 2017

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2 August 2017

15

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2 August 2017

11

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2 August 2017

1079-1089

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Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay

2 August 2017

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Targeted disruption of MCPIP1/Zc3h12a results in fatal inflammatory disease

21 January 2018

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A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

21 January 2018

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MCPIP1 deficiency in mice results in severe anemia related to autoimmune mechanisms

21 January 2018

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Post-transcriptional regulatory networks in immunity.

21 January 2018

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Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression

21 January 2018

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Roquin promotes constitutive mRNA decay via a conserved class of stem-loop recognition motifs.

21 January 2018

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Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation

21 January 2018

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Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA

21 January 2018

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The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1

21 January 2018

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Malt1-induced cleavage of regnase-1 in CD4(+) helper T cells regulates immune activation

21 January 2018

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MCPIP1 ribonuclease antagonizes dicer and terminates microRNA biogenesis through precursor microRNA degradation

21 January 2018

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Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation

21 January 2018

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The ROQ domain of Roquin recognizes mRNA constitutive-decay element and double-stranded RNA

21 January 2018

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T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20

21 January 2018

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The proteolytic activity of the paracaspase MALT1 is key in T cell activation

21 January 2018

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Multifunctional roles for MALT1 in T-cell activation.

21 January 2018

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A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains.

21 January 2018

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Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines.

21 January 2018

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T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1.

21 January 2018

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The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells

21 January 2018

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Selective C-Rel activation via Malt1 controls anti-fungal T(H)-17 immunity by dectin-1 and dectin-2.

21 January 2018

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Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination

21 January 2018

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Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis.

21 January 2018

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Loss of Roquin induces early death and immune deregulation but not autoimmunity

21 January 2018

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Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL.

21 January 2018

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Structural determinants of MALT1 protease activity

21 January 2018

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MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-kappaB signaling

21 January 2018

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T cell-derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia.

21 January 2018

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IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells

21 January 2018

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The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

21 January 2018

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IκB(NS) protein mediates regulatory T cell development via induction of the Foxp3 transcription factor

21 January 2018

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c-Rel promotes type 1 and type 17 immune responses during Leishmania major infection

21 January 2018

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The Th17 immune response is controlled by the Rel-RORγ-RORγ T transcriptional axis

21 January 2018

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The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells

21 January 2018

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Interferon regulatory factor 4 sustains CD8(+) T cell expansion and effector differentiation

21 January 2018

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Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1

21 January 2018

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HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

21 January 2018

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Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection

21 January 2018

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Defective TCR expression in transgenic mice constructed using cDNA-based α- and β-chain genes under the control of heterologous regulatory elements

21 January 2018

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Mouse Eri1 interacts with the ribosome and catalyzes 5.8S rRNA processing

21 January 2018

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Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens.

21 January 2018

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Modeling and analysis on the internal impact of a Stewart platform utilized for spacecraft docking

21 January 2018

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IκBζ regulates TH17 development by cooperating with ROR nuclear receptors

21 January 2018

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The NF- B Transcription Factor c-Rel Is Required for Th17 Effector Cell Development in Experimental Autoimmune Encephalomyelitis

21 January 2018

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12 December 2020

A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.

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12 December 2020

The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4

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12 December 2020

Interferon-γ excess leads to pathogenic accumulation of follicular helper T cells and germinal centers

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12 December 2020

Adenoviral transduction of naive CD4 T cells to study Treg differentiation.

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12 December 2020

Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease

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12 December 2020

DO11.10 and OT-II T cells recognize a C-terminal ovalbumin 323-339 epitope

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12 December 2020

Identifiers

DOI

10.1038/NI.3008

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2 August 2017

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