Phosphorylation-regulated degradation of the tumor-suppressor form of PED by chaperone-mediated autophagy in lung cancer cells. (Q34400928)

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6 March 2020

title

Phosphorylation-regulated degradation of the tumor-suppressor form of PED by chaperone-mediated autophagy in lung cancer cells (English)

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6 March 2020

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Mariarosaria Incoronato

6

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6 March 2020

Maria Monti

8

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6 March 2020

Andrea Ballabio

9

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6 March 2020

Pietro Pucci

10

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6 March 2020

Ana María Cuervo

11

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6 March 2020

Gerolama Condorelli

12

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6 March 2020

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Cristina Quintavalle

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6 March 2020

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Stefania Di Costanzo

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6 March 2020

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Ciro Zanca

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6 March 2020

author name string

Immaculada Tasset

4

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6 March 2020

Alessandro Fraldi

5

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6 March 2020

Peppino Mirabelli

7

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6 March 2020

publication date

1 October 2014

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Journal of Cellular Physiology

6 March 2020

published in

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6 March 2020

volume

229

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6 March 2020

issue

10

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6 March 2020

page(s)

1359-1368

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PEA-15 unphosphorylated at both serine 104 and serine 116 inhibits ovarian cancer cell tumorigenicity and progression through blocking β-catenin

6 March 2020

cites work

1 reference

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The PEA-15/PED protein regulates cellular survival and invasiveness in colorectal carcinomas

6 July 2018

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6 July 2018

Chaperones in autophagy

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Chaperone-mediated autophagy: a unique way to enter the lysosome world

6 July 2018

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Phosphorylation is the switch that turns PEA-15 from tumor suppressor to tumor promoter

6 July 2018

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Hsp27 silencing coordinately inhibits proliferation and promotes Fas-induced apoptosis by regulating the PEA-15 molecular switch

6 July 2018

1 reference

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Chaperone-mediated autophagy is required for tumor growth

6 July 2018

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Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth.

6 July 2018

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PED interacts with Rac1 and regulates cell migration/invasion processes in human non-small cell lung cancer cells.

6 July 2018

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Methods to monitor chaperone-mediated autophagy

6 July 2018

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Retracted: Akt Regulates Drug-Induced Cell Death through Bcl-w Downregulation

6 July 2018

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The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane

6 July 2018

1 reference

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PED is overexpressed and mediates TRAIL resistance in human non-small cell lung cancer

6 July 2018

1 reference

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Chaperone-mediated autophagy in aging and disease

6 July 2018

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PED mediates AKT-dependent chemoresistance in human breast cancer cells

6 July 2018

1 reference

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Phosphorylation of phosphoprotein enriched in astrocytes (PEA-15) regulates extracellular signal-regulated kinase-dependent transcription and cell proliferation

6 July 2018

1 reference

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The multifunctional protein PEA-15 is involved in the control of apoptosis and cell cycle in astrocytes

6 July 2018

1 reference

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Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action

6 July 2018

1 reference

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Multiple members of the mitogen-activated protein kinase family are necessary for PED/PEA-15 anti-apoptotic function

6 July 2018

1 reference

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PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase

6 July 2018

1 reference

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Regulation of lamp2a levels in the lysosomal membrane

6 July 2018

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Import of a cytosolic protein into lysosomes by chaperone-mediated autophagy depends on its folding state

6 July 2018

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Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis

6 July 2018

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PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis

6 July 2018

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A population of rat liver lysosomes responsible for the selective uptake and degradation of cytosolic proteins

6 July 2018

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Peptide sequences that target cytosolic proteins for lysosomal proteolysis

6 July 2018

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Isolation of subcellular organelles

6 July 2018

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The PEA-15 protein regulates autophagy via activation of JNK

6 July 2018

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PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus

21 January 2018

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miR-212 increases tumor necrosis factor-related apoptosis-inducing ligand sensitivity in non-small cell lung cancer by targeting the antiapoptotic protein PED.

21 January 2018

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Epigenetic regulation of miR-212 expression in lung cancer

21 January 2018

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PED/PEA-15 induces autophagy and mediates TGF-beta1 effect on muscle cell differentiation

21 January 2018

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Mechanisms of chaperone-mediated autophagy

21 January 2018

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Phorbol esters induce intracellular accumulation of the anti-apoptotic protein PED/PEA-15 by preventing ubiquitinylation and proteasomal degradation.

21 January 2018

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MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non-small-cell lung cancer through BIM down-regulation

21 January 2018

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21 January 2018

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Selective binding and uptake of ribonuclease A and glyceraldehyde-3-phosphate dehydrogenase by isolated rat liver lysosomes

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24477641

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Selective inhibition of PED protein expression sensitizes B-cell chronic lymphocytic leukaemia cells to TRAIL-induced apoptosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24477641

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/JCP.24569

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24477641%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24477641%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24477641%20AND%20SRC:MED&resulttype=core&format=json