Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA. (Q34416582)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755925%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

title

Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA (English)

1 reference

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15 March 2020

1 reference

1

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15 March 2020

Jerome Wielens

2

1 reference

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15 March 2020

Tracy L Nero

3

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15 March 2020

Craig J Morton

5

1 reference

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15 March 2020

Michael W Parker

6

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15 March 2020

author name string

Larissa Doughty

4

1 reference

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15 March 2020

language of work or name

English

0 references

publication date

23 April 2014

1 reference

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15 March 2020

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15 March 2020

volume

4

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15 March 2020

page(s)

4765

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

15 March 2020

copyright license

start time

23 April 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1038/srep04765

0 references

cites work

Understanding the biological context of NS5A-host interactions in HCV infection: a network-based approach

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483

HCV NS5A inhibitors in development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483

In vitro activity of daclatasvir on hepatitis C virus genotype 3 NS5A.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483

Small molecule inhibitors of the hepatitis C virus-encoded NS5A protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483

Correlation between NS5A dimerization and hepatitis C virus replication

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483

Structure-based discovery of substituted 4,5'-bithiazoles as novel DNA gyrase inhibitors

6 July 2018

1 reference

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Inhibition of basal FGF receptor signaling by dimeric Grb2

6 July 2018

1 reference

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Discovery, structure-activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidase

6 July 2018

1 reference

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Mediation of the antiapoptotic activity of Bcl-xL protein upon interaction with VDAC1 protein

6 July 2018

1 reference

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Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483

In vitro activity of BMS-790052 on hepatitis C virus genotype 4 NS5A.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483

Microscale thermophoresis as a sensitive method to quantify protein: nucleic acid interactions in solution

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483

An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483

Distinct functions of NS5A in hepatitis C virus RNA replication uncovered by studies with the NS5A inhibitor BMS-790052

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483

The hepatitis C virus NS5A inhibitor (BMS-790052) alters the subcellular localization of the NS5A non-structural viral protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483

Small molecules targeting hepatitis C virus-encoded NS5A cause subcellular redistribution of their target: insights into compound modes of action

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483

Domain 3 of NS5A protein from the hepatitis C virus has intrinsic alpha-helical propensity and is a substrate of cyclophilin A.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483

Recombinant HCV variants with NS5A from genotypes 1-7 have different sensitivities to an NS5A inhibitor but not interferon-α.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483

Hepatitis C virus nonstructural protein 5A: biochemical characterization of a novel structural class of RNA-binding proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483

All three domains of the hepatitis C virus nonstructural NS5A protein contribute to RNA binding

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483

Resistance analysis of the hepatitis C virus NS5A inhibitor BMS-790052 in an in vitro replicon system

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483

Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483

Identification of Hepatitis C Virus NS5A Inhibitors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483

Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483

Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483

Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996483

Characterizations of HCV NS5A replication complex inhibitors.

6 July 2018

1 reference

Pharmacological disruption of hepatitis C NS5A protein intra- and intermolecular conformations.

21 January 2018

1 reference

The domain 2 of the HCV NS5A protein is intrinsically unstructured

21 January 2018

1 reference

Domain 2 of nonstructural protein 5A (NS5A) of hepatitis C virus is natively unfolded.

21 January 2018

1 reference

Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS-790052 in humans: in vitro and in vivo correlations.

21 January 2018

1 reference

The effects of NS5A inhibitors on NS5A phosphorylation, polyprotein processing and localization.

21 January 2018

1 reference

Direct detection of antibody concentration and affinity in human serum using microscale thermophoresis

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24755925

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SREP04765

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755925%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

15 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755925%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24755925%20AND%20SRC:MED&resulttype=core&format=json