Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications (Q34412131)

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8 February 2020

title

Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications (English)

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8 February 2020

1

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8 February 2020

Jan J. Enghild

5

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8 February 2020

author name string

Masahide Kashiwagi

2

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8 February 2020

Robert Visse

3

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8 February 2020

Jonathan Jones

4

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8 February 2020

Keith Brew

6

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8 February 2020

Hideaki Nagase

7

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8 February 2020

language of work or name

English

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publication date

1 October 2010

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8 February 2020

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8 February 2020

volume

431

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8 February 2020

issue

1

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8 February 2020

page(s)

113-122

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Creative Commons Attribution-NonCommercial 2.5 Generic

8 February 2020

copyright license

start time

25 July 2019

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Structural determinants of the ADAM inhibition by TIMP-3: crystal structure of the TACE-N-TIMP-3 complex

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Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5

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Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.

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ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

6 July 2018

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Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

6 July 2018

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ADAM28 is activated by MMP-7 (matrilysin-1) and cleaves insulin-like growth factor binding protein-3

6 July 2018

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Catalytic activity of human ADAM33

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TIMP-3 inhibits aggrecanase-mediated glycosaminoglycan release from cartilage explants stimulated by catabolic factors

6 July 2018

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Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing

6 July 2018

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E. coli expression of TIMP-4 and comparative kinetic studies with TIMP-1 and TIMP-2: insights into the interactions of TIMPs and matrix metalloproteinase 2 (gelatinase A)

6 July 2018

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Mapping and characterization of the functional epitopes of tissue inhibitor of metalloproteinases (TIMP)-3 using TIMP-1 as the scaffold: a new frontier in TIMP engineering

6 July 2018

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The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs

6 July 2018

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ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors

6 July 2018

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Identification of the (183)RWTNNFREY(191) region as a critical segment of matrix metalloproteinase 1 for the expression of collagenolytic activity

6 July 2018

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6 July 2018

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Residue 2 of TIMP-1 is a major determinant of affinity and specificity for matrix metalloproteinases but effects of substitutions do not correlate with those of the corresponding P1' residue of substrate

6 July 2018

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Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1

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TIMP-3 inhibits the procollagen N-proteinase ADAMTS-2.

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12 December 2020

Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments

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12 December 2020

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12 December 2020

The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3

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12 December 2020

TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5)

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

A novel coumarin-labelled peptide for sensitive continuous assays of the matrix metalloproteinases

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12 December 2020

Role of TIMP and MMP inhibition in preventing connective tissue breakdown

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12 December 2020

Mutational study of the amino-terminal domain of human tissue inhibitor of metalloproteinases 1 (TIMP-1) locates an inhibitory region for matrix metalloproteinases

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12 December 2020

Expression of human pro-matrix metalloproteinase 3 that lacks the N-terminal 34 residues in Escherichia coli: autoactivation and interaction with tissue inhibitor of metalloproteinase 1 (TIMP-1)

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12 December 2020

TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3

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12 December 2020

Identifiers

DOI

10.1042/BJ20100725

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8 February 2020

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8 February 2020

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