Clinical significance of animal seizure models and mechanism of action studies of potential antiepileptic drugs (Q34420834)

2 August 2017

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title

Clinical significance of animal seizure models and mechanism of action studies of potential antiepileptic drugs (English)

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2 August 2017

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H S White

1

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2 August 2017

1 January 1997

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2 August 2017

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2 August 2017

38 Suppl 1

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2 August 2017

S9-17

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The early identification of anticonvulsant activity: role of the maximal electroshock and subcutaneous pentylenetetrazol seizure models.

2 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1157.1997.TB04523.X

Calcium currents in rat thalamocortical relay neurones: kinetic properties of the transient, low-threshold current.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1157.1997.TB04523.X

Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1157.1997.TB04523.X

Effects induced by the antiepileptic drug valproic acid upon the ionic currents recorded in rat neocortical neurons in cell culture.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1157.1997.TB04523.X

Barbiturate regulation of kinetic properties of the GABAA receptor channel of mouse spinal neurones in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1157.1997.TB04523.X

Differential regulation of gamma-aminobutyric acid receptor channels by diazepam and phenobarbital

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1157.1997.TB04523.X

Benzodiazepine and beta-carboline regulation of single GABAA receptor channels of mouse spinal neurones in culture.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1157.1997.TB04523.X

Diazepam and (--)-pentobarbital: fluctuation analysis reveals different mechanisms for potentiation of gamma-aminobutyric acid responses in cultured central neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1157.1997.TB04523.X

Cloned GABA receptors are maintained in a stable cell line: allosteric and channel properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1157.1997.TB04523.X

Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1157.1997.TB04523.X

Blockade of epileptic responses in the photosensitive baboon, Papio papio, by two irreversible inhibitors of GABA-transaminase, ?-acetylenic GABA (4-amino-hex-5-ynoic acid) and ?-vinyl GABA (4-amino-hex-5-enoic acid)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1157.1997.TB04523.X

Audiogenic seizure protection by elevated brain GABA concentration in mice: effects of gamma-acetylenic gaba and gamma-vinyl GABA, two irreversible GABA-T inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1157.1997.TB04523.X

Anti-seizure and anti-epileptogenic effect of gamma-vinyl gamma-aminobutyric acid in amygdaloid kindling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1157.1997.TB04523.X

Pharmacological investigation of gamma-aminobutyric acid (GABA) and fully-developed generalized seizures in the amygdala-kindled rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1157.1997.TB04523.X

Relative anticonvulsant effects of GABAmimetic and GABA modulatory agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1157.1997.TB04523.X

Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1157.1997.TB04523.X

gamma-Vinyl GABA (4-amino-hex-5-enoic acid), a new selective irreversible inhibitor of GABA-T: effects on brain GABA metabolism in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1157.1997.TB04523.X

An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1157.1997.TB04523.X

Studies on the mechanism of action of the novel anticonvulsant lamotrigine (Lamictal) using primary neurological cultures from rat cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1157.1997.TB04523.X

Inhibition by GABA, baclofen and gabapentin of dopamine release from rabbit caudate nucleus: are there common or different sites of action?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1157.1997.TB04523.X

Gabapentin increases aminooxyacetic acid-induced GABA accumulation in several regions of rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1157.1997.TB04523.X

Transient presence of GABA in astrocytes of the developing optic nerve.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1157.1997.TB04523.X

Characterisation of [3H]gabapentin binding to a novel site in rat brain: homogenate binding studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1157.1997.TB04523.X

Characterization of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1157.1997.TB04523.X

A review of the preclinical pharmacology of tiagabine: a potent and selective anticonvulsant GABA uptake inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1157.1997.TB04523.X

(R)-N-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl]nipecotic acid binds with high affinity to the brain gamma-aminobutyric acid uptake carrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1157.1997.TB04523.X

The gamma-aminobutyric acid (GABA) uptake inhibitor, tiagabine, increases extracellular brain levels of GABA in awake rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1157.1997.TB04523.X

A neuropharmacological evaluation of felbamate as a novel anticonvulsant

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1157.1997.TB04523.X

Felbamate modulates the strychnine-insensitive glycine receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1157.1997.TB04523.X

Mechanism of action of the anticonvulsant felbamate: opposing effects on N-methyl-D-aspartate and gamma-aminobutyric acidA receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1157.1997.TB04523.X

10.1111/J.1528-1157.1997.TB04523.X

21 January 2018

Identifiers

DOI

1 reference

2 August 2017

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PubMed ID

9092952