Ceftolozane/tazobactam: a novel cephalosporin/β-lactamase inhibitor combination with activity against multidrug-resistant gram-negative bacilli. (Q34393008)

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English	Ceftolozane/tazobactam: a novel cephalosporin/β-lactamase inhibitor combination with activity against multidrug-resistant gram-negative bacilli.	scientific article

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3 March 2020

Ceftolozane/tazobactam: a novel cephalosporin/β-lactamase inhibitor combination with activity against multidrug-resistant gram-negative bacilli (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24352909%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Gram-negative bacteria

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multiple drug resistance

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Sheryl A. Zelenitsky

4

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3 March 2020

Philippe Lagacé-Wiens

7

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3 March 2020

George G Zhanel

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George G Zhanel

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3 March 2020

James A. Karlowsky

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James A Karlowsky

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3 March 2020

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Phillip Chung

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3 March 2020

Heather Adam

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3 March 2020

Andrew Denisuik

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3 March 2020

Frank Schweizer

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3 March 2020

Ethan Rubinstein

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3 March 2020

Alfred S Gin

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3 March 2020

Andrew Walkty

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3 March 2020

Daryl J Hoban

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3 March 2020

Joseph P Lynch

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3 March 2020

publication date

1 January 2014

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3 March 2020

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3 March 2020

74

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3 March 2020

1

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3 March 2020

31-51

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3 March 2020

https://scigraph.springernature.com/pub.10.1007/s40265-013-0168-2

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Ready for a world without antibiotics? The Pensières Antibiotic Resistance Call to Action

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The 10 x '20 Initiative: pursuing a global commitment to develop 10 new antibacterial drugs by 2020.

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10 x '20 Progress--development of new drugs active against gram-negative bacilli: an update from the Infectious Diseases Society of America

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Anti-biofilm and resistance suppression activities of CXA-101 against chronic respiratory infection phenotypes of Pseudomonas aeruginosa strain PAO1.

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21 January 2018

Pseudomonas aeruginosa: resistance and therapeutic options at the turn of the new millennium.

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21 January 2018

Pan-β-lactam resistance development in Pseudomonas aeruginosa clinical strains: molecular mechanisms, penicillin-binding protein profiles, and binding affinities

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21 January 2018

Pseudomonas aeruginosa: all roads lead to resistance

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21 January 2018

Activity of a new antipseudomonal cephalosporin, CXA-101 (FR264205), against carbapenem-resistant and multidrug-resistant Pseudomonas aeruginosa clinical strains

1 reference

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21 January 2018

In vitro potency of CXA-101, a novel cephalosporin, against Pseudomonas aeruginosa displaying various resistance phenotypes, including multidrug resistance

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0168-2

21 January 2018

Activity of cephalosporin CXA-101 (FR264205) against Pseudomonas aeruginosa and Burkholderia cepacia group strains and isolates.

1 reference

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21 January 2018

In vitro and in vivo activities of a new cephalosporin, FR264205, against Pseudomonas aeruginosa

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21 January 2018

Activity of the new cephalosporin CXA-101 (FR264205) against Pseudomonas aeruginosa isolates from chronically-infected cystic fibrosis patients

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21 January 2018

Antimicrobial activity of CXA-101, a novel cephalosporin tested in combination with tazobactam against Enterobacteriaceae, Pseudomonas aeruginosa, and Bacteroides fragilis strains having various resistance phenotypes

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0168-2

21 January 2018

Ceftazidime-avibactam: a novel cephalosporin/β-lactamase inhibitor combination

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21 January 2018

Ceftaroline: a novel broad-spectrum cephalosporin with activity against meticillin-resistant Staphylococcus aureus.

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0168-2

21 January 2018

Synthesis and SAR of novel parenteral anti-pseudomonal cephalosporins: discovery of FR264205.

1 reference

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21 January 2018

Structural requirements for the stability of novel cephalosporins to AmpC beta-lactamase based on 3D-structure

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21 January 2018

Three decades of beta-lactamase inhibitors

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Class A beta-lactamases--enzyme-inhibitor interactions and resistance

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21 January 2018

Designing new β-lactams: implications from their targets, resistance factors and synthesizing enzymes

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21 January 2018

The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0168-2

21 January 2018

Penicillin-binding proteins and beta-lactam resistance

1 reference

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21 January 2018

Affinity of the new cephalosporin CXA-101 to penicillin-binding proteins of Pseudomonas aeruginosa

1 reference

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21 January 2018

Beta-lactam resistance response triggered by inactivation of a nonessential penicillin-binding protein

1 reference

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21 January 2018

Kinetic interactions of tazobactam with beta-lactamases from all major structural classes

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21 January 2018

Activity of a new cephalosporin, CXA-101 (FR264205), against beta-lactam-resistant Pseudomonas aeruginosa mutants selected in vitro and after antipseudomonal treatment of intensive care unit patients

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21 January 2018

Evolution and adaptation in Pseudomonas aeruginosa biofilms driven by mismatch repair system-deficient mutators.

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21 January 2018

Antimicrobial activity of ceftolozane-tazobactam tested against Enterobacteriaceae and Pseudomonas aeruginosa with various resistance patterns isolated in U.S. Hospitals (2011-2012).

1 reference

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21 January 2018

In vitro activity of CXA-101 plus tazobactam (CXA-201) against CTX-M-14- and CTX-M-15-producing Escherichia coli and Klebsiella pneumoniae

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21 January 2018

In vivo activities of ceftolozane, a new cephalosporin, with and without tazobactam against Pseudomonas aeruginosa and Enterobacteriaceae, including strains with extended-spectrum β-lactamases, in the thighs of neutropenic mice.

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21 January 2018

Chequerboard titration of cephalosporin CXA-101 (FR264205) and tazobactam versus beta-lactamase-producing Enterobacteriaceae

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21 January 2018

Pharmacokinetics and safety of CXA-101, a new antipseudomonal cephalosporin, in healthy adult male and female subjects receiving single- and multiple-dose intravenous infusions

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21 January 2018

Pharmacokinetics and safety of intravenous ceftolozane-tazobactam in healthy adult subjects following single and multiple ascending doses

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Pharmacokinetics and tissue penetration of tazobactam administered alone and with piperacillin

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Intrapulmonary penetration of ceftolozane/tazobactam and piperacillin/tazobactam in healthy adult subjects

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21 January 2018

In vivo comparison of CXA-101 (FR264205) with and without tazobactam versus piperacillin-tazobactam using human simulated exposures against phenotypically diverse gram-negative organisms

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21 January 2018

Pharmacokinetics-pharmacodynamics of tazobactam in combination with ceftolozane in an in vitro infection model

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21 January 2018

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21 January 2018

Stability of FR264205 against AmpC beta-lactamase of Pseudomonas aeruginosa

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12 December 2020

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