Understanding the drug resistance mechanism of hepatitis C virus NS5B to PF-00868554 due to mutations of the 423 site: a computational study. (Q34399501)

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English	Understanding the drug resistance mechanism of hepatitis C virus NS5B to PF-00868554 due to mutations of the 423 site: a computational study.	scientific article

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scholarly article

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Europe PubMed Central

1 August 2017

Understanding the drug resistance mechanism of hepatitis C virus NS5B to PF-00868554 due to mutations of the 423 site: a computational study. (English)

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Europe PubMed Central

1 August 2017

Hepatitis C virus

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based on heuristic

inferred from title

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24452008%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

author name string

Pingzu Jiao

1

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1 June 2020

Yulin Shen

3

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1 June 2020

Nengzhi Jin

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24452008%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Huanxiang Liu

5

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1 June 2020

publication date

23 January 2014

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1 August 2017

Molecular BioSystems

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1 June 2020

10

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1 June 2020

4

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1 June 2020

767-777

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1 June 2020

Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70498J

21 January 2018

Replication of hepatitis C virus

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70498J

21 January 2018

Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70498J

21 January 2018

Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: a randomized study of treatment duration and ribavirin dose

1 reference

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21 January 2018

Hepatitis C treatment: current and future perspectives

1 reference

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Boceprevir for untreated chronic HCV genotype 1 infection

1 reference

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21 January 2018

Telaprevir for previously untreated chronic hepatitis C virus infection

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70498J

21 January 2018

Response-guided telaprevir combination treatment for hepatitis C virus infection

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70498J

21 January 2018

Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3' nontranslated region are essential for virus replication in vivo

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70498J

21 January 2018

Subcellular localization, stability, and trans-cleavage competence of the hepatitis C virus NS3-NS4A complex expressed in tetracycline-regulated cell lines

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70498J

21 January 2018

Classification of HCV NS5B polymerase inhibitors using support vector machine

1 reference

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21 January 2018

Current perspective of HCV NS5B inhibitors: a review

1 reference

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21 January 2018

Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70498J

21 January 2018

Allosteric inhibitors of hepatitis C polymerase: discovery of potent and orally bioavailable carbon-linked dihydropyrones

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70498J

21 January 2018

Identification and structure-based optimization of novel dihydropyrones as potent HCV RNA polymerase inhibitors

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70498J

21 January 2018

Preclinical Characterization of PF-00868554, a Potent Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70498J

21 January 2018

Discovery of substituted N-phenylbenzenesulphonamides as a novel class of non-nucleoside hepatitis C virus polymerase inhibitors

1 reference

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21 January 2018

Characterization of resistance to the nonnucleoside NS5B inhibitor filibuvir in hepatitis C virus-infected patients

1 reference

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21 January 2018

Biochemical study of the comparative inhibition of hepatitis C virus RNA polymerase by VX-222 and filibuvir

1 reference

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21 January 2018

In silico identification of the potential drug resistance sites over 2009 influenza A (H1N1) virus neuraminidase

1 reference

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21 January 2018

Molecular prediction of oseltamivir efficiency against probable influenza A (H1N1-2009) mutants: molecular modeling approach.

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21 January 2018

Molecular dynamics and free energy studies on the wild-type and double mutant HIV-1 protease complexed with amprenavir and two amprenavir-related inhibitors: mechanism for binding and drug resistance

1 reference

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21 January 2018

Molecular modeling study on the resistance mechanism of HCV NS3/4A serine protease mutants R155K, A156V and D168A to TMC435.

1 reference

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21 January 2018

Understanding the drug resistance mechanism of hepatitis C virus NS3/4A to ITMN-191 due to R155K, A156V, D168A/E mutations: a computational study

1 reference

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21 January 2018

The Amber biomolecular simulation programs

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70498J

21 January 2018

Comparison of multiple Amber force fields and development of improved protein backbone parameters

1 reference

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21 January 2018

Development and testing of a general amber force field

1 reference

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21 January 2018

Comparison of simple potential functions for simulating liquid water

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21 January 2018

Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes

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21 January 2018

Calculating structures and free energies of complex molecules: combining molecular mechanics and continuum models

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21 January 2018

Understanding the structural and energetic basis of inhibitor and substrate bound to the full-length NS3/4A: insights from molecular dynamics simulation, binding free energy calculation and network analysis

1 reference

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21 January 2018

Molecular dynamics with coupling to an external bath

1 reference

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21 January 2018

Theoretical studies on the susceptibility of oseltamivir against variants of 2009 A/H1N1 influenza neuraminidase

1 reference

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21 January 2018

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