Lessons from a BACE1 inhibitor trial: off-site but not off base. (Q34381433)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24530026%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

title

Lessons from a BACE1 inhibitor trial: off-site but not off base (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24530026%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

0 references

0 references

0 references

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2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24530026%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Justin M Long

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24530026%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

author name string

Debomoy K Lahiri

series ordinal

1

1 reference

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8 March 2020

Nigel H Greig

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24530026%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

language of work or name

English

0 references

publication date

12 February 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24530026%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

published in

Alzheimer's and Dementia

1 reference

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8 March 2020

volume

10

1 reference

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8 March 2020

issue

5 Suppl

1 reference

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8 March 2020

page(s)

S411-9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24530026%20AND%20SRC:MED&resulttype=core&format=json

MicroRNA-339-5p down-regulates protein expression of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) in human primary brain cultures and is reduced in brain tissue specimens of Alzheimer disease subjects

8 March 2020

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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MicroRNA-101 downregulates Alzheimer's amyloid-β precursor protein levels in human cell cultures and is differentially expressed.

6 July 2018

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Why so few drugs for Alzheimer's disease? Are methods failing drugs?

6 July 2018

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Suppressive and pro-inflammatory roles for IL-4 in the pathogenesis of experimental drug-induced liver injury: a review

6 July 2018

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The amyloid hypothesis for Alzheimer's disease: a critical reappraisal

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing

6 July 2018

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Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and environmental link for AD.

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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BACE1 gene promoter is differentially regulated: detection of a novel promoter region for its cell type-specific regulation

6 July 2018

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Control of APP processing and Abeta generation level by BACE1 enzymatic activity and transcription

6 July 2018

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Intracellular signaling mechanisms of acetaminophen-induced liver cell death

6 July 2018

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6 July 2018

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Functional characterization of the 5' flanking region of the BACE gene: identification of a 91 bp fragment involved in basal level of BACE promoter expression

6 July 2018

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Gene structure and organization of the human beta-secretase (BACE) promoter.

6 July 2018

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The metabolism and toxicity of quinones, quinonimines, quinone methides, and quinone-thioethers

6 July 2018

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Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

6 July 2018

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Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

6 July 2018

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A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase

6 July 2018

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6 July 2018

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

6 July 2018

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6 July 2018

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Dual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling.

27 October 2018

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27 October 2018

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27 October 2018

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27 October 2018

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27 October 2018

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Bace1 modulates myelination in the central and peripheral nervous system.

27 October 2018

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In vivo cleavage of alpha2,6-sialyltransferase by Alzheimer beta-secretase

27 October 2018

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27 October 2018

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BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes

27 October 2018

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Decreased melatonin levels in postmortem cerebrospinal fluid in relation to aging, Alzheimer's disease, and apolipoprotein E-epsilon4/4 genotype.

27 October 2018

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2013 Alzheimer's disease facts and figures

27 October 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/24530026

inferred from PubMed ID database lookup

12 December 2020

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Prions: a piece of the puzzle?

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12 December 2020

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Toxicophores: investigations in drug safety

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Identifiers

DOI

10.1016/J.JALZ.2013.11.004

1 reference

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8 March 2020

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