Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index (Q34432501)

2 August 2017

Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index (English)

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2 August 2017

antimicrobial peptide

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4

Robert E W Hancock

1 reference

2 August 2017

Yuxin Chen

1

1 reference

2 August 2017

Colin T Mant

2

1 reference

2 August 2017

Susan W Farmer

3

1 reference

2 August 2017

Michael L Vasil

5

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2 August 2017

Robert S Hodges

6

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2 August 2017

language of work or name

English

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publication date

27 January 2005

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2 August 2017

14

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Journal of Biological Chemistry

inferred from page(s)

published in

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2 August 2017

280

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2 August 2017

13

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2 August 2017

12316-12329

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Effect of variations in the structure of a polyleucine-based alpha-helical transmembrane peptide on its interaction with phosphatidylethanolamine Bilayers

2 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

New drugs for Gram-positive uropathogens

6 July 2018

1 reference

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Infective endocarditis: a review of the best treatment options

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

Effects of single D-amino acid substitutions on disruption of beta-sheet structure and hydrophobicity in cyclic 14-residue antimicrobial peptide analogs related to gramicidin S.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

The design of Jemboss: a graphical user interface to EMBOSS.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

Host-defense antimicrobial peptides: importance of structure for activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

Cationic peptides: distribution and mechanisms of resistance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

Determination of stereochemistry stability coefficients of amino acid side-chains in an amphipathic alpha-helix.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

Role of membranes in the activities of antimicrobial cationic peptides

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

Antimicrobial peptides: properties and applicability

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

Development of the structural basis for antimicrobial and hemolytic activities of peptides based on gramicidin S and design of novel analogs using NMR spectroscopy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

Lipid-induced conformation and lipid-binding properties of cytolytic and antimicrobial peptides: determination and biological specificity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

Interaction of antimicrobial peptides with biological and model membranes: structural and charge requirements for activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

Why and how are peptide-lipid interactions utilized for self-defense? Magainins and tachyplesins as archetypes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

Animal antimicrobial peptides: an overview

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

Determinants of recombinant production of antimicrobial cationic peptides and creation of peptide variants in bacteria.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

Cationic peptides: a new source of antibiotics

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

The tyrocidine biosynthesis operon of Bacillus brevis: complete nucleotide sequence and biochemical characterization of functional internal adenylation domains

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

Protegrin-1: a broad-spectrum, rapidly microbicidal peptide with in vivo activity.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

Diastereoisomers of cytolysins, a novel class of potent antibacterial peptides

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

Induced conformational states of amphipathic peptides in aqueous/lipid environments

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

The helical hydrophobic moment: a measure of the amphiphilicity of a helix

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

Specificity of lipid-protein interactions as determined by spectroscopic techniques

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

Antimicrobial peptide magainin I from Xenopus skin forms anion-permeable channels in planar lipid bilayers

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

Channel-forming properties of cecropins and related model compounds incorporated into planar lipid membranes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

6 July 2018

Lipids of mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

Effect of preferred binding domains on peptide retention behavior in reversed-phase chromatography: amphipathic alpha-helices.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

Shortened cecropin A-melittin hybrids. Significant size reduction retains potent antibiotic activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

The crisis in antibiotic resistance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

Design of model amphipathic peptides having potent antimicrobial activities

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

Interaction of antimicrobial dermaseptin and its fluorescently labeled analogues with phospholipid membranes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

Electrically gated ionic channels in lipid bilayers

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

Hydrogen-deuterium substitution and solvent effects on the nitrogen-15 nuclear magnetic resonance of gramicidin S: evaluation of secondary structure

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

In vivo efficacy of linezolid in combination with gentamicin for the treatment of experimental endocarditis due to methicillin-resistant Staphylococcus aureus.

6 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413406200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413406200

Hydrophobicity, hydrophobic moment and angle subtended by charged residues modulate antibacterial and haemolytic activity of amphipathic helical peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413406200

Structure–activity relationships of de novo designed cyclic antimicrobial peptides based on gramicidin S

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413406200

Dissociation of antimicrobial and hemolytic activities in cyclic peptide diastereomers by systematic alterations in amphipathicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413406200

A repertoire of novel antibacterial diastereomeric peptides with selective cytolytic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413406200

Influence of proline residues on the antibacterial and synergistic activities of alpha-helical peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413406200

Interaction of cationic antimicrobial peptides with model membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413406200

Membrane-bound structure and alignment of the antimicrobial beta-sheet peptide gramicidin S derived from angular and distance constraints by solid state 19F-NMR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413406200

Effect of variations in the structure of a polyleucine-based alpha-helical transmembrane peptide on its interaction with phosphatidylcholine bilayers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413406200

Effect of variations in the structure of a polyleucine-based alpha-helical transmembrane peptide on its interaction with phosphatidylglycerol bilayers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413406200

Induction of amphipathic helical peptide structures in RP-HPLC

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1393284

Optimization of microbial specificity in cyclic peptides by modulation of hydrophobicity within a defined structural framework

27 October 2018

1 reference

12 December 2020

Reversed-phase liquid chromatography as a tool in the determination of the hydrophilicity/hydrophobicity of amino acid side-chains at a ligand-receptor interface in the presence of different aqueous environments. I. Effect of varying receptor hydrop

1 reference

12 December 2020

Reversed-phase liquid chromatography as a tool in the determination of the hydrophilicity/hydrophobicity of amino acid side-chains at a ligand-receptor interface in the presence of different aqueous environments. II. Effect of varying peptide ligand

1 reference

12 December 2020

A novel method to measure self-association of small amphipathic molecules: temperature profiling in reversed-phase chromatography

1 reference

12 December 2020

Temperature profiling of polypeptides in reversed-phase liquid chromatography. I. Monitoring of dimerization and unfolding of amphipathic alpha-helical peptides

1 reference

12 December 2020

Temperature profiling of polypeptides in reversed-phase liquid chromatography. II. Monitoring of folding and stability of two-stranded alpha-helical coiled-coils

1 reference

12 December 2020

Reviving the antibiotic miracle?

1 reference

12 December 2020

1 reference

12 December 2020

Selective lysis of bacteria but not mammalian cells by diastereomers of melittin: structure-function study

1 reference

12 December 2020

Relationship of sidechain hydrophobicity and alpha-helical propensity on the stability of the single-stranded amphipathic alpha-helix

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M413406200

1 reference

2 August 2017

1 reference

2 August 2017

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