Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms (Q34390412)

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14 February 2020

title

Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms (English)

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14 February 2020

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3

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14 February 2020

Arthur Berg

5

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14 February 2020

author name string

Gang Chen

1

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14 February 2020

Nino E Giambrone

2

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14 February 2020

Joshua E Muscat

4

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14 February 2020

Carla J Gallagher

6

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14 February 2020

Philip Lazarus

7

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14 February 2020

language of work or name

English

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publication date

28 September 2010

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14 February 2020

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14 February 2020

volume

70

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14 February 2020

issue

19

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14 February 2020

page(s)

7543-7552

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Nicotine metabolism in African Americans and European Americans: variation in glucuronidation by ethnicity and UGT2B10 haplotype

14 February 2020

cites work

1 reference

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Association of nicotine metabolite ratio and CYP2A6 genotype with smoking cessation treatment in African-American light smokers

6 July 2018

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Nicotine chemistry, metabolism, kinetics and biomarkers

6 July 2018

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Nicotine dependence pharmacogenetics: role of genetic variation in nicotine-metabolizing enzymes

6 July 2018

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Nicotine metabolic rate predicts successful smoking cessation with transdermal nicotine: a validation study

6 July 2018

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6 July 2018

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Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines

6 July 2018

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A novel CYP2A6 allele, CYP2A6*23, impairs enzyme function in vitro and in vivo and decreases smoking in a population of Black-African descent

6 July 2018

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Glucuronidation of nicotine and cotinine by UGT2B10: loss of function by the UGT2B10 Codon 67 (Asp>Tyr) polymorphism

6 July 2018

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Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10.

6 July 2018

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The UDP-glucuronosyltransferase 2B17 gene deletion polymorphism: sex-specific association with urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronidation phenotype and risk for lung cancer

6 July 2018

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Genotype-phenotype correlation between the polymorphic UGT2B17 gene deletion and NNAL glucuronidation activities in human liver microsomes

6 July 2018

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Interindividual variability in nicotine metabolism: C-oxidation and glucuronidation

6 July 2018

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Implications of CYP2A6 genetic variation for smoking behaviors and nicotine dependence.

6 July 2018

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Metabolism and disposition kinetics of nicotine

6 July 2018

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N-glucuronidation of nicotine and cotinine by human liver microsomes and heterologously expressed UDP-glucuronosyltransferases

6 July 2018

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A human minor histocompatibility antigen resulting from differential expression due to a gene deletion

6 July 2018

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Determination of nicotine N-1-glucuronide, a quaternary N-glucuronide conjugate, in human biological samples

6 July 2018

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Effects of watercress consumption on urinary metabolites of nicotine in smokers

6 July 2018

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Quantitation of 4-oxo-4-(3-pyridyl)butanoic acid and enantiomers of 4-hydroxy-4-(3-pyridyl)butanoic acid in human urine: A substantial pathway of nicotine metabolism

6 July 2018

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Nicotine metabolic profile in man: comparison of cigarette smoking and transdermal nicotine

6 July 2018

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Characterization of the glucuronide conjugate of cotinine: a previously unidentified major metabolite of nicotine in smokers' urine

6 July 2018

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Toward personalized therapy for smoking cessation: a randomized placebo-controlled trial of bupropion.

6 July 2018

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Tissue-specific mRNA expression profiles of human phase I metabolizing enzymes except for cytochrome P450 and phase II metabolizing enzymes.

27 October 2018

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Trans-3'-hydroxycotinine O- and N-glucuronidations in human liver microsomes.

27 October 2018

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Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity

27 October 2018

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27 October 2018

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Formation of the quaternary ammonium-linked glucuronide of nicotine in human liver microsomes: identification and stereoselectivity in the kinetics

27 October 2018

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27 October 2018

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Characterization of a common deletion polymorphism of the UGT2B17 gene linked to UGT2B15

27 October 2018

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12 December 2020

Nicotine and cotinine elimination pharmacokinetics in smokers and nonsmokers

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12 December 2020

Direct determination of cotinine-N-glucuronide in urine using thermospray liquid chromatography/mass spectrometry

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12 December 2020

Nicotine metabolite ratio predicts efficacy of transdermal nicotine for smoking cessation

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12 December 2020

10.1158/0008-5472.CAN-09-4582

Identifiers

DOI

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14 February 2020

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14 February 2020

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